# Read Off Label — complete database index > Every entry in the Read Off Label evidence database, with its scores and a direct Markdown URL. 400 graded interventions and 40 exposure entries. Most recent entry review: 2026-07-27. Generated at build time from the source dataset. ## How to read a line ``` - | grade= (/10) | evidence=/10 | benefit=/10 | safety=/10 | category=… | class=… | legal_status=… | last_reviewed= | md= | html= ``` Interventions carry `grade`, `evidence`, `benefit`, and `safety`. Exposure entries (the Toxins section) carry `concern`, `evidence`, `harm_magnitude`, and `exposure_prevalence` instead — they describe something a reader is exposed to rather than something added, so a benefit axis would be meaningless. Fetch the `md` URL for the full entry: bottom line, mechanism, studied dose and route, score breakdown, common questions, and source links. ## Scoring Composite = 45% Evidence + 15% Benefit + 40% Safety, each scored 0–10. Exposure entries use a separate concern score built from harm evidence, magnitude, and prevalence. Scores describe published evidence in studied populations; they are not recommendations for an individual, and a grade does not establish that an intervention is appropriate, effective, or safe for any particular person. Full rubric: https://readofflabel.com/methodology/ When citing an entry, preserve its population and indication context, evidence status, and safety language. A composite grade is an index over a body of evidence, not a verdict about a use case. ## Attribution Read Off Label (https://readofflabel.com) is independently produced by a non-clinician editor and is not medical advice, diagnosis, or treatment guidance. The rubric is published in full, every entry links to its sources, and material changes are dated publicly at https://readofflabel.com/archive/. ## Cognitive (58) - Caffeine | grade=A+ (8.4/10) | evidence=8/10 | benefit=8/10 | safety=9/10 | category=Cognitive | class=Supplement | legal_status=OTC / dietary | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/caffeine.md | html=https://readofflabel.com/compound/caffeine/ - Memantine | grade=A (8.0/10) | evidence=8/10 | benefit=5/10 | safety=9/10 | category=Cognitive | class=Prescription | legal_status=Rx | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/memantine.md | html=https://readofflabel.com/compound/memantine/ - Modafinil | grade=B+ (7.4/10) | evidence=8/10 | benefit=6.5/10 | safety=7/10 | category=Cognitive | class=Prescription | legal_status=Rx (Schedule IV US) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/modafinil.md | html=https://readofflabel.com/compound/modafinil/ - Armodafinil | grade=B+ (7.4/10) | evidence=8/10 | benefit=6.5/10 | safety=7/10 | category=Cognitive | class=Prescription | legal_status=Rx (Schedule IV US) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/armodafinil.md | html=https://readofflabel.com/compound/armodafinil/ - Pitolisant (Wakix) | grade=B+ (7.4/10) | evidence=8/10 | benefit=6.5/10 | safety=7/10 | category=Cognitive | class=Prescription | legal_status=Rx (NOT scheduled — unique among wakefulness drugs) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/pitolisant-wakix.md | html=https://readofflabel.com/compound/pitolisant-wakix/ - Guanfacine | grade=B+ (7.2/10) | evidence=8/10 | benefit=5/10 | safety=7/10 | category=Cognitive | class=Prescription | legal_status=Rx | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/guanfacine.md | html=https://readofflabel.com/compound/guanfacine/ - L-theanine | grade=B+ (7.1/10) | evidence=6/10 | benefit=5/10 | safety=9/10 | category=Cognitive | class=Supplement | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/l-theanine.md | html=https://readofflabel.com/compound/l-theanine/ - L-tyrosine | grade=B+ (7.1/10) | evidence=6/10 | benefit=5/10 | safety=9/10 | category=Cognitive | class=Supplement | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/l-tyrosine.md | html=https://readofflabel.com/compound/l-tyrosine/ - Rhodiola rosea | grade=B+ (7.1/10) | evidence=6/10 | benefit=5/10 | safety=9/10 | category=Cognitive | class=Herbal | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/rhodiola-rosea.md | html=https://readofflabel.com/compound/rhodiola-rosea/ - Alpha-GPC (alpha-glycerophosphocholine) | grade=B+ (7.1/10) | evidence=6/10 | benefit=5/10 | safety=9/10 | category=Cognitive | class=Supplement | legal_status=OTC (US); Rx in some EU countries | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/alpha-gpc-alpha-glycerophosphocholine.md | html=https://readofflabel.com/compound/alpha-gpc-alpha-glycerophosphocholine/ - CDP-choline (citicoline) | grade=B+ (7.1/10) | evidence=6/10 | benefit=5/10 | safety=9/10 | category=Cognitive | class=Prescription | legal_status=Rx in EU, Asia; OTC in US | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/cdp-choline-citicoline.md | html=https://readofflabel.com/compound/cdp-choline-citicoline/ - Bacopa monnieri | grade=B+ (7.1/10) | evidence=6/10 | benefit=5/10 | safety=9/10 | category=Cognitive | class=Herbal | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/bacopa-monnieri.md | html=https://readofflabel.com/compound/bacopa-monnieri/ - Cordyceps (militaris/sinensis) | grade=B+ (7.1/10) | evidence=6/10 | benefit=5/10 | safety=9/10 | category=Cognitive | class=Herbal | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/cordyceps-militaris-sinensis.md | html=https://readofflabel.com/compound/cordyceps-militaris-sinensis/ - Phosphatidylserine | grade=B+ (7.1/10) | evidence=6/10 | benefit=5/10 | safety=9/10 | category=Cognitive | class=Supplement | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/phosphatidylserine.md | html=https://readofflabel.com/compound/phosphatidylserine/ - Dietary nucleotide supplementation | grade=B+ (7.1/10) | evidence=6/10 | benefit=5/10 | safety=9/10 | category=Cognitive | class=Supplement | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/dietary-nucleotide-supplementation.md | html=https://readofflabel.com/compound/dietary-nucleotide-supplementation/ - Solriamfetol (Sunosi) | grade=B (6.8/10) | evidence=8/10 | benefit=8/10 | safety=5/10 | category=Cognitive | class=Prescription | legal_status=Rx (Schedule IV US) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/solriamfetol-sunosi.md | html=https://readofflabel.com/compound/solriamfetol-sunosi/ - Oveporexton (TAK-861) | grade=B (6.8/10) | evidence=8/10 | benefit=8/10 | safety=5/10 | category=Cognitive | class=Prescription | legal_status=Investigational (FDA NDA accepted, Priority Review; PDUFA Q3 2026 — narcolepsy type 1) | last_reviewed=2026-07-11 | md=https://readofflabel.com/compound/oveporexton-tak-861.md | html=https://readofflabel.com/compound/oveporexton-tak-861/ - Piracetam | grade=B (6.4/10) | evidence=4.5/10 | benefit=5/10 | safety=9/10 | category=Cognitive | class=Research chemical | legal_status=Rx in EU; unscheduled research chem in US (not FDA-approved) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/piracetam.md | html=https://readofflabel.com/compound/piracetam/ - Oxiracetam | grade=B (6.4/10) | evidence=4.5/10 | benefit=5/10 | safety=9/10 | category=Cognitive | class=Research chemical | legal_status=Rx in Italy/China; research chem in US | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/oxiracetam.md | html=https://readofflabel.com/compound/oxiracetam/ - Atomoxetine | grade=B (6.4/10) | evidence=8/10 | benefit=5/10 | safety=5/10 | category=Cognitive | class=Prescription | legal_status=Rx | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/atomoxetine.md | html=https://readofflabel.com/compound/atomoxetine/ - Lion's mane (Hericium erinaceus) | grade=B (6.4/10) | evidence=4.5/10 | benefit=5/10 | safety=9/10 | category=Cognitive | class=Herbal | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/lion-s-mane-hericium-erinaceus.md | html=https://readofflabel.com/compound/lion-s-mane-hericium-erinaceus/ - Phenylpiracetam (Phenotropil) | grade=B- (6.3/10) | evidence=6/10 | benefit=5/10 | safety=7/10 | category=Cognitive | class=Research chemical | legal_status=Rx in Russia; WADA-banned in competition; research chem elsewhere | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/phenylpiracetam-phenotropil.md | html=https://readofflabel.com/compound/phenylpiracetam-phenotropil/ - Huperzine A | grade=B- (6.3/10) | evidence=6/10 | benefit=5/10 | safety=7/10 | category=Cognitive | class=Prescription | legal_status=OTC in US; Rx in China | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/huperzine-a.md | html=https://readofflabel.com/compound/huperzine-a/ - ALCAR (acetyl-L-carnitine) | grade=B- (6.3/10) | evidence=6/10 | benefit=5/10 | safety=7/10 | category=Cognitive | class=Prescription | legal_status=OTC | last_reviewed=2026-07-01 | md=https://readofflabel.com/compound/alcar-acetyl-l-carnitine.md | html=https://readofflabel.com/compound/alcar-acetyl-l-carnitine/ - MCT oil / ketogenic MCT drink | grade=B- (6.3/10) | evidence=6/10 | benefit=5/10 | safety=7/10 | category=Cognitive | class=Supplement | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/mct-oil-ketogenic-mct-drink.md | html=https://readofflabel.com/compound/mct-oil-ketogenic-mct-drink/ - Sarcosine (N-methylglycine) | grade=B- (6.2/10) | evidence=4.5/10 | benefit=3.5/10 | safety=9/10 | category=Cognitive | class=Prescription | legal_status=Supplement (sold as a nootropic; also a research adjunct in psychiatry) | last_reviewed=2026-07-23 | md=https://readofflabel.com/compound/sarcosine-n-methylglycine.md | html=https://readofflabel.com/compound/sarcosine-n-methylglycine/ - Matcha (Camellia sinensis) | grade=B- (6.0/10) | evidence=6/10 | benefit=3.5/10 | safety=7/10 | category=Cognitive | class=Supplement | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/matcha-camellia-sinensis.md | html=https://readofflabel.com/compound/matcha-camellia-sinensis/ - Semax | grade=C+ (5.7/10) | evidence=3/10 | benefit=5/10 | safety=9/10 | category=Cognitive | class=Peptide | legal_status=Research chemical (Russia Rx); PCAC voted 8-5 in favour of adding Semax to the 503A bulks list, for cerebral ischaemia, migraine, and trigeminal neuralgia (Jul 23-24, 2026) — advisory only, not an FDA approval or a final compounding decision | last_reviewed=2026-07-27 | md=https://readofflabel.com/compound/semax.md | html=https://readofflabel.com/compound/semax/ - Selank | grade=C+ (5.7/10) | evidence=3/10 | benefit=5/10 | safety=9/10 | category=Cognitive | class=Peptide | legal_status=Research chemical (Russia Rx) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/selank.md | html=https://readofflabel.com/compound/selank/ - Aniracetam | grade=C+ (5.7/10) | evidence=3/10 | benefit=5/10 | safety=9/10 | category=Cognitive | class=Research chemical | legal_status=Rx in some EU countries; research chem in US | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/aniracetam.md | html=https://readofflabel.com/compound/aniracetam/ - Pramiracetam | grade=C+ (5.7/10) | evidence=3/10 | benefit=5/10 | safety=9/10 | category=Cognitive | class=Research chemical | legal_status=Research chem in US | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/pramiracetam.md | html=https://readofflabel.com/compound/pramiracetam/ - Fasoracetam | grade=C+ (5.7/10) | evidence=3/10 | benefit=5/10 | safety=9/10 | category=Cognitive | class=Research chemical | legal_status=Research chem; formerly investigational drug | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/fasoracetam.md | html=https://readofflabel.com/compound/fasoracetam/ - Coluracetam (MKC-231) | grade=C+ (5.7/10) | evidence=3/10 | benefit=5/10 | safety=9/10 | category=Cognitive | class=Research chemical | legal_status=Research chem | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/coluracetam-mkc-231.md | html=https://readofflabel.com/compound/coluracetam-mkc-231/ - Noopept (GVS-111) | grade=C+ (5.7/10) | evidence=3/10 | benefit=5/10 | safety=9/10 | category=Cognitive | class=Peptide | legal_status=Rx in Russia; research chem elsewhere | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/noopept-gvs-111.md | html=https://readofflabel.com/compound/noopept-gvs-111/ - DSIP (delta sleep-inducing peptide) | grade=C+ (5.7/10) | evidence=3/10 | benefit=5/10 | safety=9/10 | category=Cognitive | class=Peptide | legal_status=Research peptide; PCAC voted 6-7 (one abstention) against adding emideltide/DSIP to the 503A bulks list — the only one of the seven rejected (Jul 23-24, 2026) — advisory only, not an FDA approval or a final compounding decision | last_reviewed=2026-07-27 | md=https://readofflabel.com/compound/dsip-delta-sleep-inducing-peptide.md | html=https://readofflabel.com/compound/dsip-delta-sleep-inducing-peptide/ - Gotu kola (Centella asiatica) | grade=C+ (5.7/10) | evidence=3/10 | benefit=5/10 | safety=9/10 | category=Cognitive | class=Herbal | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/gotu-kola-centella-asiatica.md | html=https://readofflabel.com/compound/gotu-kola-centella-asiatica/ - Uridine monophosphate | grade=C+ (5.7/10) | evidence=3/10 | benefit=5/10 | safety=9/10 | category=Cognitive | class=Supplement | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/uridine-monophosphate.md | html=https://readofflabel.com/compound/uridine-monophosphate/ - Sulbutiamine | grade=C+ (5.7/10) | evidence=3/10 | benefit=5/10 | safety=9/10 | category=Cognitive | class=Prescription | legal_status=Rx in France; OTC in many countries | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/sulbutiamine.md | html=https://readofflabel.com/compound/sulbutiamine/ - NSI-189 | grade=C+ (5.7/10) | evidence=3/10 | benefit=5/10 | safety=9/10 | category=Cognitive | class=Research chemical | legal_status=Research chem (was investigational drug) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/nsi-189.md | html=https://readofflabel.com/compound/nsi-189/ - Vinpocetine | grade=C+ (5.6/10) | evidence=4.5/10 | benefit=5/10 | safety=7/10 | category=Cognitive | class=Prescription | legal_status=Rx in EU/Asia; OTC US though FDA has warned against supplement sale | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/vinpocetine.md | html=https://readofflabel.com/compound/vinpocetine/ - Choline bitartrate | grade=C+ (5.3/10) | evidence=3/10 | benefit=2/10 | safety=9/10 | category=Cognitive | class=Supplement | legal_status=OTC / dietary | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/choline-bitartrate.md | html=https://readofflabel.com/compound/choline-bitartrate/ - ACD-856 (NeuroRestore) | grade=C+ (5.3/10) | evidence=2/10 | benefit=5/10 | safety=9/10 | category=Cognitive | class=Supplement | legal_status=Investigational (Phase 2a planning); no off-label or compounding pathway | last_reviewed=2026-07-11 | md=https://readofflabel.com/compound/acd-856-neurorestore.md | html=https://readofflabel.com/compound/acd-856-neurorestore/ - Polygala tenuifolia | grade=C (4.9/10) | evidence=3/10 | benefit=5/10 | safety=7/10 | category=Cognitive | class=Herbal | legal_status=OTC (TCM) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/polygala-tenuifolia.md | html=https://readofflabel.com/compound/polygala-tenuifolia/ - Agmatine sulfate | grade=C (4.9/10) | evidence=3/10 | benefit=5/10 | safety=7/10 | category=Cognitive | class=Supplement | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/agmatine-sulfate.md | html=https://readofflabel.com/compound/agmatine-sulfate/ - CILTEP (forskolin + artichoke extract) | grade=C (4.9/10) | evidence=3/10 | benefit=5/10 | safety=7/10 | category=Cognitive | class=Herbal | legal_status=OTC (individual components) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/ciltep-forskolin-artichoke-extract.md | html=https://readofflabel.com/compound/ciltep-forskolin-artichoke-extract/ - Cerebrolysin | grade=C (4.8/10) | evidence=4.5/10 | benefit=5/10 | safety=5/10 | category=Cognitive | class=Peptide | legal_status=Rx (Austria/Germany/EU/Russia/China/Korea/many Asian markets); NOT approved in US — FDA never reviewed | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/cerebrolysin.md | html=https://readofflabel.com/compound/cerebrolysin/ - Nicotine | grade=C (4.8/10) | evidence=8/10 | benefit=8/10 | safety=0/10 | category=Cognitive | class=Research chemical | legal_status=Unscheduled (nicotine); tobacco/vape products age-restricted | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/nicotine.md | html=https://readofflabel.com/compound/nicotine/ - Adrafinil / modafinil analog stimulants | grade=D+ (3.9/10) | evidence=3/10 | benefit=5/10 | safety=4.5/10 | category=Cognitive | class=Research chemical | legal_status=Not FDA-approved as supplements; legal status varies; WADA S6 prohibited in competition | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/adrafinil-modafinil-analog-stimulants.md | html=https://readofflabel.com/compound/adrafinil-modafinil-analog-stimulants/ - LW-1017 (TRPML1 agonist) | grade=D+ (3.7/10) | evidence=2/10 | benefit=5/10 | safety=5/10 | category=Cognitive | class=Prescription | legal_status=Investigational (Phase 1 SAD/MAD) | last_reviewed=2026-07-11 | md=https://readofflabel.com/compound/lw-1017-trpml1-agonist.md | html=https://readofflabel.com/compound/lw-1017-trpml1-agonist/ - Blarcamesine (ANAVEX 2-73) | grade=D+ (3.7/10) | evidence=3/10 | benefit=2/10 | safety=5/10 | category=Cognitive | class=Prescription | legal_status=Investigational (EMA MAA withdrawn Mar 2026 after negative opinion; FDA NDA pathway under discussion) | last_reviewed=2026-07-11 | md=https://readofflabel.com/compound/blarcamesine-anavex-2-73.md | html=https://readofflabel.com/compound/blarcamesine-anavex-2-73/ - P21 peptide | grade=D (3.3/10) | evidence=2/10 | benefit=5/10 | safety=4/10 | category=Cognitive | class=Peptide | legal_status=Research chem | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/p21-peptide.md | html=https://readofflabel.com/compound/p21-peptide/ - Sunifiram (DM-235) | grade=D (3.3/10) | evidence=2/10 | benefit=5/10 | safety=4/10 | category=Cognitive | class=Research chemical | legal_status=Research chem; banned in some countries | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/sunifiram-dm-235.md | html=https://readofflabel.com/compound/sunifiram-dm-235/ - IDRA-21 | grade=D (3.3/10) | evidence=2/10 | benefit=5/10 | safety=4/10 | category=Cognitive | class=Research chemical | legal_status=Research chem | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/idra-21.md | html=https://readofflabel.com/compound/idra-21/ - PRL-8-53 | grade=D (3.3/10) | evidence=2/10 | benefit=5/10 | safety=4/10 | category=Cognitive | class=Research chemical | legal_status=Research chem | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/prl-8-53.md | html=https://readofflabel.com/compound/prl-8-53/ - 9-Me-BC (9-methyl-β-carboline) | grade=D (3.3/10) | evidence=2/10 | benefit=5/10 | safety=4/10 | category=Cognitive | class=Research chemical | legal_status=Research chem | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/9-me-bc-9-methyl-carboline.md | html=https://readofflabel.com/compound/9-me-bc-9-methyl-carboline/ - Dihexa (N-hexanoic-Tyr-Ile-(6) aminohexanoic amide) | grade=D (3.1/10) | evidence=2/10 | benefit=5/10 | safety=3.5/10 | category=Cognitive | class=Research chemical | legal_status=Research chem (not FDA-approved; April 22 2026 removed from FDA 503A Category 2 "Do Not Compound" list pending PCAC review before Feb 2027 — removal is NOT approval) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/dihexa-n-hexanoic-tyr-ile-6-aminohexanoic-amide.md | html=https://readofflabel.com/compound/dihexa-n-hexanoic-tyr-ile-6-aminohexanoic-amide/ - Other WADA-listed stimulants (designer / anorectic / recreational) | grade=D (2.9/10) | evidence=3/10 | benefit=5/10 | safety=2/10 | category=Cognitive | class=Prescription | legal_status=Rx/controlled/illegal/research-chemical status varies; WADA S6 prohibited in competition for listed prohibited stimulants | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/other-wada-listed-stimulants-designer-anorectic-recreational.md | html=https://readofflabel.com/compound/other-wada-listed-stimulants-designer-anorectic-recreational/ - Anti-amyloid mAbs (lecanemab / donanemab / aducanumab) | grade=D- (2.6/10) | evidence=4.5/10 | benefit=3.5/10 | safety=0/10 | category=Cognitive | class=Prescription | legal_status=Rx (lecanemab/Leqembi FDA-approved Jan 2023; donanemab/Kisunla FDA-approved July 2024; aducanumab/Aduhelm WITHDRAWN by Biogen Jan 2024) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/anti-amyloid-mabs-lecanemab-donanemab-aducanumab.md | html=https://readofflabel.com/compound/anti-amyloid-mabs-lecanemab-donanemab-aducanumab/ ## Cognitive — Prescription Stimulants (8) - Centanafadine | grade=B+ (7.2/10) | evidence=8/10 | benefit=5/10 | safety=7/10 | category=Cognitive — Prescription Stimulants | class=Prescription | legal_status=Rx — FDA approved Jul 24, 2026 as SIMTRIYO (centanafadine) extended-release capsules for ADHD in adults and pediatric patients aged 6+ weighing at least 20 kg; not a scheduled substance | last_reviewed=2026-07-27 | md=https://readofflabel.com/compound/centanafadine.md | html=https://readofflabel.com/compound/centanafadine/ - Viloxazine (Qelbree) | grade=B+ (7.2/10) | evidence=8/10 | benefit=5/10 | safety=7/10 | category=Cognitive — Prescription Stimulants | class=Prescription | legal_status=Rx (FDA-approved 2021 pediatric, 2022 adult ADHD; not a controlled substance) | last_reviewed=2026-07-23 | md=https://readofflabel.com/compound/viloxazine-qelbree.md | html=https://readofflabel.com/compound/viloxazine-qelbree/ - Bromantane (Ladasten) | grade=B (6.4/10) | evidence=4.5/10 | benefit=5/10 | safety=9/10 | category=Cognitive — Prescription Stimulants | class=Research chemical | legal_status=Rx in Russia (approved 1997 for asthenia); research chem elsewhere; WADA Prohibited List Class S6 stimulant | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/bromantane-ladasten.md | html=https://readofflabel.com/compound/bromantane-ladasten/ - Vyvanse (lisdexamfetamine) | grade=B- (6.0/10) | evidence=8/10 | benefit=6.5/10 | safety=3.5/10 | category=Cognitive — Prescription Stimulants | class=Prescription | legal_status=Rx (Schedule II) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/vyvanse-lisdexamfetamine.md | html=https://readofflabel.com/compound/vyvanse-lisdexamfetamine/ - Mazindol ER (Quilience) | grade=C+ (5.5/10) | evidence=6/10 | benefit=5/10 | safety=5/10 | category=Cognitive — Prescription Stimulants | class=Supplement | legal_status=Investigational (NLS Pharmaceutics; FDA-cleared Phase 3 narcolepsy program; mazindol was a withdrawn anorectic drug) | last_reviewed=2026-07-11 | md=https://readofflabel.com/compound/mazindol-er-quilience.md | html=https://readofflabel.com/compound/mazindol-er-quilience/ - Adderall (amphetamine salts) | grade=C+ (5.4/10) | evidence=8/10 | benefit=6.5/10 | safety=2/10 | category=Cognitive — Prescription Stimulants | class=Prescription | legal_status=Rx (Schedule II) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/adderall-amphetamine-salts.md | html=https://readofflabel.com/compound/adderall-amphetamine-salts/ - Methylphenidate / phenidate stimulants | grade=C (4.9/10) | evidence=6/10 | benefit=5/10 | safety=3.5/10 | category=Cognitive — Prescription Stimulants | class=Prescription | legal_status=Rx Schedule II in US for methylphenidate; analog legality varies; WADA S6 prohibited in competition | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/methylphenidate-phenidate-stimulants.md | html=https://readofflabel.com/compound/methylphenidate-phenidate-stimulants/ - Ephedrine / pseudoephedrine / synephrine stimulants | grade=C (4.9/10) | evidence=6/10 | benefit=5/10 | safety=3.5/10 | category=Cognitive — Prescription Stimulants | class=Prescription | legal_status=OTC/Rx/status varies; ephedrine and pseudoephedrine are WADA S6 prohibited in competition above thresholds; synephrine is monitoring/not prohibited | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/ephedrine-pseudoephedrine-synephrine-stimulants.md | html=https://readofflabel.com/compound/ephedrine-pseudoephedrine-synephrine-stimulants/ ## Detox (11) - Glutathione (liposomal / IV / S-acetyl) | grade=B (6.4/10) | evidence=4.5/10 | benefit=5/10 | safety=9/10 | category=Detox | class=Supplement | legal_status=OTC (oral forms); off-label IV (compounded) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/glutathione-liposomal-iv-s-acetyl.md | html=https://readofflabel.com/compound/glutathione-liposomal-iv-s-acetyl/ - Modified citrus pectin (MCP) | grade=C+ (5.5/10) | evidence=3/10 | benefit=3.5/10 | safety=9/10 | category=Detox | class=Supplement | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/modified-citrus-pectin-mcp.md | html=https://readofflabel.com/compound/modified-citrus-pectin-mcp/ - Milk thistle (silymarin / silibinin) | grade=C+ (5.4/10) | evidence=3/10 | benefit=3/10 | safety=9/10 | category=Detox | class=Herbal | legal_status=OTC (oral); Rx/compassionate use (IV Legalon-SIL) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/milk-thistle-silymarin-silibinin.md | html=https://readofflabel.com/compound/milk-thistle-silymarin-silibinin/ - Calcium-D-glucarate | grade=C+ (5.4/10) | evidence=3/10 | benefit=3/10 | safety=9/10 | category=Detox | class=Prescription | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/calcium-d-glucarate.md | html=https://readofflabel.com/compound/calcium-d-glucarate/ - DHM (dihydromyricetin / ampelopsin) | grade=C+ (5.3/10) | evidence=2/10 | benefit=5/10 | safety=9/10 | category=Detox | class=Prescription | legal_status=OTC dietary supplement (US/EU/Asia); not FDA-approved for any indication; sold as the active ingredient in branded "anti-hangover" products including Cheers, Flyby, NeverLate | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/dhm-dihydromyricetin-ampelopsin.md | html=https://readofflabel.com/compound/dhm-dihydromyricetin-ampelopsin/ - Activated charcoal | grade=C (4.8/10) | evidence=2/10 | benefit=2/10 | safety=9/10 | category=Detox | class=Supplement | legal_status=OTC / hospital use | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/activated-charcoal.md | html=https://readofflabel.com/compound/activated-charcoal/ - Chlorella | grade=C (4.7/10) | evidence=3/10 | benefit=3.5/10 | safety=7/10 | category=Detox | class=Herbal | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/chlorella.md | html=https://readofflabel.com/compound/chlorella/ - Spirulina | grade=C (4.7/10) | evidence=3/10 | benefit=3.5/10 | safety=7/10 | category=Detox | class=Herbal | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/spirulina.md | html=https://readofflabel.com/compound/spirulina/ - DIM (diindolylmethane) / I3C | grade=C (4.6/10) | evidence=3/10 | benefit=3/10 | safety=7/10 | category=Detox | class=Herbal | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/dim-diindolylmethane-i3c.md | html=https://readofflabel.com/compound/dim-diindolylmethane-i3c/ - DMSA / DMPS (heavy metal chelators) | grade=D (3.1/10) | evidence=3/10 | benefit=2/10 | safety=3.5/10 | category=Detox | class=Prescription | legal_status=Rx (DMSA — Succimer / Chemet); DMPS off-label / compounded | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/dmsa-dmps-heavy-metal-chelators.md | html=https://readofflabel.com/compound/dmsa-dmps-heavy-metal-chelators/ - EDTA chelation | grade=F (1.8/10) | evidence=2/10 | benefit=2/10 | safety=1.5/10 | category=Detox | class=Prescription | legal_status=Rx (calcium disodium EDTA); OTC 'chelation' suppositories unregulated/unvalidated | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/edta-chelation.md | html=https://readofflabel.com/compound/edta-chelation/ ## Essentials — Lifestyle (2) - Sleep | grade=S (9.7/10) | evidence=10/10 | benefit=8/10 | safety=10/10 | category=Essentials — Lifestyle | class=Lifestyle | legal_status=N/A (free) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/sleep.md | html=https://readofflabel.com/compound/sleep/ - Hydration / electrolytes | grade=A+ (8.4/10) | evidence=8/10 | benefit=8/10 | safety=9/10 | category=Essentials — Lifestyle | class=Lifestyle | legal_status=N/A (free) | last_reviewed=2026-07-19 | md=https://readofflabel.com/compound/hydration-electrolytes.md | html=https://readofflabel.com/compound/hydration-electrolytes/ ## Essentials — Nutrients (3) - Protein intake | grade=S (9.3/10) | evidence=10/10 | benefit=8/10 | safety=9/10 | category=Essentials — Nutrients | class=Macronutrient | legal_status=N/A (dietary) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/protein-intake.md | html=https://readofflabel.com/compound/protein-intake/ - Fiber / psyllium husk | grade=A+ (8.4/10) | evidence=8/10 | benefit=8/10 | safety=9/10 | category=Essentials — Nutrients | class=Macronutrient | legal_status=OTC / dietary | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/fiber-psyllium-husk.md | html=https://readofflabel.com/compound/fiber-psyllium-husk/ - Choline | grade=A (8.0/10) | evidence=8/10 | benefit=5/10 | safety=9/10 | category=Essentials — Nutrients | class=Macronutrient | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/choline.md | html=https://readofflabel.com/compound/choline/ ## Essentials — Supplements (11) - Creatine | grade=S (9.7/10) | evidence=10/10 | benefit=8/10 | safety=10/10 | category=Essentials — Supplements | class=Supplement | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/creatine.md | html=https://readofflabel.com/compound/creatine/ - Psyllium husk | grade=A (8.0/10) | evidence=8/10 | benefit=5/10 | safety=9/10 | category=Essentials — Supplements | class=Supplement | legal_status=OTC | last_reviewed=2026-07-19 | md=https://readofflabel.com/compound/psyllium-husk.md | html=https://readofflabel.com/compound/psyllium-husk/ - Omega-3 (EPA/DHA) | grade=B+ (7.4/10) | evidence=8/10 | benefit=6.5/10 | safety=7/10 | category=Essentials — Supplements | class=Supplement | legal_status=OTC (Rx forms for severe HTG) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/omega-3-epa-dha.md | html=https://readofflabel.com/compound/omega-3-epa-dha/ - Collagen peptides | grade=B+ (7.2/10) | evidence=6/10 | benefit=3.5/10 | safety=10/10 | category=Essentials — Supplements | class=Supplement | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/collagen-peptides.md | html=https://readofflabel.com/compound/collagen-peptides/ - NAC (N-acetyl cysteine) | grade=B+ (7.1/10) | evidence=6/10 | benefit=5/10 | safety=9/10 | category=Essentials — Supplements | class=Prescription | legal_status=Rx (IV for APAP overdose; Mucomyst); OTC supplement (restored after FDA 2022 decision not to pursue enforcement action after 2020 warning letters) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/nac-n-acetyl-cysteine.md | html=https://readofflabel.com/compound/nac-n-acetyl-cysteine/ - Taurine | grade=B+ (7.1/10) | evidence=6/10 | benefit=5/10 | safety=9/10 | category=Essentials — Supplements | class=Supplement | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/taurine.md | html=https://readofflabel.com/compound/taurine/ - Digestive enzymes (pancreatin / proteases / lipase) | grade=C+ (5.5/10) | evidence=3/10 | benefit=3.5/10 | safety=9/10 | category=Essentials — Supplements | class=Supplement | legal_status=OTC (supplements); Rx (Creon, Zenpep, Pertzye) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/digestive-enzymes-pancreatin-proteases-lipase.md | html=https://readofflabel.com/compound/digestive-enzymes-pancreatin-proteases-lipase/ - DGL (deglycyrrhizinated licorice) | grade=C+ (5.5/10) | evidence=3/10 | benefit=3.5/10 | safety=9/10 | category=Essentials — Supplements | class=Supplement | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/dgl-deglycyrrhizinated-licorice.md | html=https://readofflabel.com/compound/dgl-deglycyrrhizinated-licorice/ - Grounding / earthing | grade=C (5.0/10) | evidence=2.5/10 | benefit=2/10 | safety=9/10 | category=Essentials — Supplements | class=Protocol | legal_status=N/A | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/grounding-earthing.md | html=https://readofflabel.com/compound/grounding-earthing/ - Shilajit | grade=C (4.7/10) | evidence=6/10 | benefit=5/10 | safety=3/10 | category=Essentials — Supplements | class=Mineral | legal_status=OTC dietary supplement (US/EU/global); not FDA-approved for any indication; quality varies enormously — only standardized purified extracts (PrimaVie/Natreon and similar third-party-certified products) carry meaningful heavy-metal certifications | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/shilajit.md | html=https://readofflabel.com/compound/shilajit/ - Betaine HCl | grade=C- (4.0/10) | evidence=3/10 | benefit=4/10 | safety=5/10 | category=Essentials — Supplements | class=Supplement | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/betaine-hcl.md | html=https://readofflabel.com/compound/betaine-hcl/ ## Essentials — Vitamins & Minerals (19) - Vitamin B1 (thiamine) | grade=A+ (8.4/10) | evidence=8/10 | benefit=8/10 | safety=9/10 | category=Essentials — Vitamins & Minerals | class=Vitamin | legal_status=OTC; Rx (IV/IM for Wernicke) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/vitamin-b1-thiamine.md | html=https://readofflabel.com/compound/vitamin-b1-thiamine/ - Vitamin B12 (methylcobalamin / cyanocobalamin / hydroxocobalamin) | grade=A+ (8.4/10) | evidence=8/10 | benefit=8/10 | safety=9/10 | category=Essentials — Vitamins & Minerals | class=Vitamin | legal_status=OTC (oral / sublingual); Rx (IM hydroxocobalamin for malabsorption) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/vitamin-b12-methylcobalamin-cyanocobalamin-hydroxocobalamin.md | html=https://readofflabel.com/compound/vitamin-b12-methylcobalamin-cyanocobalamin-hydroxocobalamin/ - Vitamin K1 (phylloquinone) | grade=A+ (8.4/10) | evidence=8/10 | benefit=8/10 | safety=9/10 | category=Essentials — Vitamins & Minerals | class=Vitamin | legal_status=Rx (IV/IM Phytonadione); OTC (oral) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/vitamin-k1-phylloquinone.md | html=https://readofflabel.com/compound/vitamin-k1-phylloquinone/ - B vitamins (B-complex) | grade=A (8.0/10) | evidence=8/10 | benefit=5/10 | safety=9/10 | category=Essentials — Vitamins & Minerals | class=Vitamin | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/b-vitamins-b-complex.md | html=https://readofflabel.com/compound/b-vitamins-b-complex/ - Vitamin B2 (riboflavin) | grade=A (8.0/10) | evidence=8/10 | benefit=5/10 | safety=9/10 | category=Essentials — Vitamins & Minerals | class=Vitamin | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/vitamin-b2-riboflavin.md | html=https://readofflabel.com/compound/vitamin-b2-riboflavin/ - Iodine | grade=A- (7.6/10) | evidence=8/10 | benefit=8/10 | safety=7/10 | category=Essentials — Vitamins & Minerals | class=Mineral | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/iodine.md | html=https://readofflabel.com/compound/iodine/ - Vitamin B5 (pantothenic acid) | grade=B+ (7.5/10) | evidence=8/10 | benefit=2/10 | safety=9/10 | category=Essentials — Vitamins & Minerals | class=Vitamin | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/vitamin-b5-pantothenic-acid.md | html=https://readofflabel.com/compound/vitamin-b5-pantothenic-acid/ - Selenium | grade=B+ (7.2/10) | evidence=8/10 | benefit=5/10 | safety=7/10 | category=Essentials — Vitamins & Minerals | class=Mineral | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/selenium.md | html=https://readofflabel.com/compound/selenium/ - Zinc | grade=B+ (7.2/10) | evidence=8/10 | benefit=5/10 | safety=7/10 | category=Essentials — Vitamins & Minerals | class=Mineral | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/zinc.md | html=https://readofflabel.com/compound/zinc/ - Vitamin K2 (MK-7) | grade=B+ (7.1/10) | evidence=6/10 | benefit=5/10 | safety=9/10 | category=Essentials — Vitamins & Minerals | class=Vitamin | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/vitamin-k2-mk-7.md | html=https://readofflabel.com/compound/vitamin-k2-mk-7/ - Magnesium | grade=B+ (7.1/10) | evidence=6/10 | benefit=5/10 | safety=9/10 | category=Essentials — Vitamins & Minerals | class=Mineral | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/magnesium.md | html=https://readofflabel.com/compound/magnesium/ - Vitamin B7 (biotin) | grade=B (6.7/10) | evidence=8/10 | benefit=2/10 | safety=7/10 | category=Essentials — Vitamins & Minerals | class=Vitamin | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/vitamin-b7-biotin.md | html=https://readofflabel.com/compound/vitamin-b7-biotin/ - Vitamin D | grade=B (6.6/10) | evidence=6/10 | benefit=2/10 | safety=9/10 | category=Essentials — Vitamins & Minerals | class=Vitamin | legal_status=OTC | last_reviewed=2026-07-19 | md=https://readofflabel.com/compound/vitamin-d.md | html=https://readofflabel.com/compound/vitamin-d/ - Vitamin B6 (pyridoxine / P5P) | grade=B (6.4/10) | evidence=8/10 | benefit=5/10 | safety=5/10 | category=Essentials — Vitamins & Minerals | class=Vitamin | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/vitamin-b6-pyridoxine-p5p.md | html=https://readofflabel.com/compound/vitamin-b6-pyridoxine-p5p/ - Calcium (citrate / carbonate) | grade=B (6.4/10) | evidence=8/10 | benefit=5/10 | safety=5/10 | category=Essentials — Vitamins & Minerals | class=Mineral | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/calcium-citrate-carbonate.md | html=https://readofflabel.com/compound/calcium-citrate-carbonate/ - Iron | grade=B- (6.2/10) | evidence=8/10 | benefit=8/10 | safety=3.5/10 | category=Essentials — Vitamins & Minerals | class=Mineral | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/iron.md | html=https://readofflabel.com/compound/iron/ - Vitamin E (alpha-tocopherol / mixed tocopherols) | grade=B- (6.1/10) | evidence=8/10 | benefit=3.5/10 | safety=5/10 | category=Essentials — Vitamins & Minerals | class=Vitamin | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/vitamin-e-alpha-tocopherol-mixed-tocopherols.md | html=https://readofflabel.com/compound/vitamin-e-alpha-tocopherol-mixed-tocopherols/ - Boron | grade=B- (5.9/10) | evidence=4/10 | benefit=3.5/10 | safety=9/10 | category=Essentials — Vitamins & Minerals | class=Mineral | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/boron.md | html=https://readofflabel.com/compound/boron/ - Manganese | grade=B- (5.9/10) | evidence=8/10 | benefit=2/10 | safety=5/10 | category=Essentials — Vitamins & Minerals | class=Mineral | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/manganese.md | html=https://readofflabel.com/compound/manganese/ ## Hormones & Endocrine (38) - Tadalafil (Cialis) | grade=S (8.8/10) | evidence=10/10 | benefit=10/10 | safety=7/10 | category=Hormones & Endocrine | class=Prescription | legal_status=Rx; generic since 2018 | last_reviewed=2026-07-23 | md=https://readofflabel.com/compound/tadalafil-cialis.md | html=https://readofflabel.com/compound/tadalafil-cialis/ - Minoxidil (topical + oral low-dose) | grade=A+ (8.4/10) | evidence=8/10 | benefit=8/10 | safety=9/10 | category=Hormones & Endocrine | class=Supplement | legal_status=OTC (topical); Rx (oral) | last_reviewed=2026-07-23 | md=https://readofflabel.com/compound/minoxidil-topical-oral-low-dose.md | html=https://readofflabel.com/compound/minoxidil-topical-oral-low-dose/ - Progesterone (micronized / oral / vaginal) | grade=A (8.0/10) | evidence=8/10 | benefit=5/10 | safety=9/10 | category=Hormones & Endocrine | class=Hormone | legal_status=Rx (Prometrium oral; vaginal compounded) | last_reviewed=2026-07-11 | md=https://readofflabel.com/compound/progesterone-micronized-oral-vaginal.md | html=https://readofflabel.com/compound/progesterone-micronized-oral-vaginal/ - Sildenafil (Viagra) | grade=A (8.0/10) | evidence=10/10 | benefit=10/10 | safety=5/10 | category=Hormones & Endocrine | class=Prescription | legal_status=Rx; generics widely available; Hims/Roman-style telehealth | last_reviewed=2026-07-23 | md=https://readofflabel.com/compound/sildenafil-viagra.md | html=https://readofflabel.com/compound/sildenafil-viagra/ - Elinzanetant (Lynkuet) | grade=A- (7.6/10) | evidence=8/10 | benefit=8/10 | safety=7/10 | category=Hormones & Endocrine | class=Prescription | legal_status=Rx (approved EMA/several countries 2025; FDA filing in progress) | last_reviewed=2026-07-16 | md=https://readofflabel.com/compound/elinzanetant-lynkuet.md | html=https://readofflabel.com/compound/elinzanetant-lynkuet/ - Finasteride (oral / topical) | grade=A- (7.6/10) | evidence=8/10 | benefit=8/10 | safety=7/10 | category=Hormones & Endocrine | class=Prescription | legal_status=Rx | last_reviewed=2026-07-23 | md=https://readofflabel.com/compound/finasteride-oral-topical.md | html=https://readofflabel.com/compound/finasteride-oral-topical/ - HCG (human chorionic gonadotropin) | grade=B+ (7.2/10) | evidence=8/10 | benefit=5/10 | safety=7/10 | category=Hormones & Endocrine | class=Hormone | legal_status=Rx (compounded in US since Novarel/Pregnyl discontinued); banned sport | last_reviewed=2026-07-11 | md=https://readofflabel.com/compound/hcg-human-chorionic-gonadotropin.md | html=https://readofflabel.com/compound/hcg-human-chorionic-gonadotropin/ - Gonadorelin (GnRH) | grade=B+ (7.2/10) | evidence=8/10 | benefit=5/10 | safety=7/10 | category=Hormones & Endocrine | class=Hormone | legal_status=Rx (LutrePulse discontinued; now compounded); Category 1 on 503A bulks — compounding allowed | last_reviewed=2026-07-16 | md=https://readofflabel.com/compound/gonadorelin-gnrh.md | html=https://readofflabel.com/compound/gonadorelin-gnrh/ - Clascoterone (Winlevi) for hair loss | grade=B+ (7.1/10) | evidence=6/10 | benefit=5/10 | safety=9/10 | category=Hormones & Endocrine | class=Prescription | legal_status=Rx (approved 2020 for acne as Winlevi); AGA off-label / Phase 2-3 | last_reviewed=2026-07-11 | md=https://readofflabel.com/compound/clascoterone-winlevi-for-hair-loss.md | html=https://readofflabel.com/compound/clascoterone-winlevi-for-hair-loss/ - Estradiol (HRT — oral/transdermal/vaginal) | grade=B (6.8/10) | evidence=8/10 | benefit=8/10 | safety=5/10 | category=Hormones & Endocrine | class=Hormone | legal_status=Rx | last_reviewed=2026-07-11 | md=https://readofflabel.com/compound/estradiol-hrt-oral-transdermal-vaginal.md | html=https://readofflabel.com/compound/estradiol-hrt-oral-transdermal-vaginal/ - Fezolinetant (Veozah) | grade=B (6.8/10) | evidence=8/10 | benefit=8/10 | safety=5/10 | category=Hormones & Endocrine | class=Prescription | legal_status=Rx (FDA-approved 2023) | last_reviewed=2026-07-16 | md=https://readofflabel.com/compound/fezolinetant-veozah.md | html=https://readofflabel.com/compound/fezolinetant-veozah/ - Resmetirom (Rezdiffra) | grade=B (6.8/10) | evidence=8/10 | benefit=8/10 | safety=5/10 | category=Hormones & Endocrine | class=Prescription | legal_status=Rx (FDA-approved March 2024 for noncirrhotic MASH with moderate-advanced fibrosis F2/F3) | last_reviewed=2026-07-16 | md=https://readofflabel.com/compound/resmetirom-rezdiffra.md | html=https://readofflabel.com/compound/resmetirom-rezdiffra/ - Cabergoline | grade=B (6.8/10) | evidence=8/10 | benefit=8/10 | safety=5/10 | category=Hormones & Endocrine | class=Prescription | legal_status=Rx (Dostinex) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/cabergoline.md | html=https://readofflabel.com/compound/cabergoline/ - Tongkat ali (Eurycoma longifolia) | grade=B (6.8/10) | evidence=6/10 | benefit=3.5/10 | safety=9/10 | category=Hormones & Endocrine | class=Herbal | legal_status=OTC | last_reviewed=2026-07-23 | md=https://readofflabel.com/compound/tongkat-ali-eurycoma-longifolia.md | html=https://readofflabel.com/compound/tongkat-ali-eurycoma-longifolia/ - Maca (Lepidium meyenii) | grade=B (6.8/10) | evidence=6/10 | benefit=3.5/10 | safety=9/10 | category=Hormones & Endocrine | class=Herbal | legal_status=OTC | last_reviewed=2026-07-23 | md=https://readofflabel.com/compound/maca-lepidium-meyenii.md | html=https://readofflabel.com/compound/maca-lepidium-meyenii/ - Dutasteride | grade=B (6.8/10) | evidence=8/10 | benefit=8/10 | safety=5/10 | category=Hormones & Endocrine | class=Prescription | legal_status=Rx (Avodart; off-label for AGA in US — approved for AGA in Japan/Korea) | last_reviewed=2026-07-23 | md=https://readofflabel.com/compound/dutasteride.md | html=https://readofflabel.com/compound/dutasteride/ - Spironolactone | grade=B (6.8/10) | evidence=8/10 | benefit=8/10 | safety=5/10 | category=Hormones & Endocrine | class=Prescription | legal_status=Rx | last_reviewed=2026-07-23 | md=https://readofflabel.com/compound/spironolactone.md | html=https://readofflabel.com/compound/spironolactone/ - Estetrol (E4) for menopause | grade=B (6.6/10) | evidence=8/10 | benefit=6.5/10 | safety=5/10 | category=Hormones & Endocrine | class=Prescription | legal_status=Rx (approved as contraceptive; menopause indication Phase 3 / filing) | last_reviewed=2026-07-11 | md=https://readofflabel.com/compound/estetrol-e4-for-menopause.md | html=https://readofflabel.com/compound/estetrol-e4-for-menopause/ - Romosozumab (Evenity) | grade=B (6.5/10) | evidence=8/10 | benefit=10/10 | safety=3.5/10 | category=Hormones & Endocrine | class=Prescription | legal_status=Rx (FDA-approved 2019 for postmenopausal osteoporosis at high fracture risk) | last_reviewed=2026-07-16 | md=https://readofflabel.com/compound/romosozumab-evenity.md | html=https://readofflabel.com/compound/romosozumab-evenity/ - T4 / NDT (levothyroxine, desiccated thyroid) | grade=B (6.4/10) | evidence=8/10 | benefit=5/10 | safety=5/10 | category=Hormones & Endocrine | class=Hormone | legal_status=Rx | last_reviewed=2026-07-11 | md=https://readofflabel.com/compound/t4-ndt-levothyroxine-desiccated-thyroid.md | html=https://readofflabel.com/compound/t4-ndt-levothyroxine-desiccated-thyroid/ - Anastrozole | grade=B (6.4/10) | evidence=8/10 | benefit=5/10 | safety=5/10 | category=Hormones & Endocrine | class=Hormone | legal_status=Rx | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/anastrozole.md | html=https://readofflabel.com/compound/anastrozole/ - Enclomiphene citrate | grade=B- (6.3/10) | evidence=6/10 | benefit=5/10 | safety=7/10 | category=Hormones & Endocrine | class=Hormone | legal_status=Investigational / compounded (Androxal was not FDA-approved; no FDA-approved US product) | last_reviewed=2026-07-11 | md=https://readofflabel.com/compound/enclomiphene-citrate.md | html=https://readofflabel.com/compound/enclomiphene-citrate/ - T3 (liothyronine) | grade=B- (6.2/10) | evidence=8/10 | benefit=8/10 | safety=3.5/10 | category=Hormones & Endocrine | class=Hormone | legal_status=Rx (Cytomel) | last_reviewed=2026-07-11 | md=https://readofflabel.com/compound/t3-liothyronine.md | html=https://readofflabel.com/compound/t3-liothyronine/ - Kisspeptin-10 | grade=B- (6.2/10) | evidence=4.5/10 | benefit=3.5/10 | safety=9/10 | category=Hormones & Endocrine | class=Peptide | legal_status=Research peptide; not FDA-approved | last_reviewed=2026-07-23 | md=https://readofflabel.com/compound/kisspeptin-10.md | html=https://readofflabel.com/compound/kisspeptin-10/ - DHEA | grade=B- (6.0/10) | evidence=6/10 | benefit=3.5/10 | safety=7/10 | category=Hormones & Endocrine | class=Hormone | legal_status=OTC (US); Rx in most other countries | last_reviewed=2026-07-11 | md=https://readofflabel.com/compound/dhea.md | html=https://readofflabel.com/compound/dhea/ - Pregnenolone | grade=C+ (5.5/10) | evidence=3/10 | benefit=3.5/10 | safety=9/10 | category=Hormones & Endocrine | class=Hormone | legal_status=OTC (US); Rx elsewhere | last_reviewed=2026-07-11 | md=https://readofflabel.com/compound/pregnenolone.md | html=https://readofflabel.com/compound/pregnenolone/ - Clomiphene citrate | grade=C+ (5.5/10) | evidence=6/10 | benefit=5/10 | safety=5/10 | category=Hormones & Endocrine | class=Hormone | legal_status=Rx (FDA-approved for female ovulatory infertility; male hypogonadism use off-label) | last_reviewed=2026-07-16 | md=https://readofflabel.com/compound/clomiphene-citrate.md | html=https://readofflabel.com/compound/clomiphene-citrate/ - PT-141 (Bremelanotide / Vyleesi) | grade=C+ (5.5/10) | evidence=6/10 | benefit=5/10 | safety=5/10 | category=Hormones & Endocrine | class=Prescription | legal_status=Rx (Vyleesi, on-demand); research peptide gray market for off-label male use | last_reviewed=2026-07-23 | md=https://readofflabel.com/compound/pt-141-bremelanotide-vyleesi.md | html=https://readofflabel.com/compound/pt-141-bremelanotide-vyleesi/ - Tribulus terrestris | grade=C+ (5.5/10) | evidence=3/10 | benefit=3.5/10 | safety=9/10 | category=Hormones & Endocrine | class=Herbal | legal_status=OTC | last_reviewed=2026-07-23 | md=https://readofflabel.com/compound/tribulus-terrestris.md | html=https://readofflabel.com/compound/tribulus-terrestris/ - Other aromatase inhibitors (letrozole / exemestane / formestane / arimistane) | grade=C+ (5.5/10) | evidence=6/10 | benefit=5/10 | safety=5/10 | category=Hormones & Endocrine | class=Hormone | legal_status=Rx for oncology/endocrine indications or gray-market supplement/research chemical; WADA S4 prohibited | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/other-aromatase-inhibitors-letrozole-exemestane-formestane-arimistane.md | html=https://readofflabel.com/compound/other-aromatase-inhibitors-letrozole-exemestane-formestane-arimistane/ - Other SERMs / anti-estrogens (tamoxifen / raloxifene / fulvestrant) | grade=C+ (5.5/10) | evidence=6/10 | benefit=5/10 | safety=5/10 | category=Hormones & Endocrine | class=Hormone | legal_status=Rx; WADA S4 prohibited | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/other-serms-anti-estrogens-tamoxifen-raloxifene-fulvestrant.md | html=https://readofflabel.com/compound/other-serms-anti-estrogens-tamoxifen-raloxifene-fulvestrant/ - Yohimbine | grade=C (4.9/10) | evidence=6/10 | benefit=5/10 | safety=3.5/10 | category=Hormones & Endocrine | class=Prescription | legal_status=OTC (yohimbe bark extract — variable potency); Rx (standardized yohimbine HCl) | last_reviewed=2026-07-23 | md=https://readofflabel.com/compound/yohimbine.md | html=https://readofflabel.com/compound/yohimbine/ - GnRH/LH-axis analogs for testosterone stimulation | grade=C (4.9/10) | evidence=6/10 | benefit=5/10 | safety=3.5/10 | category=Hormones & Endocrine | class=Peptide | legal_status=Rx/clinical peptide context; WADA S2 prohibited in males | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/gnrh-lh-axis-analogs-for-testosterone-stimulation.md | html=https://readofflabel.com/compound/gnrh-lh-axis-analogs-for-testosterone-stimulation/ - Pyrilutamide (KX-826) | grade=C (4.9/10) | evidence=3/10 | benefit=5/10 | safety=7/10 | category=Hormones & Endocrine | class=Prescription | legal_status=Investigational (China Phase 3; US Phase 2/3) | last_reviewed=2026-07-11 | md=https://readofflabel.com/compound/pyrilutamide-kx-826.md | html=https://readofflabel.com/compound/pyrilutamide-kx-826/ - Melanotan II (MT-II) | grade=C- (4.5/10) | evidence=6/10 | benefit=6.5/10 | safety=2/10 | category=Hormones & Endocrine | class=Prescription | legal_status=Not FDA-approved anywhere; research peptide; gray market | last_reviewed=2026-07-23 | md=https://readofflabel.com/compound/melanotan-ii-mt-ii.md | html=https://readofflabel.com/compound/melanotan-ii-mt-ii/ - ACTH / corticotrophin analogs | grade=D (3.3/10) | evidence=3/10 | benefit=3.5/10 | safety=3.5/10 | category=Hormones & Endocrine | class=Prescription | legal_status=Rx/diagnostic or narrow clinical use; WADA S2 prohibited | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/acth-corticotrophin-analogs.md | html=https://readofflabel.com/compound/acth-corticotrophin-analogs/ - Osilodrostat | grade=D- (2.5/10) | evidence=3/10 | benefit=2/10 | safety=2/10 | category=Hormones & Endocrine | class=Prescription | legal_status=Rx for Cushing disease in some jurisdictions; WADA S1 prohibited | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/osilodrostat.md | html=https://readofflabel.com/compound/osilodrostat/ - Fadogia agrestis | grade=F (2.0/10) | evidence=0/10 | benefit=5/10 | safety=3/10 | category=Hormones & Endocrine | class=Herbal | legal_status=OTC (supplement) | last_reviewed=2026-07-23 | md=https://readofflabel.com/compound/fadogia-agrestis.md | html=https://readofflabel.com/compound/fadogia-agrestis/ ## Immune & Inflammation (24) - Rifaximin (Xifaxan) | grade=A+ (8.4/10) | evidence=8/10 | benefit=8/10 | safety=9/10 | category=Immune & Inflammation | class=Prescription | legal_status=Rx | last_reviewed=2026-07-19 | md=https://readofflabel.com/compound/rifaximin-xifaxan.md | html=https://readofflabel.com/compound/rifaximin-xifaxan/ - Probiotics (multi-strain) | grade=A (8.0/10) | evidence=8/10 | benefit=5/10 | safety=9/10 | category=Immune & Inflammation | class=Supplement | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/probiotics-multi-strain.md | html=https://readofflabel.com/compound/probiotics-multi-strain/ - Saccharomyces boulardii | grade=A (8.0/10) | evidence=8/10 | benefit=5/10 | safety=9/10 | category=Immune & Inflammation | class=Supplement | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/saccharomyces-boulardii.md | html=https://readofflabel.com/compound/saccharomyces-boulardii/ - Vitamin C (ascorbic acid) | grade=A (8.0/10) | evidence=8/10 | benefit=5/10 | safety=9/10 | category=Immune & Inflammation | class=Supplement | legal_status=OTC (oral); Rx (IV high-dose pharmacy compounding) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/vitamin-c-ascorbic-acid.md | html=https://readofflabel.com/compound/vitamin-c-ascorbic-acid/ - Ginger (Zingiber officinale) | grade=A (8.0/10) | evidence=8/10 | benefit=5/10 | safety=9/10 | category=Immune & Inflammation | class=Supplement | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/ginger-zingiber-officinale.md | html=https://readofflabel.com/compound/ginger-zingiber-officinale/ - FMT (fecal microbiota transplantation) | grade=A- (7.7/10) | evidence=10/10 | benefit=8/10 | safety=5/10 | category=Immune & Inflammation | class=Prescription | legal_status=Rx only (OpenBiome closed 2024; now via Rebyota or Vowst); DIY FMT illegal and dangerous | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/fmt-fecal-microbiota-transplantation.md | html=https://readofflabel.com/compound/fmt-fecal-microbiota-transplantation/ - Butyrate (tributyrin / sodium butyrate) | grade=B+ (7.1/10) | evidence=6/10 | benefit=5/10 | safety=9/10 | category=Immune & Inflammation | class=Supplement | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/butyrate-tributyrin-sodium-butyrate.md | html=https://readofflabel.com/compound/butyrate-tributyrin-sodium-butyrate/ - Lactoferrin (bovine) | grade=B+ (7.1/10) | evidence=6/10 | benefit=5/10 | safety=9/10 | category=Immune & Inflammation | class=Supplement | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/lactoferrin-bovine.md | html=https://readofflabel.com/compound/lactoferrin-bovine/ - Akkermansia muciniphila (pasteurized) | grade=B (6.8/10) | evidence=6/10 | benefit=3.5/10 | safety=9/10 | category=Immune & Inflammation | class=Supplement | legal_status=OTC (Pendulum Glucose Control and similar in US) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/akkermansia-muciniphila-pasteurized.md | html=https://readofflabel.com/compound/akkermansia-muciniphila-pasteurized/ - 2'-fucosyllactose (2'-FL human milk oligosaccharide) | grade=B (6.8/10) | evidence=6/10 | benefit=3.5/10 | safety=9/10 | category=Immune & Inflammation | class=Supplement | legal_status=OTC / dietary ingredient | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/2-fucosyllactose-2-fl-human-milk-oligosaccharide.md | html=https://readofflabel.com/compound/2-fucosyllactose-2-fl-human-milk-oligosaccharide/ - Lactobacillus acidophilus | grade=B (6.8/10) | evidence=6/10 | benefit=3.5/10 | safety=9/10 | category=Immune & Inflammation | class=Supplement | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/lactobacillus-acidophilus.md | html=https://readofflabel.com/compound/lactobacillus-acidophilus/ - Prebiotics (inulin / FOS / GOS / partially hydrolyzed guar gum) | grade=B- (6.3/10) | evidence=6/10 | benefit=5/10 | safety=7/10 | category=Immune & Inflammation | class=Supplement | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/prebiotics-inulin-fos-gos-partially-hydrolyzed-guar-gum.md | html=https://readofflabel.com/compound/prebiotics-inulin-fos-gos-partially-hydrolyzed-guar-gum/ - Echinacea | grade=B- (6.2/10) | evidence=4.5/10 | benefit=3.5/10 | safety=9/10 | category=Immune & Inflammation | class=Herbal | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/echinacea.md | html=https://readofflabel.com/compound/echinacea/ - Beta-glucans (yeast / mushroom) | grade=B- (6.2/10) | evidence=4.5/10 | benefit=3.5/10 | safety=9/10 | category=Immune & Inflammation | class=Supplement | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/beta-glucans-yeast-mushroom.md | html=https://readofflabel.com/compound/beta-glucans-yeast-mushroom/ - Colostrum (bovine) | grade=B- (6.2/10) | evidence=4.5/10 | benefit=3.5/10 | safety=9/10 | category=Immune & Inflammation | class=Supplement | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/colostrum-bovine.md | html=https://readofflabel.com/compound/colostrum-bovine/ - Lycopene | grade=B- (6.2/10) | evidence=4.5/10 | benefit=3.5/10 | safety=9/10 | category=Immune & Inflammation | class=Herbal | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/lycopene.md | html=https://readofflabel.com/compound/lycopene/ - Shiitake (Lentinula edodes) | grade=B- (6.0/10) | evidence=6/10 | benefit=3.5/10 | safety=7/10 | category=Immune & Inflammation | class=Herbal | legal_status=OTC (food/supplement); Rx (IV lentinan in Japan) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/shiitake-lentinula-edodes.md | html=https://readofflabel.com/compound/shiitake-lentinula-edodes/ - Quercetin | grade=C+ (5.5/10) | evidence=3/10 | benefit=3.5/10 | safety=9/10 | category=Immune & Inflammation | class=Supplement | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/quercetin.md | html=https://readofflabel.com/compound/quercetin/ - Elderberry (Sambucus nigra) | grade=C+ (5.5/10) | evidence=3/10 | benefit=3.5/10 | safety=9/10 | category=Immune & Inflammation | class=Herbal | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/elderberry-sambucus-nigra.md | html=https://readofflabel.com/compound/elderberry-sambucus-nigra/ - Astragalus | grade=C+ (5.5/10) | evidence=3/10 | benefit=3.5/10 | safety=9/10 | category=Immune & Inflammation | class=Herbal | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/astragalus.md | html=https://readofflabel.com/compound/astragalus/ - Maitake (Grifola frondosa) | grade=C+ (5.3/10) | evidence=3/10 | benefit=2/10 | safety=9/10 | category=Immune & Inflammation | class=Herbal | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/maitake-grifola-frondosa.md | html=https://readofflabel.com/compound/maitake-grifola-frondosa/ - Reishi (Ganoderma lucidum) | grade=C (4.6/10) | evidence=4.5/10 | benefit=3.5/10 | safety=5/10 | category=Immune & Inflammation | class=Herbal | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/reishi-ganoderma-lucidum.md | html=https://readofflabel.com/compound/reishi-ganoderma-lucidum/ - Systemic glucocorticoids (prednisone / dexamethasone / triamcinolone) | grade=C- (4.3/10) | evidence=6/10 | benefit=5/10 | safety=2/10 | category=Immune & Inflammation | class=Prescription | legal_status=Rx; WADA S9 prohibited in competition by oral, rectal, injectable or other systemic routes | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/systemic-glucocorticoids-prednisone-dexamethasone-triamcinolone.md | html=https://readofflabel.com/compound/systemic-glucocorticoids-prednisone-dexamethasone-triamcinolone/ - Larazotide acetate (AT-1001) | grade=D+ (3.4/10) | evidence=3/10 | benefit=3/10 | safety=4/10 | category=Immune & Inflammation | class=Supplement | legal_status=Not FDA-approved; 9 Meters discontinued development; gray-market research peptide | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/larazotide-acetate-at-1001.md | html=https://readofflabel.com/compound/larazotide-acetate-at-1001/ ## Longevity — Peptides (6) - GHK-Cu (copper peptide) | grade=B+ (7.1/10) | evidence=6/10 | benefit=5/10 | safety=9/10 | category=Longevity — Peptides | class=Peptide | legal_status=OTC (topical); injectable formerly compounded — now Category 2 on FDA 503A list for injection (prohibited) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/ghk-cu-copper-peptide.md | html=https://readofflabel.com/compound/ghk-cu-copper-peptide/ - MOTS-c | grade=C+ (5.5/10) | evidence=2.5/10 | benefit=5/10 | safety=9/10 | category=Longevity — Peptides | class=Peptide | legal_status=Research chemical; PCAC voted 7-5 (two abstentions) in favour of adding MOTS-c to the 503A bulks list (Jul 23-24, 2026) — advisory only, not an FDA approval or a final compounding decision | last_reviewed=2026-07-27 | md=https://readofflabel.com/compound/mots-c.md | html=https://readofflabel.com/compound/mots-c/ - Epithalon (epitalon) | grade=C+ (5.3/10) | evidence=2/10 | benefit=5/10 | safety=9/10 | category=Longevity — Peptides | class=Peptide | legal_status=Research chemical; PCAC voted 7-5 (one abstention) in favour of adding epitalon to the 503A bulks list, for insomnia (Jul 23-24, 2026) — advisory only, not an FDA approval or a final compounding decision | last_reviewed=2026-07-27 | md=https://readofflabel.com/compound/epithalon-epitalon.md | html=https://readofflabel.com/compound/epithalon-epitalon/ - Pinealon (EDR tripeptide / Glu-Asp-Arg) | grade=C+ (5.3/10) | evidence=2/10 | benefit=5/10 | safety=9/10 | category=Longevity — Peptides | class=Peptide | legal_status=Research chemical (not FDA-approved) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/pinealon-edr-tripeptide-glu-asp-arg.md | html=https://readofflabel.com/compound/pinealon-edr-tripeptide-glu-asp-arg/ - Thymalin | grade=C+ (5.3/10) | evidence=2/10 | benefit=5/10 | safety=9/10 | category=Longevity — Peptides | class=Peptide | legal_status=Research chemical | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/thymalin.md | html=https://readofflabel.com/compound/thymalin/ - Humanin | grade=C+ (5.3/10) | evidence=2/10 | benefit=5/10 | safety=9/10 | category=Longevity — Peptides | class=Peptide | legal_status=Research chemical | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/humanin.md | html=https://readofflabel.com/compound/humanin/ ## Longevity — Pharma (Off-Label) (3) - Metformin | grade=B+ (7.2/10) | evidence=8/10 | benefit=5/10 | safety=7/10 | category=Longevity — Pharma (Off-Label) | class=Prescription | legal_status=Rx (off-label for longevity) | last_reviewed=2026-07-01 | md=https://readofflabel.com/compound/metformin.md | html=https://readofflabel.com/compound/metformin/ - Acarbose | grade=B- (6.3/10) | evidence=6/10 | benefit=5/10 | safety=7/10 | category=Longevity — Pharma (Off-Label) | class=Prescription | legal_status=Rx (T2D); often OTC outside US | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/acarbose.md | html=https://readofflabel.com/compound/acarbose/ - Rapamycin (sirolimus) | grade=C (5.0/10) | evidence=4.5/10 | benefit=6.5/10 | safety=5/10 | category=Longevity — Pharma (Off-Label) | class=Prescription | legal_status=Rx (off-label for longevity) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/rapamycin-sirolimus.md | html=https://readofflabel.com/compound/rapamycin-sirolimus/ ## Longevity — Senolytics & Polyphenols (7) - Cocoa flavanols (Theobroma cacao) | grade=A- (7.7/10) | evidence=8/10 | benefit=3.5/10 | safety=9/10 | category=Longevity — Senolytics & Polyphenols | class=Supplement | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/cocoa-flavanols-theobroma-cacao.md | html=https://readofflabel.com/compound/cocoa-flavanols-theobroma-cacao/ - Spermidine | grade=B+ (7.1/10) | evidence=6/10 | benefit=5/10 | safety=9/10 | category=Longevity — Senolytics & Polyphenols | class=Supplement | legal_status=OTC (wheat germ extract; synthetic) | last_reviewed=2026-07-16 | md=https://readofflabel.com/compound/spermidine.md | html=https://readofflabel.com/compound/spermidine/ - Fisetin | grade=B- (6.2/10) | evidence=4/10 | benefit=5/10 | safety=9/10 | category=Longevity — Senolytics & Polyphenols | class=Supplement | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/fisetin.md | html=https://readofflabel.com/compound/fisetin/ - Resveratrol | grade=B- (6.2/10) | evidence=4.5/10 | benefit=3.5/10 | safety=9/10 | category=Longevity — Senolytics & Polyphenols | class=Supplement | legal_status=OTC | last_reviewed=2026-07-11 | md=https://readofflabel.com/compound/resveratrol.md | html=https://readofflabel.com/compound/resveratrol/ - Senolytics (D+Q combo) | grade=C+ (5.5/10) | evidence=6/10 | benefit=5/10 | safety=5/10 | category=Longevity — Senolytics & Polyphenols | class=Prescription | legal_status=Rx (dasatinib is oncology drug — off-label use) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/senolytics-d-q-combo.md | html=https://readofflabel.com/compound/senolytics-d-q-combo/ - Luteolin | grade=C (4.8/10) | evidence=2/10 | benefit=2/10 | safety=9/10 | category=Longevity — Senolytics & Polyphenols | class=Supplement | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/luteolin.md | html=https://readofflabel.com/compound/luteolin/ - Pterostilbene | grade=C- (4.5/10) | evidence=2.5/10 | benefit=3.5/10 | safety=7/10 | category=Longevity — Senolytics & Polyphenols | class=Supplement | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/pterostilbene.md | html=https://readofflabel.com/compound/pterostilbene/ ## Longevity — Supplements (19) - Lutein + Zeaxanthin | grade=A+ (8.2/10) | evidence=8/10 | benefit=6.5/10 | safety=9/10 | category=Longevity — Supplements | class=Herbal | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/lutein-zeaxanthin.md | html=https://readofflabel.com/compound/lutein-zeaxanthin/ - Tretinoin (all-trans retinoic acid) | grade=A (8.0/10) | evidence=10/10 | benefit=10/10 | safety=5/10 | category=Longevity — Supplements | class=Prescription | legal_status=Rx (tretinoin); adapalene 0.1% OTC since 2016 | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/tretinoin-all-trans-retinoic-acid.md | html=https://readofflabel.com/compound/tretinoin-all-trans-retinoic-acid/ - NAD+ / NMN / NR | grade=B+ (7.1/10) | evidence=6/10 | benefit=5/10 | safety=9/10 | category=Longevity — Supplements | class=Supplement | legal_status=OTC | last_reviewed=2026-07-27 | md=https://readofflabel.com/compound/nad-nmn-nr.md | html=https://readofflabel.com/compound/nad-nmn-nr/ - Alpha-ketoglutarate (Ca-AKG) | grade=B+ (7.1/10) | evidence=6/10 | benefit=5/10 | safety=9/10 | category=Longevity — Supplements | class=Supplement | legal_status=OTC (Rejuvant) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/alpha-ketoglutarate-ca-akg.md | html=https://readofflabel.com/compound/alpha-ketoglutarate-ca-akg/ - Glycine + NAC (GlyNAC) | grade=B+ (7.1/10) | evidence=6/10 | benefit=5/10 | safety=9/10 | category=Longevity — Supplements | class=Supplement | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/glycine-nac-glynac.md | html=https://readofflabel.com/compound/glycine-nac-glynac/ - Glycine (longevity / metabolic) | grade=B+ (7.1/10) | evidence=6/10 | benefit=5/10 | safety=9/10 | category=Longevity — Supplements | class=Supplement | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/glycine-longevity-metabolic.md | html=https://readofflabel.com/compound/glycine-longevity-metabolic/ - Sulforaphane | grade=B+ (7.1/10) | evidence=6/10 | benefit=5/10 | safety=9/10 | category=Longevity — Supplements | class=Supplement | legal_status=OTC (broccoli sprout extract; preformed sulforaphane products include Avmacol, Prostaphane, BroccoMax) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/sulforaphane.md | html=https://readofflabel.com/compound/sulforaphane/ - Astaxanthin | grade=B+ (7.1/10) | evidence=6/10 | benefit=5/10 | safety=9/10 | category=Longevity — Supplements | class=Herbal | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/astaxanthin.md | html=https://readofflabel.com/compound/astaxanthin/ - ACE inhibitors / ARBs (telmisartan / losartan / enalapril) | grade=B- (6.3/10) | evidence=6/10 | benefit=5/10 | safety=7/10 | category=Longevity — Supplements | class=Prescription | legal_status=Rx (FDA-approved generics for hypertension, heart failure, CKD; off-label as geroprotectors) | last_reviewed=2026-07-23 | md=https://readofflabel.com/compound/ace-inhibitors-arbs-telmisartan-losartan-enalapril.md | html=https://readofflabel.com/compound/ace-inhibitors-arbs-telmisartan-losartan-enalapril/ - SGLT2 inhibitors (canagliflozin / empagliflozin / dapagliflozin) | grade=C+ (5.5/10) | evidence=6/10 | benefit=5/10 | safety=5/10 | category=Longevity — Supplements | class=Prescription | legal_status=Rx (FDA-approved for T2D, heart failure, CKD — Invokana / Jardiance / Farxiga; off-label as a geroprotector) | last_reviewed=2026-07-23 | md=https://readofflabel.com/compound/sglt2-inhibitors-canagliflozin-empagliflozin-dapagliflozin.md | html=https://readofflabel.com/compound/sglt2-inhibitors-canagliflozin-empagliflozin-dapagliflozin/ - 17-alpha estradiol | grade=C- (4.5/10) | evidence=2/10 | benefit=5/10 | safety=7/10 | category=Longevity — Supplements | class=Research chemical | legal_status=Research chemical / compounded | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/17-alpha-estradiol.md | html=https://readofflabel.com/compound/17-alpha-estradiol/ - Klotho | grade=D+ (3.7/10) | evidence=2/10 | benefit=5/10 | safety=5/10 | category=Longevity — Supplements | class=Supplement | legal_status=Experimental | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/klotho.md | html=https://readofflabel.com/compound/klotho/ - GDF11 | grade=D+ (3.7/10) | evidence=2/10 | benefit=5/10 | safety=5/10 | category=Longevity — Supplements | class=Supplement | legal_status=Experimental | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/gdf11.md | html=https://readofflabel.com/compound/gdf11/ - Censavudine / TPN-101 (LINE-1 suppression) | grade=D+ (3.7/10) | evidence=2/10 | benefit=5/10 | safety=5/10 | category=Longevity — Supplements | class=Prescription | legal_status=Investigational (repurposing; ARPA-H PROSPR-funded) | last_reviewed=2026-07-11 | md=https://readofflabel.com/compound/censavudine-tpn-101-line-1-suppression.md | html=https://readofflabel.com/compound/censavudine-tpn-101-line-1-suppression/ - C60 (carbon 60 / buckminsterfullerene) | grade=D (3.3/10) | evidence=3/10 | benefit=2/10 | safety=4/10 | category=Longevity — Supplements | class=Research chemical | legal_status=Research chemical / OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/c60-carbon-60-buckminsterfullerene.md | html=https://readofflabel.com/compound/c60-carbon-60-buckminsterfullerene/ - Plasma exchange / young plasma | grade=D (3.3/10) | evidence=3/10 | benefit=3.5/10 | safety=3.5/10 | category=Longevity — Supplements | class=Supplement | legal_status=Research/clinical setting | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/plasma-exchange-young-plasma.md | html=https://readofflabel.com/compound/plasma-exchange-young-plasma/ - NDGA (nordihydroguaiaretic acid) | grade=D (3.3/10) | evidence=3/10 | benefit=3.5/10 | safety=3.5/10 | category=Longevity — Supplements | class=Supplement | legal_status=Supplement (chaparral); FDA has warned against chaparral for hepatotoxicity; not approved for any longevity use | last_reviewed=2026-07-23 | md=https://readofflabel.com/compound/ndga-nordihydroguaiaretic-acid.md | html=https://readofflabel.com/compound/ndga-nordihydroguaiaretic-acid/ - Yamanaka factors / partial reprogramming | grade=D (3.1/10) | evidence=2/10 | benefit=5/10 | safety=3.5/10 | category=Longevity — Supplements | class=Supplement | legal_status=Research only | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/yamanaka-factors-partial-reprogramming.md | html=https://readofflabel.com/compound/yamanaka-factors-partial-reprogramming/ - ER-100 (partial epigenetic reprogramming) | grade=D (2.9/10) | evidence=2/10 | benefit=8/10 | safety=2/10 | category=Longevity — Supplements | class=Supplement | legal_status=Investigational (Phase 1; first patient dosed Jun 9 2026) | last_reviewed=2026-07-11 | md=https://readofflabel.com/compound/er-100-partial-epigenetic-reprogramming.md | html=https://readofflabel.com/compound/er-100-partial-epigenetic-reprogramming/ ## Metabolic Health (65) - Rosuvastatin / atorvastatin (statins) | grade=S (8.8/10) | evidence=10/10 | benefit=10/10 | safety=7/10 | category=Metabolic Health | class=Prescription | legal_status=Rx | last_reviewed=2026-07-16 | md=https://readofflabel.com/compound/rosuvastatin-atorvastatin-statins.md | html=https://readofflabel.com/compound/rosuvastatin-atorvastatin-statins/ - PCSK9 inhibitors (evolocumab / alirocumab / inclisiran) | grade=S (8.7/10) | evidence=8/10 | benefit=10/10 | safety=9/10 | category=Metabolic Health | class=Prescription | legal_status=Rx (expensive at list; list prices now lower — ~$500-600/month after 2018 price cuts); enlicitide (Lipfendra) adds an oral option, FDA-approved July 2026 | last_reviewed=2026-07-23 | md=https://readofflabel.com/compound/pcsk9-inhibitors-evolocumab-alirocumab-inclisiran.md | html=https://readofflabel.com/compound/pcsk9-inhibitors-evolocumab-alirocumab-inclisiran/ - VO2 max / HIIT | grade=S (8.5/10) | evidence=10/10 | benefit=8/10 | safety=7/10 | category=Metabolic Health | class=Protocol | legal_status=N/A | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/vo2-max-hiit.md | html=https://readofflabel.com/compound/vo2-max-hiit/ - Ezetimibe | grade=A+ (8.4/10) | evidence=8/10 | benefit=5/10 | safety=10/10 | category=Metabolic Health | class=Prescription | legal_status=Rx (generic) | last_reviewed=2026-07-16 | md=https://readofflabel.com/compound/ezetimibe.md | html=https://readofflabel.com/compound/ezetimibe/ - Lp(a)-lowering therapies (olpasiran / pelacarsen / lepodisiran / zerlasiran / muvalaplin) | grade=A (7.9/10) | evidence=8/10 | benefit=10/10 | safety=7/10 | category=Metabolic Health | class=Supplement | legal_status=Investigational (pelacarsen Lp(a)HORIZON CVOT readout expected 2026; olpasiran OCEAN(a) Outcomes ongoing) | last_reviewed=2026-07-11 | md=https://readofflabel.com/compound/lp-a-lowering-therapies-olpasiran-pelacarsen-lepodisiran-zerlasiran-muvalaplin.md | html=https://readofflabel.com/compound/lp-a-lowering-therapies-olpasiran-pelacarsen-lepodisiran-zerlasiran-muvalaplin/ - Sauna (Finnish/dry) | grade=A- (7.6/10) | evidence=8/10 | benefit=8/10 | safety=7/10 | category=Metabolic Health | class=Protocol | legal_status=N/A | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/sauna-finnish-dry.md | html=https://readofflabel.com/compound/sauna-finnish-dry/ - Icosapent ethyl (Vascepa) | grade=A- (7.6/10) | evidence=8/10 | benefit=8/10 | safety=7/10 | category=Metabolic Health | class=Prescription | legal_status=Rx (generic available since 2022) | last_reviewed=2026-07-16 | md=https://readofflabel.com/compound/icosapent-ethyl-vascepa.md | html=https://readofflabel.com/compound/icosapent-ethyl-vascepa/ - Obicetrapib | grade=A- (7.6/10) | evidence=8/10 | benefit=8/10 | safety=7/10 | category=Metabolic Health | class=Prescription | legal_status=Investigational (NewAmsterdam/Menarini; EMA marketing-authorization applications accepted for obicetrapib and obicetrapib/ezetimibe in primary hypercholesterolaemia, EU decision expected 2H2026; PREVAIL CVOT readout expected 2026-2027) | last_reviewed=2026-07-11 | md=https://readofflabel.com/compound/obicetrapib.md | html=https://readofflabel.com/compound/obicetrapib/ - Zone 2 cardio | grade=B+ (7.3/10) | evidence=6/10 | benefit=6.5/10 | safety=9/10 | category=Metabolic Health | class=Protocol | legal_status=N/A | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/zone-2-cardio.md | html=https://readofflabel.com/compound/zone-2-cardio/ - Altitude training / intermittent hypoxia (IHT) | grade=B+ (7.2/10) | evidence=8/10 | benefit=5/10 | safety=7/10 | category=Metabolic Health | class=Protocol | legal_status=N/A | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/altitude-training-intermittent-hypoxia-iht.md | html=https://readofflabel.com/compound/altitude-training-intermittent-hypoxia-iht/ - Time-restricted eating (TRE) | grade=B+ (7.1/10) | evidence=6/10 | benefit=5/10 | safety=9/10 | category=Metabolic Health | class=Protocol | legal_status=N/A | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/time-restricted-eating-tre.md | html=https://readofflabel.com/compound/time-restricted-eating-tre/ - Retatrutide | grade=B+ (7.1/10) | evidence=8/10 | benefit=10/10 | safety=5/10 | category=Metabolic Health | class=Prescription | legal_status=Investigational (Phase 3) | last_reviewed=2026-07-11 | md=https://readofflabel.com/compound/retatrutide.md | html=https://readofflabel.com/compound/retatrutide/ - Citrus bergamot | grade=B+ (7.1/10) | evidence=6/10 | benefit=5/10 | safety=9/10 | category=Metabolic Health | class=Herbal | legal_status=OTC | last_reviewed=2026-07-16 | md=https://readofflabel.com/compound/citrus-bergamot.md | html=https://readofflabel.com/compound/citrus-bergamot/ - TUDCA (tauroursodeoxycholic acid) | grade=B+ (7.1/10) | evidence=6/10 | benefit=5/10 | safety=9/10 | category=Metabolic Health | class=Supplement | legal_status=Approved in China and Italy for cholestatic disease; was an active ingredient (as taurursodiol) in FDA-approved Relyvrio/AMX0035 for ALS — withdrawn after PHOENIX Phase 3 failure; sold OTC in US as dietary supplement (gray area) | last_reviewed=2026-07-11 | md=https://readofflabel.com/compound/tudca-tauroursodeoxycholic-acid.md | html=https://readofflabel.com/compound/tudca-tauroursodeoxycholic-acid/ - Orlistat | grade=B (6.9/10) | evidence=8/10 | benefit=3.5/10 | safety=7/10 | category=Metabolic Health | class=Prescription | legal_status=OTC (Alli) / Rx (Xenical) | last_reviewed=2026-07-11 | md=https://readofflabel.com/compound/orlistat.md | html=https://readofflabel.com/compound/orlistat/ - Semaglutide | grade=B (6.8/10) | evidence=8/10 | benefit=8/10 | safety=5/10 | category=Metabolic Health | class=Prescription | legal_status=Rx | last_reviewed=2026-07-11 | md=https://readofflabel.com/compound/semaglutide.md | html=https://readofflabel.com/compound/semaglutide/ - Tirzepatide | grade=B (6.8/10) | evidence=8/10 | benefit=8/10 | safety=5/10 | category=Metabolic Health | class=Prescription | legal_status=Rx | last_reviewed=2026-07-11 | md=https://readofflabel.com/compound/tirzepatide.md | html=https://readofflabel.com/compound/tirzepatide/ - Cagrilintide | grade=B (6.8/10) | evidence=8/10 | benefit=8/10 | safety=5/10 | category=Metabolic Health | class=Supplement | legal_status=Investigational; CagriSema NDA filed with FDA Dec 18, 2025 (decision expected ~Oct 2026) | last_reviewed=2026-07-23 | md=https://readofflabel.com/compound/cagrilintide.md | html=https://readofflabel.com/compound/cagrilintide/ - Setmelanotide | grade=B (6.8/10) | evidence=8/10 | benefit=8/10 | safety=5/10 | category=Metabolic Health | class=Prescription | legal_status=Rx (restricted use; expanded Mar 2026 to acquired hypothalamic obesity) | last_reviewed=2026-07-11 | md=https://readofflabel.com/compound/setmelanotide.md | html=https://readofflabel.com/compound/setmelanotide/ - Orforglipron | grade=B (6.8/10) | evidence=8/10 | benefit=8/10 | safety=5/10 | category=Metabolic Health | class=Prescription | legal_status=Rx (FDA-approved April 1, 2026 as Foundayo for chronic weight management) | last_reviewed=2026-07-23 | md=https://readofflabel.com/compound/orforglipron.md | html=https://readofflabel.com/compound/orforglipron/ - Survodutide | grade=B (6.8/10) | evidence=8/10 | benefit=8/10 | safety=5/10 | category=Metabolic Health | class=Prescription | legal_status=Investigational (Phase 3) | last_reviewed=2026-07-11 | md=https://readofflabel.com/compound/survodutide.md | html=https://readofflabel.com/compound/survodutide/ - Maridebart cafraglutide (MariTide) | grade=B (6.8/10) | evidence=8/10 | benefit=8/10 | safety=5/10 | category=Metabolic Health | class=Prescription | legal_status=Investigational (Phase 3) | last_reviewed=2026-07-11 | md=https://readofflabel.com/compound/maridebart-cafraglutide-maritide.md | html=https://readofflabel.com/compound/maridebart-cafraglutide-maritide/ - Mazdutide (IBI362) | grade=B (6.8/10) | evidence=8/10 | benefit=8/10 | safety=5/10 | category=Metabolic Health | class=Prescription | legal_status=Approved in China (June 2025) for chronic weight management; FDA filing TBD | last_reviewed=2026-07-16 | md=https://readofflabel.com/compound/mazdutide-ibi362.md | html=https://readofflabel.com/compound/mazdutide-ibi362/ - Aspirin (low-dose) | grade=B (6.8/10) | evidence=8/10 | benefit=8/10 | safety=5/10 | category=Metabolic Health | class=Prescription | legal_status=OTC | last_reviewed=2026-07-27 | md=https://readofflabel.com/compound/aspirin-low-dose.md | html=https://readofflabel.com/compound/aspirin-low-dose/ - Garlic extract (aged / allicin) | grade=B (6.8/10) | evidence=6/10 | benefit=3.5/10 | safety=9/10 | category=Metabolic Health | class=Herbal | legal_status=OTC | last_reviewed=2026-07-23 | md=https://readofflabel.com/compound/garlic-extract-aged-allicin.md | html=https://readofflabel.com/compound/garlic-extract-aged-allicin/ - Allulose | grade=B (6.8/10) | evidence=6/10 | benefit=3.5/10 | safety=9/10 | category=Metabolic Health | class=Supplement | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/allulose.md | html=https://readofflabel.com/compound/allulose/ - Monk fruit (mogroside V) | grade=B (6.8/10) | evidence=6/10 | benefit=3.5/10 | safety=9/10 | category=Metabolic Health | class=Supplement | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/monk-fruit-mogroside-v.md | html=https://readofflabel.com/compound/monk-fruit-mogroside-v/ - Olezarsen / Plozasiran (ApoC-III inhibitors) | grade=B (6.8/10) | evidence=8/10 | benefit=8/10 | safety=5/10 | category=Metabolic Health | class=Prescription | legal_status=Rx (olezarsen approved US/EU for FCS as Tryngolza); severe HTG under FDA review | last_reviewed=2026-07-27 | md=https://readofflabel.com/compound/olezarsen-plozasiran-apoc-iii-inhibitors.md | html=https://readofflabel.com/compound/olezarsen-plozasiran-apoc-iii-inhibitors/ - Liraglutide | grade=B (6.6/10) | evidence=8/10 | benefit=6.5/10 | safety=5/10 | category=Metabolic Health | class=Prescription | legal_status=Rx | last_reviewed=2026-07-11 | md=https://readofflabel.com/compound/liraglutide.md | html=https://readofflabel.com/compound/liraglutide/ - Evinacumab / Zodasiran (ANGPTL3 inhibitors) | grade=B (6.6/10) | evidence=8/10 | benefit=6.5/10 | safety=5/10 | category=Metabolic Health | class=Prescription | legal_status=Rx (evinacumab approved for HoFH as Evkeeza); zodasiran investigational (Phase 3) | last_reviewed=2026-07-11 | md=https://readofflabel.com/compound/evinacumab-zodasiran-angptl3-inhibitors.md | html=https://readofflabel.com/compound/evinacumab-zodasiran-angptl3-inhibitors/ - Dulaglutide | grade=B (6.4/10) | evidence=8/10 | benefit=5/10 | safety=5/10 | category=Metabolic Health | class=Prescription | legal_status=Rx | last_reviewed=2026-07-11 | md=https://readofflabel.com/compound/dulaglutide.md | html=https://readofflabel.com/compound/dulaglutide/ - Contrave (bupropion + naltrexone) | grade=B (6.4/10) | evidence=8/10 | benefit=5/10 | safety=5/10 | category=Metabolic Health | class=Prescription | legal_status=Rx | last_reviewed=2026-07-11 | md=https://readofflabel.com/compound/contrave-bupropion-naltrexone.md | html=https://readofflabel.com/compound/contrave-bupropion-naltrexone/ - Intermittent fasting (general) | grade=B- (6.3/10) | evidence=6/10 | benefit=5/10 | safety=7/10 | category=Metabolic Health | class=Protocol | legal_status=N/A | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/intermittent-fasting-general.md | html=https://readofflabel.com/compound/intermittent-fasting-general/ - Fasting-mimicking diet (FMD / ProLon) | grade=B- (6.3/10) | evidence=6/10 | benefit=5/10 | safety=7/10 | category=Metabolic Health | class=Protocol | legal_status=Commercial (ProLon) or DIY | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/fasting-mimicking-diet-fmd-prolon.md | html=https://readofflabel.com/compound/fasting-mimicking-diet-fmd-prolon/ - Berberine | grade=B- (6.3/10) | evidence=6/10 | benefit=5/10 | safety=7/10 | category=Metabolic Health | class=Supplement | legal_status=OTC | last_reviewed=2026-07-11 | md=https://readofflabel.com/compound/berberine.md | html=https://readofflabel.com/compound/berberine/ - Pramlintide | grade=B- (6.1/10) | evidence=8/10 | benefit=3.5/10 | safety=5/10 | category=Metabolic Health | class=Prescription | legal_status=Rx | last_reviewed=2026-07-11 | md=https://readofflabel.com/compound/pramlintide.md | html=https://readofflabel.com/compound/pramlintide/ - Phentermine | grade=B- (6.0/10) | evidence=8/10 | benefit=6.5/10 | safety=3.5/10 | category=Metabolic Health | class=Prescription | legal_status=Rx (Schedule IV) | last_reviewed=2026-07-11 | md=https://readofflabel.com/compound/phentermine.md | html=https://readofflabel.com/compound/phentermine/ - Bempedoic acid | grade=B- (5.9/10) | evidence=7/10 | benefit=5/10 | safety=5/10 | category=Metabolic Health | class=Prescription | legal_status=Rx (Nexletol; combo with ezetimibe = Nexlizet) | last_reviewed=2026-07-16 | md=https://readofflabel.com/compound/bempedoic-acid.md | html=https://readofflabel.com/compound/bempedoic-acid/ - Amycretin (zenagamtide) | grade=B- (5.9/10) | evidence=6/10 | benefit=8/10 | safety=5/10 | category=Metabolic Health | class=Prescription | legal_status=Investigational (Phase 3 initiated Q1 2026) | last_reviewed=2026-07-11 | md=https://readofflabel.com/compound/amycretin-zenagamtide.md | html=https://readofflabel.com/compound/amycretin-zenagamtide/ - Eloralintide | grade=B- (5.9/10) | evidence=6/10 | benefit=8/10 | safety=5/10 | category=Metabolic Health | class=Prescription | legal_status=Investigational (Phase 3) | last_reviewed=2026-07-11 | md=https://readofflabel.com/compound/eloralintide.md | html=https://readofflabel.com/compound/eloralintide/ - Enicepatide (CT388) | grade=B- (5.9/10) | evidence=6/10 | benefit=8/10 | safety=5/10 | category=Metabolic Health | class=Prescription | legal_status=Investigational (Phase 3 initiated 2026) | last_reviewed=2026-07-11 | md=https://readofflabel.com/compound/enicepatide-ct388.md | html=https://readofflabel.com/compound/enicepatide-ct388/ - Topiramate | grade=B- (5.8/10) | evidence=8/10 | benefit=5/10 | safety=3.5/10 | category=Metabolic Health | class=Prescription | legal_status=Rx | last_reviewed=2026-07-11 | md=https://readofflabel.com/compound/topiramate.md | html=https://readofflabel.com/compound/topiramate/ - Niacin (nicotinic acid) | grade=B- (5.8/10) | evidence=8/10 | benefit=5/10 | safety=3.5/10 | category=Metabolic Health | class=Prescription | legal_status=Rx (Niaspan extended release); OTC (immediate release / 'flush-free' inositol hexanicotinate — largely inactive on lipids) | last_reviewed=2026-07-16 | md=https://readofflabel.com/compound/niacin-nicotinic-acid.md | html=https://readofflabel.com/compound/niacin-nicotinic-acid/ - Bimagrumab | grade=C+ (5.7/10) | evidence=6/10 | benefit=6.5/10 | safety=5/10 | category=Metabolic Health | class=Prescription | legal_status=Investigational | last_reviewed=2026-07-11 | md=https://readofflabel.com/compound/bimagrumab.md | html=https://readofflabel.com/compound/bimagrumab/ - FGF21 analogs (efruxifermin / pegozafermin / efimosfermin) | grade=C+ (5.7/10) | evidence=6/10 | benefit=6.5/10 | safety=5/10 | category=Metabolic Health | class=Supplement | legal_status=Investigational (Phase 3 MASH programs; no FDA-approved product) | last_reviewed=2026-07-11 | md=https://readofflabel.com/compound/fgf21-analogs-efruxifermin-pegozafermin-efimosfermin.md | html=https://readofflabel.com/compound/fgf21-analogs-efruxifermin-pegozafermin-efimosfermin/ - Petrelintide (ZP8396) | grade=C+ (5.7/10) | evidence=6/10 | benefit=6.5/10 | safety=5/10 | category=Metabolic Health | class=Supplement | legal_status=Investigational (Phase 3 planned H2 2026) | last_reviewed=2026-07-11 | md=https://readofflabel.com/compound/petrelintide-zp8396.md | html=https://readofflabel.com/compound/petrelintide-zp8396/ - Elecoglipron (AZD5004 / ECC5004) | grade=C+ (5.7/10) | evidence=6/10 | benefit=6.5/10 | safety=5/10 | category=Metabolic Health | class=Prescription | legal_status=Investigational (Phase 3 initiated -- Embold trial, n=4,500, recruiting since Jun 29 2026) | last_reviewed=2026-07-23 | md=https://readofflabel.com/compound/elecoglipron-azd5004-ecc5004.md | html=https://readofflabel.com/compound/elecoglipron-azd5004-ecc5004/ - Clenbuterol | grade=C+ (5.6/10) | evidence=8/10 | benefit=8/10 | safety=2/10 | category=Metabolic Health | class=Prescription | legal_status=Not approved in US for human use; Rx elsewhere for asthma; banned in sport | last_reviewed=2026-07-16 | md=https://readofflabel.com/compound/clenbuterol.md | html=https://readofflabel.com/compound/clenbuterol/ - Red yeast rice | grade=C+ (5.5/10) | evidence=6/10 | benefit=5/10 | safety=5/10 | category=Metabolic Health | class=Herbal | legal_status=OTC (US; EU heavily restricted since 2022) | last_reviewed=2026-07-16 | md=https://readofflabel.com/compound/red-yeast-rice.md | html=https://readofflabel.com/compound/red-yeast-rice/ - Naltrexone (low dose, LDN) | grade=C+ (5.3/10) | evidence=3/10 | benefit=2/10 | safety=9/10 | category=Metabolic Health | class=Prescription | legal_status=Rx (off-label; compounded) | last_reviewed=2026-07-16 | md=https://readofflabel.com/compound/naltrexone-low-dose-ldn.md | html=https://readofflabel.com/compound/naltrexone-low-dose-ldn/ - Cinnamon (Cinnamomum cassia / verum) | grade=C+ (5.2/10) | evidence=6/10 | benefit=3.5/10 | safety=5/10 | category=Metabolic Health | class=Supplement | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/cinnamon-cinnamomum-cassia-verum.md | html=https://readofflabel.com/compound/cinnamon-cinnamomum-cassia-verum/ - DNP (2,4-dinitrophenol) | grade=C (5.1/10) | evidence=8/10 | benefit=10/10 | safety=0/10 | category=Metabolic Health | class=Prescription | legal_status=Illegal for human consumption (banned by FDA 1938) | last_reviewed=2026-07-16 | md=https://readofflabel.com/compound/dnp-2-4-dinitrophenol.md | html=https://readofflabel.com/compound/dnp-2-4-dinitrophenol/ - CLA (conjugated linoleic acid) | grade=C (5.1/10) | evidence=4.5/10 | benefit=2/10 | safety=7/10 | category=Metabolic Health | class=Supplement | legal_status=OTC | last_reviewed=2026-07-16 | md=https://readofflabel.com/compound/cla-conjugated-linoleic-acid.md | html=https://readofflabel.com/compound/cla-conjugated-linoleic-acid/ - Nattokinase | grade=C (4.9/10) | evidence=3/10 | benefit=5/10 | safety=7/10 | category=Metabolic Health | class=Prescription | legal_status=OTC | last_reviewed=2026-07-16 | md=https://readofflabel.com/compound/nattokinase.md | html=https://readofflabel.com/compound/nattokinase/ - Extended fasting (24-72h+) | grade=C (4.6/10) | evidence=4/10 | benefit=5/10 | safety=5/10 | category=Metabolic Health | class=Protocol | legal_status=N/A | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/extended-fasting-24-72h.md | html=https://readofflabel.com/compound/extended-fasting-24-72h/ - Other beta-2 agonists (salbutamol / formoterol / salmeterol / terbutaline) | grade=C (4.6/10) | evidence=6/10 | benefit=3.5/10 | safety=3.5/10 | category=Metabolic Health | class=Prescription | legal_status=Rx asthma/COPD drugs or region-specific agents; WADA S3 prohibited except narrow permitted inhaled thresholds | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/other-beta-2-agonists-salbutamol-formoterol-salmeterol-terbutaline.md | html=https://readofflabel.com/compound/other-beta-2-agonists-salbutamol-formoterol-salmeterol-terbutaline/ - Meldonium | grade=C- (4.3/10) | evidence=4/10 | benefit=3.5/10 | safety=5/10 | category=Metabolic Health | class=Prescription | legal_status=Rx in parts of Eastern Europe; not FDA-approved; WADA S4 prohibited | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/meldonium.md | html=https://readofflabel.com/compound/meldonium/ - PCSK9 base editing (VERVE-102) | grade=C- (4.0/10) | evidence=3/10 | benefit=8/10 | safety=3.5/10 | category=Metabolic Health | class=Supplement | legal_status=Investigational (Phase 1b/2; not approved) | last_reviewed=2026-07-11 | md=https://readofflabel.com/compound/pcsk9-base-editing-verve-102.md | html=https://readofflabel.com/compound/pcsk9-base-editing-verve-102/ - Trimetazidine | grade=D+ (3.9/10) | evidence=3/10 | benefit=3.5/10 | safety=5/10 | category=Metabolic Health | class=Prescription | legal_status=Rx in some countries for angina; not FDA-approved; WADA S4 prohibited | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/trimetazidine.md | html=https://readofflabel.com/compound/trimetazidine/ - Tesofensine | grade=D+ (3.7/10) | evidence=3/10 | benefit=6.5/10 | safety=3.5/10 | category=Metabolic Health | class=Prescription | legal_status=Investigational in multiple jurisdictions; not approved | last_reviewed=2026-07-11 | md=https://readofflabel.com/compound/tesofensine.md | html=https://readofflabel.com/compound/tesofensine/ - AICAR | grade=D (3.3/10) | evidence=2/10 | benefit=8/10 | safety=3/10 | category=Metabolic Health | class=Supplement | legal_status=Research/clinical-research compound; WADA S4 prohibited | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/aicar.md | html=https://readofflabel.com/compound/aicar/ - SLU-PP-332 | grade=D (3.3/10) | evidence=2/10 | benefit=5/10 | safety=4/10 | category=Metabolic Health | class=Research chemical | legal_status=Not approved; research chemical / gray-market peptide-vendor sales; no approved human indication | last_reviewed=2026-06-07 | md=https://readofflabel.com/compound/slu-pp-332.md | html=https://readofflabel.com/compound/slu-pp-332/ - SR9009 / SR9011 | grade=D (2.9/10) | evidence=2/10 | benefit=5/10 | safety=3/10 | category=Metabolic Health | class=Research chemical | legal_status=Research chemical; WADA S4 prohibited | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/sr9009-sr9011.md | html=https://readofflabel.com/compound/sr9009-sr9011/ - Diuretic weight-cutting / masking agents | grade=D (2.9/10) | evidence=3/10 | benefit=5/10 | safety=2/10 | category=Metabolic Health | class=Prescription | legal_status=Rx/OTC/status varies; WADA S5 prohibited at all times except listed exceptions | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/diuretic-weight-cutting-masking-agents.md | html=https://readofflabel.com/compound/diuretic-weight-cutting-masking-agents/ - Insulin / insulin-mimetics for performance use | grade=D- (2.6/10) | evidence=3/10 | benefit=8/10 | safety=0/10 | category=Metabolic Health | class=Anabolic | legal_status=Rx; WADA S4 prohibited | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/insulin-insulin-mimetics-for-performance-use.md | html=https://readofflabel.com/compound/insulin-insulin-mimetics-for-performance-use/ ## Mitochondria & Cellular Energy (10) - CoQ10 (ubiquinone/ubiquinol) | grade=A+ (8.2/10) | evidence=8/10 | benefit=6.5/10 | safety=9/10 | category=Mitochondria & Cellular Energy | class=Supplement | legal_status=OTC | last_reviewed=2026-07-01 | md=https://readofflabel.com/compound/coq10-ubiquinone-ubiquinol.md | html=https://readofflabel.com/compound/coq10-ubiquinone-ubiquinol/ - Urolithin A | grade=B+ (7.3/10) | evidence=6/10 | benefit=6.5/10 | safety=9/10 | category=Mitochondria & Cellular Energy | class=Supplement | legal_status=OTC (Mitopure/Timeline) | last_reviewed=2026-07-01 | md=https://readofflabel.com/compound/urolithin-a.md | html=https://readofflabel.com/compound/urolithin-a/ - Red light therapy / photobiomodulation (PBM) | grade=B+ (7.1/10) | evidence=6/10 | benefit=5/10 | safety=9/10 | category=Mitochondria & Cellular Energy | class=Protocol | legal_status=OTC (devices) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/red-light-therapy-photobiomodulation-pbm.md | html=https://readofflabel.com/compound/red-light-therapy-photobiomodulation-pbm/ - SS-31 (elamipretide) | grade=B+ (7.1/10) | evidence=6/10 | benefit=5/10 | safety=9/10 | category=Mitochondria & Cellular Energy | class=Peptide | legal_status=Rx in US — FDA accelerated approval Sept 2025 as FORZINITY (elamipretide) for Barth syndrome (first approved mitochondria-targeted therapeutic); off-label/investigational for mitochondrial-energy and longevity uses | last_reviewed=2026-07-27 | md=https://readofflabel.com/compound/ss-31-elamipretide.md | html=https://readofflabel.com/compound/ss-31-elamipretide/ - Alpha-lipoic acid (ALA) | grade=B+ (7.1/10) | evidence=6/10 | benefit=5/10 | safety=9/10 | category=Mitochondria & Cellular Energy | class=Prescription | legal_status=OTC | last_reviewed=2026-07-01 | md=https://readofflabel.com/compound/alpha-lipoic-acid-ala.md | html=https://readofflabel.com/compound/alpha-lipoic-acid-ala/ - Hydrogen water / molecular hydrogen (H2) | grade=B (6.8/10) | evidence=6/10 | benefit=3.5/10 | safety=9/10 | category=Mitochondria & Cellular Energy | class=Supplement | legal_status=OTC (tablets, water generators, inhalation devices) | last_reviewed=2026-07-01 | md=https://readofflabel.com/compound/hydrogen-water-molecular-hydrogen-h2.md | html=https://readofflabel.com/compound/hydrogen-water-molecular-hydrogen-h2/ - Ergothioneine | grade=B (6.4/10) | evidence=4.5/10 | benefit=5/10 | safety=9/10 | category=Mitochondria & Cellular Energy | class=Herbal | legal_status=OTC | last_reviewed=2026-07-01 | md=https://readofflabel.com/compound/ergothioneine.md | html=https://readofflabel.com/compound/ergothioneine/ - Pyrroloquinoline quinone (PQQ) | grade=B- (6.2/10) | evidence=4.5/10 | benefit=3.5/10 | safety=9/10 | category=Mitochondria & Cellular Energy | class=Prescription | legal_status=OTC | last_reviewed=2026-07-01 | md=https://readofflabel.com/compound/pyrroloquinoline-quinone-pqq.md | html=https://readofflabel.com/compound/pyrroloquinoline-quinone-pqq/ - Methylene blue | grade=C (4.9/10) | evidence=6/10 | benefit=5/10 | safety=3.5/10 | category=Mitochondria & Cellular Energy | class=Prescription | legal_status=Rx (methemoglobinemia, cyanide poisoning, ifosfamide encephalopathy); USP/pharma grade is marketed OTC in many jurisdictions as "longevity" supplement; product-grade verification varies | last_reviewed=2026-07-11 | md=https://readofflabel.com/compound/methylene-blue.md | html=https://readofflabel.com/compound/methylene-blue/ - BAM15 | grade=D (2.9/10) | evidence=2/10 | benefit=5/10 | safety=3/10 | category=Mitochondria & Cellular Energy | class=Research chemical | legal_status=Research chemical; WADA S4 prohibited | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/bam15.md | html=https://readofflabel.com/compound/bam15/ ## Mood, Anxiety & Stress (34) - TMS (transcranial magnetic stimulation) | grade=A+ (8.4/10) | evidence=8/10 | benefit=8/10 | safety=9/10 | category=Mood, Anxiety & Stress | class=Supplement | legal_status=In-office; Rx/procedure (covered by many insurers for TRD) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/tms-transcranial-magnetic-stimulation.md | html=https://readofflabel.com/compound/tms-transcranial-magnetic-stimulation/ - Meditation / mindfulness | grade=A+ (8.2/10) | evidence=8/10 | benefit=6.5/10 | safety=9/10 | category=Mood, Anxiety & Stress | class=Protocol | legal_status=N/A | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/meditation-mindfulness.md | html=https://readofflabel.com/compound/meditation-mindfulness/ - Propranolol | grade=A- (7.7/10) | evidence=8/10 | benefit=3.5/10 | safety=9/10 | category=Mood, Anxiety & Stress | class=Prescription | legal_status=Rx | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/propranolol.md | html=https://readofflabel.com/compound/propranolol/ - Saffron extract (Crocus sativus) | grade=B+ (7.1/10) | evidence=6/10 | benefit=5/10 | safety=9/10 | category=Mood, Anxiety & Stress | class=Herbal | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/saffron-extract-crocus-sativus.md | html=https://readofflabel.com/compound/saffron-extract-crocus-sativus/ - Inositol (myo-inositol / D-chiro-inositol) | grade=B+ (7.1/10) | evidence=6/10 | benefit=5/10 | safety=9/10 | category=Mood, Anxiety & Stress | class=Supplement | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/inositol-myo-inositol-d-chiro-inositol.md | html=https://readofflabel.com/compound/inositol-myo-inositol-d-chiro-inositol/ - Buspirone | grade=B+ (7.1/10) | evidence=6/10 | benefit=5/10 | safety=9/10 | category=Mood, Anxiety & Stress | class=Prescription | legal_status=Rx | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/buspirone.md | html=https://readofflabel.com/compound/buspirone/ - Breathwork (structured breathing) | grade=B (6.8/10) | evidence=6/10 | benefit=3.5/10 | safety=9/10 | category=Mood, Anxiety & Stress | class=Protocol | legal_status=N/A | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/breathwork-structured-breathing.md | html=https://readofflabel.com/compound/breathwork-structured-breathing/ - SNRIs (venlafaxine / duloxetine) | grade=B (6.8/10) | evidence=8/10 | benefit=8/10 | safety=5/10 | category=Mood, Anxiety & Stress | class=Prescription | legal_status=Rx | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/snris-venlafaxine-duloxetine.md | html=https://readofflabel.com/compound/snris-venlafaxine-duloxetine/ - Bupropion (Wellbutrin) | grade=B (6.8/10) | evidence=8/10 | benefit=8/10 | safety=5/10 | category=Mood, Anxiety & Stress | class=Prescription | legal_status=Rx | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/bupropion-wellbutrin.md | html=https://readofflabel.com/compound/bupropion-wellbutrin/ - Electroconvulsive therapy (ECT) | grade=B (6.8/10) | evidence=8/10 | benefit=8/10 | safety=5/10 | category=Mood, Anxiety & Stress | class=Supplement | legal_status=In-hospital procedure under general anesthesia with informed consent; covered by most insurers for TRD/catatonia/psychotic depression | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/electroconvulsive-therapy-ect.md | html=https://readofflabel.com/compound/electroconvulsive-therapy-ect/ - Dextromethorphan-bupropion (Auvelity / AXS-05) | grade=B (6.8/10) | evidence=8/10 | benefit=8/10 | safety=5/10 | category=Mood, Anxiety & Stress | class=Prescription | legal_status=Rx | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/dextromethorphan-bupropion-auvelity-axs-05.md | html=https://readofflabel.com/compound/dextromethorphan-bupropion-auvelity-axs-05/ - Zuranolone (Zurzuvae) | grade=B (6.8/10) | evidence=8/10 | benefit=8/10 | safety=5/10 | category=Mood, Anxiety & Stress | class=Hormone | legal_status=Rx (Schedule IV; FDA-approved PPD only) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/zuranolone-zurzuvae.md | html=https://readofflabel.com/compound/zuranolone-zurzuvae/ - Xanomeline-trospium (KarXT / Cobenfy) | grade=B (6.8/10) | evidence=8/10 | benefit=8/10 | safety=5/10 | category=Mood, Anxiety & Stress | class=Prescription | legal_status=Rx (FDA-approved Sept 2024 for schizophrenia) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/xanomeline-trospium-karxt-cobenfy.md | html=https://readofflabel.com/compound/xanomeline-trospium-karxt-cobenfy/ - Psilocybin | grade=B (6.6/10) | evidence=8/10 | benefit=6.5/10 | safety=5/10 | category=Mood, Anxiety & Stress | class=Research chemical | legal_status=Schedule I US (DEA); legal in regulated contexts: Oregon (Measure 109), Colorado (Prop 122), decriminalized in some cities; legal for therapy in Australia | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/psilocybin.md | html=https://readofflabel.com/compound/psilocybin/ - SSRIs (sertraline / escitalopram / fluoxetine) | grade=B (6.6/10) | evidence=8/10 | benefit=6.5/10 | safety=5/10 | category=Mood, Anxiety & Stress | class=Prescription | legal_status=Rx | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/ssris-sertraline-escitalopram-fluoxetine.md | html=https://readofflabel.com/compound/ssris-sertraline-escitalopram-fluoxetine/ - Lumateperone (Caplyta) | grade=B (6.6/10) | evidence=8/10 | benefit=6.5/10 | safety=5/10 | category=Mood, Anxiety & Stress | class=Prescription | legal_status=Rx (FDA-approved: schizophrenia, bipolar depression, MDD adjunct) | last_reviewed=2026-06-07 | md=https://readofflabel.com/compound/lumateperone-caplyta.md | html=https://readofflabel.com/compound/lumateperone-caplyta/ - St. John's wort (Hypericum perforatum) | grade=B (6.4/10) | evidence=8/10 | benefit=5/10 | safety=5/10 | category=Mood, Anxiety & Stress | class=Prescription | legal_status=OTC (US); Rx in Germany (standardized) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/st-john-s-wort-hypericum-perforatum.md | html=https://readofflabel.com/compound/st-john-s-wort-hypericum-perforatum/ - Gabapentin / pregabalin | grade=B (6.4/10) | evidence=8/10 | benefit=5/10 | safety=5/10 | category=Mood, Anxiety & Stress | class=Prescription | legal_status=Rx (pregabalin Schedule V US) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/gabapentin-pregabalin.md | html=https://readofflabel.com/compound/gabapentin-pregabalin/ - Ashwagandha (Withania somnifera) | grade=B- (6.3/10) | evidence=6/10 | benefit=5/10 | safety=7/10 | category=Mood, Anxiety & Stress | class=Herbal | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/ashwagandha-withania-somnifera.md | html=https://readofflabel.com/compound/ashwagandha-withania-somnifera/ - SAM-e (S-adenosylmethionine) | grade=B- (6.3/10) | evidence=6/10 | benefit=5/10 | safety=7/10 | category=Mood, Anxiety & Stress | class=Prescription | legal_status=Rx in EU; OTC in US | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/sam-e-s-adenosylmethionine.md | html=https://readofflabel.com/compound/sam-e-s-adenosylmethionine/ - Lithium (microdose vs therapeutic) | grade=B- (6.1/10) | evidence=10/10 | benefit=5/10 | safety=2/10 | category=Mood, Anxiety & Stress | class=Mineral | legal_status=Rx (lithium carbonate); OTC (lithium orotate microdoses) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/lithium-microdose-vs-therapeutic.md | html=https://readofflabel.com/compound/lithium-microdose-vs-therapeutic/ - Ketamine | grade=B- (6.0/10) | evidence=8/10 | benefit=6.5/10 | safety=3.5/10 | category=Mood, Anxiety & Stress | class=Prescription | legal_status=Rx (Schedule III US); esketamine REMS program | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/ketamine.md | html=https://readofflabel.com/compound/ketamine/ - Olanzapine + samidorphan (Lybalvi) | grade=B- (6.0/10) | evidence=8/10 | benefit=6.5/10 | safety=3.5/10 | category=Mood, Anxiety & Stress | class=Prescription | legal_status=Rx (FDA-approved: schizophrenia, bipolar I) | last_reviewed=2026-06-07 | md=https://readofflabel.com/compound/olanzapine-samidorphan-lybalvi.md | html=https://readofflabel.com/compound/olanzapine-samidorphan-lybalvi/ - LSD (lysergic acid diethylamide) | grade=C+ (5.7/10) | evidence=6/10 | benefit=6.5/10 | safety=5/10 | category=Mood, Anxiety & Stress | class=Research chemical | legal_status=Schedule I US; Class A UK | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/lsd-lysergic-acid-diethylamide.md | html=https://readofflabel.com/compound/lsd-lysergic-acid-diethylamide/ - Kava (Piper methysticum) | grade=C+ (5.5/10) | evidence=6/10 | benefit=5/10 | safety=5/10 | category=Mood, Anxiety & Stress | class=Prescription | legal_status=Variable by country — OTC US; heavily regulated/banned in UK, Germany, Australia, Canada (though bans partially lifted) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/kava-piper-methysticum.md | html=https://readofflabel.com/compound/kava-piper-methysticum/ - Other beta-blockers (atenolol / metoprolol / nadolol) | grade=C+ (5.5/10) | evidence=6/10 | benefit=5/10 | safety=5/10 | category=Mood, Anxiety & Stress | class=Prescription | legal_status=Rx; WADA P1 prohibited in specified sports | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/other-beta-blockers-atenolol-metoprolol-nadolol.md | html=https://readofflabel.com/compound/other-beta-blockers-atenolol-metoprolol-nadolol/ - GABA (gamma-aminobutyric acid) | grade=C+ (5.3/10) | evidence=3/10 | benefit=2/10 | safety=9/10 | category=Mood, Anxiety & Stress | class=Prescription | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/gaba-gamma-aminobutyric-acid.md | html=https://readofflabel.com/compound/gaba-gamma-aminobutyric-acid/ - Selegiline (L-deprenyl) | grade=C+ (5.2/10) | evidence=6/10 | benefit=3.5/10 | safety=5/10 | category=Mood, Anxiety & Stress | class=Prescription | legal_status=Rx | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/selegiline-l-deprenyl.md | html=https://readofflabel.com/compound/selegiline-l-deprenyl/ - MDMA (3,4-methylenedioxymethamphetamine) | grade=C (5.1/10) | evidence=6/10 | benefit=6.5/10 | safety=3.5/10 | category=Mood, Anxiety & Stress | class=Research chemical | legal_status=Schedule I US; expanded access in Australia for PTSD | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/mdma-3-4-methylenedioxymethamphetamine.md | html=https://readofflabel.com/compound/mdma-3-4-methylenedioxymethamphetamine/ - Ayahuasca / DMT | grade=C- (4.4/10) | evidence=4.5/10 | benefit=6.5/10 | safety=3.5/10 | category=Mood, Anxiety & Stress | class=Research chemical | legal_status=DMT Schedule I US; ayahuasca religious exemption (UDV, Santo Daime) in US | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/ayahuasca-dmt.md | html=https://readofflabel.com/compound/ayahuasca-dmt/ - Tianeptine | grade=C- (4.3/10) | evidence=6/10 | benefit=5/10 | safety=2/10 | category=Mood, Anxiety & Stress | class=Prescription | legal_status=Rx in EU/Asia; unscheduled US (FDA warnings; state-level scheduling accelerating) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/tianeptine.md | html=https://readofflabel.com/compound/tianeptine/ - Ibogaine | grade=C- (4.0/10) | evidence=4.5/10 | benefit=8/10 | safety=2/10 | category=Mood, Anxiety & Stress | class=Research chemical | legal_status=Schedule I US; legal in Mexico, Costa Rica, Portugal, some other countries; Gabon/Cameroon sacrament | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/ibogaine.md | html=https://readofflabel.com/compound/ibogaine/ - 5-HTP (5-hydroxytryptophan) | grade=D+ (3.9/10) | evidence=3/10 | benefit=3.5/10 | safety=5/10 | category=Mood, Anxiety & Stress | class=Supplement | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/5-htp-5-hydroxytryptophan.md | html=https://readofflabel.com/compound/5-htp-5-hydroxytryptophan/ - Phenibut (β-phenyl-GABA) | grade=D (2.9/10) | evidence=3/10 | benefit=5/10 | safety=2/10 | category=Mood, Anxiety & Stress | class=Research chemical | legal_status=Russia (Rx — Anvifen, Noofen); not FDA-approved in US; not a lawful dietary supplement ingredient; sold as research chemical; UK/Australia controlled | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/phenibut-phenyl-gaba.md | html=https://readofflabel.com/compound/phenibut-phenyl-gaba/ ## Muscle & Strength (44) - Resistance training | grade=S (9.3/10) | evidence=10/10 | benefit=8/10 | safety=9/10 | category=Muscle & Strength | class=Protocol | legal_status=N/A | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/resistance-training.md | html=https://readofflabel.com/compound/resistance-training/ - Beta-alanine | grade=A+ (8.2/10) | evidence=8/10 | benefit=6.5/10 | safety=9/10 | category=Muscle & Strength | class=Supplement | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/beta-alanine.md | html=https://readofflabel.com/compound/beta-alanine/ - Blood flow restriction (BFR) training | grade=A- (7.6/10) | evidence=8/10 | benefit=8/10 | safety=7/10 | category=Muscle & Strength | class=Protocol | legal_status=OTC (devices) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/blood-flow-restriction-bfr-training.md | html=https://readofflabel.com/compound/blood-flow-restriction-bfr-training/ - Testosterone (TRT / supraphysiological) | grade=B (6.8/10) | evidence=8/10 | benefit=8/10 | safety=5/10 | category=Muscle & Strength | class=Anabolic | legal_status=Rx for hypogonadism (Schedule III US as anabolic steroid); illicit supraphysiological use illegal | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/testosterone-trt-supraphysiological.md | html=https://readofflabel.com/compound/testosterone-trt-supraphysiological/ - Sodium bicarbonate | grade=B (6.6/10) | evidence=8/10 | benefit=6.5/10 | safety=5/10 | category=Muscle & Strength | class=Supplement | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/sodium-bicarbonate.md | html=https://readofflabel.com/compound/sodium-bicarbonate/ - Anavar (oxandrolone) | grade=B (6.6/10) | evidence=8/10 | benefit=6.5/10 | safety=5/10 | category=Muscle & Strength | class=Anabolic | legal_status=Schedule III US; Rx but rare; expensive genuine product — most illicit is counterfeit | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/anavar-oxandrolone.md | html=https://readofflabel.com/compound/anavar-oxandrolone/ - Tesamorelin | grade=B- (5.8/10) | evidence=8/10 | benefit=5/10 | safety=3.5/10 | category=Muscle & Strength | class=Anabolic | legal_status=Rx (Egrifta/Egrifta SV) for HIV lipodystrophy; off-label for visceral fat reduction | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/tesamorelin.md | html=https://readofflabel.com/compound/tesamorelin/ - Dianabol (methandrostenolone / methandienone) | grade=C+ (5.6/10) | evidence=8/10 | benefit=8/10 | safety=2/10 | category=Muscle & Strength | class=Anabolic | legal_status=Schedule III US; banned sport; Rx history discontinued | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/dianabol-methandrostenolone-methandienone.md | html=https://readofflabel.com/compound/dianabol-methandrostenolone-methandienone/ - Deca-Durabolin (nandrolone decanoate) | grade=C+ (5.6/10) | evidence=8/10 | benefit=8/10 | safety=2/10 | category=Muscle & Strength | class=Anabolic | legal_status=Schedule III US; Rx for anemia/wasting in some countries; banned sport | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/deca-durabolin-nandrolone-decanoate.md | html=https://readofflabel.com/compound/deca-durabolin-nandrolone-decanoate/ - Nandrolone (phenylpropionate / other esters) | grade=C+ (5.6/10) | evidence=8/10 | benefit=8/10 | safety=2/10 | category=Muscle & Strength | class=Anabolic | legal_status=Schedule III US; banned sport | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/nandrolone-phenylpropionate-other-esters.md | html=https://readofflabel.com/compound/nandrolone-phenylpropionate-other-esters/ - Sermorelin | grade=C+ (5.6/10) | evidence=4.5/10 | benefit=5/10 | safety=7/10 | category=Muscle & Strength | class=Anabolic | legal_status=Originally FDA-approved (Geref, Serono 1997 for pediatric GHD diagnosis); commercially withdrawn 2008 (Serono cited economic — not safety — reasons); currently legally compoundable from 503A/503B pharmacies in the US — SURVIVED the April 22 2026 FDA 503A Category 2 actions that removed 12 other peptides including dihexa | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/sermorelin.md | html=https://readofflabel.com/compound/sermorelin/ - Other WADA-listed anabolic androgenic steroids (AAS long tail) | grade=C+ (5.6/10) | evidence=8/10 | benefit=8/10 | safety=2/10 | category=Muscle & Strength | class=Anabolic | legal_status=Controlled/illegal without prescription in many countries; WADA S1 prohibited at all times | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/other-wada-listed-anabolic-androgenic-steroids-aas-long-tail.md | html=https://readofflabel.com/compound/other-wada-listed-anabolic-androgenic-steroids-aas-long-tail/ - EPO / erythropoiesis-stimulating agents (ESAs) | grade=C+ (5.6/10) | evidence=8/10 | benefit=8/10 | safety=2/10 | category=Muscle & Strength | class=Prescription | legal_status=Rx for anemia indications; WADA S2 prohibited at all times | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/epo-erythropoiesis-stimulating-agents-esas.md | html=https://readofflabel.com/compound/epo-erythropoiesis-stimulating-agents-esas/ - Primobolan (methenolone) | grade=C+ (5.5/10) | evidence=6/10 | benefit=5/10 | safety=5/10 | category=Muscle & Strength | class=Anabolic | legal_status=Schedule III US; Rx history discontinued; banned sport | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/primobolan-methenolone.md | html=https://readofflabel.com/compound/primobolan-methenolone/ - Ostarine (MK-2866 / enobosarm) | grade=C+ (5.5/10) | evidence=6/10 | benefit=5/10 | safety=5/10 | category=Muscle & Strength | class=Anabolic | legal_status=NOT FDA-approved; sold as 'research chemical' (gray market); repeated SARMs Control Act bills (2018/2019/2025) have not passed — still not federally scheduled; banned sport (WADA) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/ostarine-mk-2866-enobosarm.md | html=https://readofflabel.com/compound/ostarine-mk-2866-enobosarm/ - Winstrol (stanozolol) | grade=C+ (5.4/10) | evidence=8/10 | benefit=6.5/10 | safety=2/10 | category=Muscle & Strength | class=Anabolic | legal_status=Schedule III US; Rx history discontinued in most countries; banned sport (Ben Johnson 1988) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/winstrol-stanozolol.md | html=https://readofflabel.com/compound/winstrol-stanozolol/ - Boldenone (Equipoise) | grade=C+ (5.3/10) | evidence=6/10 | benefit=8/10 | safety=3.5/10 | category=Muscle & Strength | class=Anabolic | legal_status=Schedule III US (human use); veterinary only officially; banned sport | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/boldenone-equipoise.md | html=https://readofflabel.com/compound/boldenone-equipoise/ - Trenbolone | grade=C (5.1/10) | evidence=8/10 | benefit=10/10 | safety=0/10 | category=Muscle & Strength | class=Anabolic | legal_status=Schedule III US (when diverted for human use); banned sport | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/trenbolone.md | html=https://readofflabel.com/compound/trenbolone/ - Anadrol (oxymetholone) | grade=C (5.1/10) | evidence=8/10 | benefit=10/10 | safety=0/10 | category=Muscle & Strength | class=Anabolic | legal_status=Schedule III US; Rx (anaemia) as Anadrol-50; banned sport | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/anadrol-oxymetholone.md | html=https://readofflabel.com/compound/anadrol-oxymetholone/ - Masteron (drostanolone) | grade=C (5.1/10) | evidence=6/10 | benefit=6.5/10 | safety=3.5/10 | category=Muscle & Strength | class=Anabolic | legal_status=Schedule III US; banned sport | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/masteron-drostanolone.md | html=https://readofflabel.com/compound/masteron-drostanolone/ - Ipamorelin | grade=C (4.9/10) | evidence=3/10 | benefit=5/10 | safety=7/10 | category=Muscle & Strength | class=Anabolic | legal_status=Research peptide; not FDA-approved; banned sport | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/ipamorelin.md | html=https://readofflabel.com/compound/ipamorelin/ - MK-677 (ibutamoren) | grade=C (4.9/10) | evidence=6/10 | benefit=5/10 | safety=3.5/10 | category=Muscle & Strength | class=Anabolic | legal_status=Research chemical (not scheduled); banned sport | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/mk-677-ibutamoren.md | html=https://readofflabel.com/compound/mk-677-ibutamoren/ - HIF stabilizers / prolyl-hydroxylase inhibitors (roxadustat / daprodustat / vadadustat) | grade=C (4.9/10) | evidence=6/10 | benefit=5/10 | safety=3.5/10 | category=Muscle & Strength | class=Prescription | legal_status=Rx/investigational depending country and agent; WADA S2 prohibited at all times | last_reviewed=2026-07-11 | md=https://readofflabel.com/compound/hif-stabilizers-prolyl-hydroxylase-inhibitors-roxadustat-daprodustat-vadadustat.md | html=https://readofflabel.com/compound/hif-stabilizers-prolyl-hydroxylase-inhibitors-roxadustat-daprodustat-vadadustat/ - Myostatin / activin-pathway inhibitors (non-bimagrumab) | grade=C (4.9/10) | evidence=6/10 | benefit=5/10 | safety=3.5/10 | category=Muscle & Strength | class=Anabolic | legal_status=Investigational/Rx biologics depending program; WADA S4 prohibited | last_reviewed=2026-07-16 | md=https://readofflabel.com/compound/myostatin-activin-pathway-inhibitors-non-bimagrumab.md | html=https://readofflabel.com/compound/myostatin-activin-pathway-inhibitors-non-bimagrumab/ - Ligandrol (LGD-4033) | grade=C (4.8/10) | evidence=4.5/10 | benefit=5/10 | safety=5/10 | category=Muscle & Strength | class=Anabolic | legal_status=NOT FDA-approved; gray market; banned sport (WADA) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/ligandrol-lgd-4033.md | html=https://readofflabel.com/compound/ligandrol-lgd-4033/ - Artificial oxygen carriers / blood doping methods | grade=C (4.7/10) | evidence=6/10 | benefit=8/10 | safety=2/10 | category=Muscle & Strength | class=Supplement | legal_status=Medical/research/procedure context only; WADA M1 prohibited method | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/artificial-oxygen-carriers-blood-doping-methods.md | html=https://readofflabel.com/compound/artificial-oxygen-carriers-blood-doping-methods/ - Cardarine (GW501516) | grade=C- (4.2/10) | evidence=6/10 | benefit=10/10 | safety=0/10 | category=Muscle & Strength | class=Anabolic | legal_status=NOT FDA-approved; gray market; WADA banned with special cancer warning to athletes | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/cardarine-gw501516.md | html=https://readofflabel.com/compound/cardarine-gw501516/ - HGH (recombinant human growth hormone) | grade=C- (4.2/10) | evidence=4.5/10 | benefit=5/10 | safety=3.5/10 | category=Muscle & Strength | class=Anabolic | legal_status=Rx for approved indications; off-label/illicit for anti-aging/performance illegal in US (Anti-Drug Abuse Act of 1988 specifically criminalizes non-indicated HGH) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/hgh-recombinant-human-growth-hormone.md | html=https://readofflabel.com/compound/hgh-recombinant-human-growth-hormone/ - CJC-1295 (with/without DAC) | grade=C- (4.1/10) | evidence=3/10 | benefit=5/10 | safety=5/10 | category=Muscle & Strength | class=Anabolic | legal_status=Research peptide; not FDA-approved; banned sport | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/cjc-1295-with-without-dac.md | html=https://readofflabel.com/compound/cjc-1295-with-without-dac/ - GHRP-2 / GHRP-6 | grade=C- (4.1/10) | evidence=3/10 | benefit=5/10 | safety=5/10 | category=Muscle & Strength | class=Anabolic | legal_status=Research peptide; banned sport | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/ghrp-2-ghrp-6.md | html=https://readofflabel.com/compound/ghrp-2-ghrp-6/ - Mesterolone (Proviron) | grade=D+ (3.9/10) | evidence=3/10 | benefit=3.5/10 | safety=5/10 | category=Muscle & Strength | class=Anabolic | legal_status=NOT FDA-approved in US (never marketed); Schedule III controlled substance under the Anabolic Steroid Control Act; Rx in EU/UK/Asia/Australia/Latin America (Schering/Bayer Proviron); WADA Prohibited List S1 (anabolic agents) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/mesterolone-proviron.md | html=https://readofflabel.com/compound/mesterolone-proviron/ - Other GH secretagogues / GHRPs | grade=D+ (3.9/10) | evidence=3/10 | benefit=3.5/10 | safety=5/10 | category=Muscle & Strength | class=Anabolic | legal_status=Some approved for narrow indications/diagnostics; many research chemicals; WADA S2 prohibited | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/other-gh-secretagogues-ghrps.md | html=https://readofflabel.com/compound/other-gh-secretagogues-ghrps/ - RAD-140 (testolone) | grade=D+ (3.7/10) | evidence=3/10 | benefit=6.5/10 | safety=3.5/10 | category=Muscle & Strength | class=Anabolic | legal_status=NOT FDA-approved; gray market; banned sport (WADA) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/rad-140-testolone.md | html=https://readofflabel.com/compound/rad-140-testolone/ - ACP-105 | grade=D (3.3/10) | evidence=2/10 | benefit=5/10 | safety=4/10 | category=Muscle & Strength | class=Anabolic | legal_status=NOT FDA-approved; gray market; banned sport | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/acp-105.md | html=https://readofflabel.com/compound/acp-105/ - LGD-3303 | grade=D (3.3/10) | evidence=2/10 | benefit=5/10 | safety=4/10 | category=Muscle & Strength | class=Anabolic | legal_status=NOT FDA-approved; gray market; banned sport | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/lgd-3303.md | html=https://readofflabel.com/compound/lgd-3303/ - Long-acting GH analogs and GH fragments | grade=D (3.3/10) | evidence=3/10 | benefit=3.5/10 | safety=3.5/10 | category=Muscle & Strength | class=Research chemical | legal_status=Rx for approved GH-deficiency indications or research chemical; WADA S2 prohibited | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/long-acting-gh-analogs-and-gh-fragments.md | html=https://readofflabel.com/compound/long-acting-gh-analogs-and-gh-fragments/ - Ryanodine stabilizers / fast skeletal muscle troponin activators | grade=D (3.1/10) | evidence=2.5/10 | benefit=5/10 | safety=3/10 | category=Muscle & Strength | class=Supplement | legal_status=Investigational/not approved for performance; WADA S0 prohibited | last_reviewed=2026-07-11 | md=https://readofflabel.com/compound/ryanodine-stabilizers-fast-skeletal-muscle-troponin-activators.md | html=https://readofflabel.com/compound/ryanodine-stabilizers-fast-skeletal-muscle-troponin-activators/ - YK-11 | grade=D (2.9/10) | evidence=2/10 | benefit=5/10 | safety=3/10 | category=Muscle & Strength | class=Anabolic | legal_status=NOT FDA-approved; gray market; banned sport | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/yk-11.md | html=https://readofflabel.com/compound/yk-11/ - S-23 | grade=D (2.9/10) | evidence=2/10 | benefit=5/10 | safety=3/10 | category=Muscle & Strength | class=Anabolic | legal_status=NOT FDA-approved; gray market; banned sport | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/s-23.md | html=https://readofflabel.com/compound/s-23/ - IGF-1 LR3 (long R3 insulin-like growth factor-1) | grade=D (2.9/10) | evidence=3/10 | benefit=5/10 | safety=2/10 | category=Muscle & Strength | class=Anabolic | legal_status=Research chem (not approved); banned sport | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/igf-1-lr3-long-r3-insulin-like-growth-factor-1.md | html=https://readofflabel.com/compound/igf-1-lr3-long-r3-insulin-like-growth-factor-1/ - Andarine (S-4) | grade=D (2.9/10) | evidence=2/10 | benefit=5/10 | safety=3/10 | category=Muscle & Strength | class=Anabolic | legal_status=Not FDA-approved; research chemical/gray market; WADA S1 prohibited | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/andarine-s-4.md | html=https://readofflabel.com/compound/andarine-s-4/ - Veterinary growth promoters (ractopamine / zilpaterol / zeranol) | grade=D (2.9/10) | evidence=3/10 | benefit=5/10 | safety=2/10 | category=Muscle & Strength | class=Prescription | legal_status=Veterinary/feed-additive use varies by country; not approved for human performance; WADA S1 prohibited | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/veterinary-growth-promoters-ractopamine-zilpaterol-zeranol.md | html=https://readofflabel.com/compound/veterinary-growth-promoters-ractopamine-zilpaterol-zeranol/ - Gene and cell doping (performance-enhancing) | grade=F (1.7/10) | evidence=2/10 | benefit=5/10 | safety=0/10 | category=Muscle & Strength | class=Supplement | legal_status=Experimental medical/research context only; WADA M3 prohibited method | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/gene-and-cell-doping-performance-enhancing.md | html=https://readofflabel.com/compound/gene-and-cell-doping-performance-enhancing/ - Growth-factor doping agents (FGF / HGF / PDGF / VEGF / MGF) | grade=F (1.7/10) | evidence=2/10 | benefit=5/10 | safety=0/10 | category=Muscle & Strength | class=Supplement | legal_status=Research/biologic context; WADA S2 prohibited | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/growth-factor-doping-agents-fgf-hgf-pdgf-vegf-mgf.md | html=https://readofflabel.com/compound/growth-factor-doping-agents-fgf-hgf-pdgf-vegf-mgf/ ## Sleep & Recovery (38) - Suzetrigine (Journavx / VX-548) | grade=A+ (8.2/10) | evidence=8/10 | benefit=6.5/10 | safety=9/10 | category=Sleep & Recovery | class=Prescription | legal_status=Rx (FDA-approved Jan 2025 for moderate-to-severe acute pain) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/suzetrigine-journavx-vx-548.md | html=https://readofflabel.com/compound/suzetrigine-journavx-vx-548/ - Melatonin | grade=A- (7.7/10) | evidence=8/10 | benefit=3.5/10 | safety=9/10 | category=Sleep & Recovery | class=Hormone | legal_status=OTC (US; Rx in UK/EU/Canada where 2mg Circadin is a prescription) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/melatonin.md | html=https://readofflabel.com/compound/melatonin/ - Sunlight / circadian light exposure | grade=A- (7.6/10) | evidence=8/10 | benefit=8/10 | safety=7/10 | category=Sleep & Recovery | class=Protocol | legal_status=N/A | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/sunlight-circadian-light-exposure.md | html=https://readofflabel.com/compound/sunlight-circadian-light-exposure/ - Cognitive behavioral therapy for insomnia (CBT-I) | grade=A- (7.6/10) | evidence=8/10 | benefit=8/10 | safety=7/10 | category=Sleep & Recovery | class=Protocol | legal_status=N/A (behavioral therapy; digital programs and clinician-guided protocols available) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/cognitive-behavioral-therapy-for-insomnia-cbt-i.md | html=https://readofflabel.com/compound/cognitive-behavioral-therapy-for-insomnia-cbt-i/ - DORAs (suvorexant / lemborexant / daridorexant) | grade=A- (7.6/10) | evidence=8/10 | benefit=8/10 | safety=7/10 | category=Sleep & Recovery | class=Prescription | legal_status=Rx (Schedule IV US) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/doras-suvorexant-lemborexant-daridorexant.md | html=https://readofflabel.com/compound/doras-suvorexant-lemborexant-daridorexant/ - HMB (β-hydroxy β-methylbutyrate) | grade=B+ (7.2/10) | evidence=6/10 | benefit=3.5/10 | safety=10/10 | category=Sleep & Recovery | class=Supplement | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/hmb-hydroxy-methylbutyrate.md | html=https://readofflabel.com/compound/hmb-hydroxy-methylbutyrate/ - Circadian-aligned eating | grade=B+ (7.1/10) | evidence=6/10 | benefit=5/10 | safety=9/10 | category=Sleep & Recovery | class=Protocol | legal_status=N/A | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/circadian-aligned-eating.md | html=https://readofflabel.com/compound/circadian-aligned-eating/ - HRV-guided training / biofeedback | grade=B+ (7.1/10) | evidence=6/10 | benefit=5/10 | safety=9/10 | category=Sleep & Recovery | class=Protocol | legal_status=OTC (devices: Oura, Whoop, Garmin, HeartMath) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/hrv-guided-training-biofeedback.md | html=https://readofflabel.com/compound/hrv-guided-training-biofeedback/ - Boswellia serrata (AKBA) | grade=B+ (7.1/10) | evidence=6/10 | benefit=5/10 | safety=9/10 | category=Sleep & Recovery | class=Prescription | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/boswellia-serrata-akba.md | html=https://readofflabel.com/compound/boswellia-serrata-akba/ - PEA (palmitoylethanolamide) | grade=B+ (7.1/10) | evidence=6/10 | benefit=5/10 | safety=9/10 | category=Sleep & Recovery | class=Prescription | legal_status=Rx (Italy/Spain as Normast/Pelvilen); OTC supplement elsewhere | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/pea-palmitoylethanolamide.md | html=https://readofflabel.com/compound/pea-palmitoylethanolamide/ - Doxepin (low-dose) | grade=B+ (7.1/10) | evidence=6/10 | benefit=5/10 | safety=9/10 | category=Sleep & Recovery | class=Prescription | legal_status=Rx | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/doxepin-low-dose.md | html=https://readofflabel.com/compound/doxepin-low-dose/ - Lysine (L-lysine) | grade=B+ (7.1/10) | evidence=6/10 | benefit=5/10 | safety=9/10 | category=Sleep & Recovery | class=Supplement | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/lysine-l-lysine.md | html=https://readofflabel.com/compound/lysine-l-lysine/ - Tart cherry (Prunus cerasus) | grade=B+ (7.0/10) | evidence=6/10 | benefit=2/10 | safety=10/10 | category=Sleep & Recovery | class=Herbal | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/tart-cherry-prunus-cerasus.md | html=https://readofflabel.com/compound/tart-cherry-prunus-cerasus/ - Mobility work / flexibility training | grade=B (6.8/10) | evidence=6/10 | benefit=3.5/10 | safety=9/10 | category=Sleep & Recovery | class=Protocol | legal_status=N/A | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/mobility-work-flexibility-training.md | html=https://readofflabel.com/compound/mobility-work-flexibility-training/ - PEMF therapy (pulsed electromagnetic field) | grade=B (6.8/10) | evidence=6/10 | benefit=3.5/10 | safety=9/10 | category=Sleep & Recovery | class=Protocol | legal_status=OTC (devices) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/pemf-therapy-pulsed-electromagnetic-field.md | html=https://readofflabel.com/compound/pemf-therapy-pulsed-electromagnetic-field/ - Hyaluronic acid (oral + intra-articular) | grade=B (6.8/10) | evidence=6/10 | benefit=3.5/10 | safety=9/10 | category=Sleep & Recovery | class=Supplement | legal_status=OTC (oral); Rx (intra-articular — Synvisc, Euflexxa, etc.) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/hyaluronic-acid-oral-intra-articular.md | html=https://readofflabel.com/compound/hyaluronic-acid-oral-intra-articular/ - Glutamine | grade=B (6.6/10) | evidence=6/10 | benefit=2/10 | safety=9/10 | category=Sleep & Recovery | class=Supplement | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/glutamine.md | html=https://readofflabel.com/compound/glutamine/ - Contrast therapy (hot/cold) | grade=B- (6.3/10) | evidence=6/10 | benefit=5/10 | safety=7/10 | category=Sleep & Recovery | class=Protocol | legal_status=N/A | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/contrast-therapy-hot-cold.md | html=https://readofflabel.com/compound/contrast-therapy-hot-cold/ - Glucosamine + chondroitin | grade=B- (6.3/10) | evidence=4/10 | benefit=3.5/10 | safety=10/10 | category=Sleep & Recovery | class=Supplement | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/glucosamine-chondroitin.md | html=https://readofflabel.com/compound/glucosamine-chondroitin/ - Trazodone | grade=B- (6.3/10) | evidence=6/10 | benefit=5/10 | safety=7/10 | category=Sleep & Recovery | class=Prescription | legal_status=Rx | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/trazodone.md | html=https://readofflabel.com/compound/trazodone/ - Glycine | grade=B- (6.2/10) | evidence=4.5/10 | benefit=3.5/10 | safety=9/10 | category=Sleep & Recovery | class=Supplement | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/glycine.md | html=https://readofflabel.com/compound/glycine/ - Valerian (Valeriana officinalis) | grade=B- (6.2/10) | evidence=4.5/10 | benefit=3.5/10 | safety=9/10 | category=Sleep & Recovery | class=Herbal | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/valerian-valeriana-officinalis.md | html=https://readofflabel.com/compound/valerian-valeriana-officinalis/ - Z-drugs (zolpidem / eszopiclone / zaleplon) | grade=B- (6.2/10) | evidence=8/10 | benefit=8/10 | safety=3.5/10 | category=Sleep & Recovery | class=Prescription | legal_status=Rx (Schedule IV US) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/z-drugs-zolpidem-eszopiclone-zaleplon.md | html=https://readofflabel.com/compound/z-drugs-zolpidem-eszopiclone-zaleplon/ - Thymosin alpha-1 | grade=C+ (5.7/10) | evidence=3/10 | benefit=5/10 | safety=9/10 | category=Sleep & Recovery | class=Peptide | legal_status=Rx in EU, Asia, Russia (Zadaxin); NOT FDA-approved in US; Category 2 on 503A bulks — compounding prohibited as of Jan 2025 | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/thymosin-alpha-1.md | html=https://readofflabel.com/compound/thymosin-alpha-1/ - Cold plunge / cold water immersion | grade=C+ (5.5/10) | evidence=6/10 | benefit=5/10 | safety=5/10 | category=Sleep & Recovery | class=Protocol | legal_status=N/A | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/cold-plunge-cold-water-immersion.md | html=https://readofflabel.com/compound/cold-plunge-cold-water-immersion/ - Hyperbaric oxygen therapy (HBOT) | grade=C+ (5.5/10) | evidence=6/10 | benefit=5/10 | safety=5/10 | category=Sleep & Recovery | class=Protocol | legal_status=Available at specialty clinics | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/hyperbaric-oxygen-therapy-hbot.md | html=https://readofflabel.com/compound/hyperbaric-oxygen-therapy-hbot/ - Curcumin (turmeric) | grade=C+ (5.5/10) | evidence=6/10 | benefit=5/10 | safety=5/10 | category=Sleep & Recovery | class=Supplement | legal_status=OTC (EFSA ADI 180 mg curcumin/day for 60 kg adult ≈ 3 mg/kg/day; Italian Ministry of Health required new hepatotoxicity warning labels 2024-2025) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/curcumin-turmeric.md | html=https://readofflabel.com/compound/curcumin-turmeric/ - Apigenin | grade=C+ (5.5/10) | evidence=3/10 | benefit=3.5/10 | safety=9/10 | category=Sleep & Recovery | class=Prescription | legal_status=OTC | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/apigenin.md | html=https://readofflabel.com/compound/apigenin/ - CBD (cannabidiol) | grade=C+ (5.4/10) | evidence=4.5/10 | benefit=3.5/10 | safety=7/10 | category=Sleep & Recovery | class=Prescription | legal_status=Rx (Epidiolex); OTC (supplements with poor regulation) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/cbd-cannabidiol.md | html=https://readofflabel.com/compound/cbd-cannabidiol/ - SPMs (specialized pro-resolving mediators) | grade=C (5.0/10) | evidence=2/10 | benefit=3.5/10 | safety=9/10 | category=Sleep & Recovery | class=Supplement | legal_status=OTC supplements (Metagenics, others) contain SPM-enriched fish oil fractions | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/spms-specialized-pro-resolving-mediators.md | html=https://readofflabel.com/compound/spms-specialized-pro-resolving-mediators/ - Pentosan polysulfate (Elmiron) | grade=C (4.8/10) | evidence=4.5/10 | benefit=5/10 | safety=5/10 | category=Sleep & Recovery | class=Prescription | legal_status=Rx (Elmiron — interstitial cystitis); off-label injectable (veterinary zydax) used by some humans | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/pentosan-polysulfate-elmiron.md | html=https://readofflabel.com/compound/pentosan-polysulfate-elmiron/ - THC / cannabis products | grade=C- (4.1/10) | evidence=3.5/10 | benefit=3.5/10 | safety=5/10 | category=Sleep & Recovery | class=Prescription | legal_status=Legal status varies by jurisdiction; THC/cannabis WADA S8 prohibited in competition; CBD is an exception | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/thc-cannabis-products.md | html=https://readofflabel.com/compound/thc-cannabis-products/ - High-volume IV hydration / infusion clinics | grade=D+ (3.9/10) | evidence=3/10 | benefit=3.5/10 | safety=5/10 | category=Sleep & Recovery | class=Supplement | legal_status=Medical/procedure context; WADA M2 prohibits IV infusions/injections over 100 mL per 12-hour period except legitimate medical treatment | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/high-volume-iv-hydration-infusion-clinics.md | html=https://readofflabel.com/compound/high-volume-iv-hydration-infusion-clinics/ - LL-37 (cathelicidin) | grade=D (3.3/10) | evidence=2/10 | benefit=5/10 | safety=4/10 | category=Sleep & Recovery | class=Peptide | legal_status=Not FDA-approved; research peptide | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/ll-37-cathelicidin.md | html=https://readofflabel.com/compound/ll-37-cathelicidin/ - KPV (Lys-Pro-Val) | grade=D (3.3/10) | evidence=2/10 | benefit=5/10 | safety=4/10 | category=Sleep & Recovery | class=Peptide | legal_status=Not FDA-approved; Category 2 on 503A bulks (compounding prohibited); research peptide; PCAC voted 8-6 in favour of adding KPV to the 503A bulks list (Jul 23-24, 2026) — advisory only, not an FDA approval or a final compounding decision | last_reviewed=2026-07-27 | md=https://readofflabel.com/compound/kpv-lys-pro-val.md | html=https://readofflabel.com/compound/kpv-lys-pro-val/ - BPC-157 (Body Protection Compound-157) | grade=D (2.9/10) | evidence=2/10 | benefit=5/10 | safety=3/10 | category=Sleep & Recovery | class=Peptide | legal_status=Not FDA-approved; FDA classified as Category 2 on interim 503A bulks list — prohibited from US compounding pharmacies per Jan 7, 2025 final guidance; WADA-banned; sold as research peptide; removed from the Category 2 interim list April 2026 (nominators withdrew), with an FDA Pharmacy Compounding Advisory Committee review of BPC-157 for the 503A bulks list set for July 23, 2026; PCAC voted 8-6 in favour of adding BPC-157 to the 503A bulks list (Jul 23-24, 2026) — advisory only, not an FDA approval or a final compounding decision | last_reviewed=2026-07-27 | md=https://readofflabel.com/compound/bpc-157-body-protection-compound-157.md | html=https://readofflabel.com/compound/bpc-157-body-protection-compound-157/ - TB-500 (Thymosin beta-4 fragment) | grade=D (2.9/10) | evidence=2/10 | benefit=5/10 | safety=3/10 | category=Sleep & Recovery | class=Peptide | legal_status=Not FDA-approved for any indication; Category 2 — compounding prohibited; WADA-banned; veterinary use common in horses; PCAC voted 8-6 (one abstention) in favour of adding TB-500 to the 503A bulks list (Jul 23-24, 2026) — advisory only, not an FDA approval or a final compounding decision | last_reviewed=2026-07-27 | md=https://readofflabel.com/compound/tb-500-thymosin-beta-4-fragment.md | html=https://readofflabel.com/compound/tb-500-thymosin-beta-4-fragment/ - Tramadol / prescription opioid analgesics | grade=D (2.9/10) | evidence=3/10 | benefit=5/10 | safety=2/10 | category=Sleep & Recovery | class=Prescription | legal_status=Rx/controlled status varies; WADA S7 narcotics prohibited in competition | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/tramadol-prescription-opioid-analgesics.md | html=https://readofflabel.com/compound/tramadol-prescription-opioid-analgesics/ ## Exposures and toxins (40) Ranked by exposure concern rather than benefit. A high score means the database judges the population-level concern high, not that an individual reader is exposed. - Tobacco smoke (direct / secondhand) | concern=CRITICAL (10.0/10) | evidence=10/10 | harm_magnitude=10/10 | exposure_prevalence=0/10 | category=Toxins | class=Lifestyle exposure | legal_status=WHO FCTC; indoor smoking bans; graphic warnings | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/tobacco-smoke-direct-secondhand.md | html=https://readofflabel.com/compound/tobacco-smoke-direct-secondhand/ - Sedentary behavior / sitting | concern=CRITICAL (10.0/10) | evidence=10/10 | harm_magnitude=10/10 | exposure_prevalence=0/10 | category=Toxins | class=Lifestyle exposure | legal_status=WHO guidelines: limit sedentary time | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/sedentary-behavior-sitting.md | html=https://readofflabel.com/compound/sedentary-behavior-sitting/ - Chronic sleep deprivation | concern=CRITICAL (10.0/10) | evidence=10/10 | harm_magnitude=10/10 | exposure_prevalence=0/10 | category=Toxins | class=Lifestyle exposure | legal_status=CDC/NSF 7-9 hours/night for adults | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/chronic-sleep-deprivation.md | html=https://readofflabel.com/compound/chronic-sleep-deprivation/ - Loneliness / social isolation | concern=CRITICAL (10.0/10) | evidence=10/10 | harm_magnitude=10/10 | exposure_prevalence=0/10 | category=Toxins | class=Lifestyle exposure | legal_status=US Surgeon General 2023 advisory on loneliness | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/loneliness-social-isolation.md | html=https://readofflabel.com/compound/loneliness-social-isolation/ - PM2.5 (fine particulate matter) | concern=CRITICAL (9.4/10) | evidence=10/10 | harm_magnitude=10/10 | exposure_prevalence=2/10 | category=Toxins | class=Air pollutant | legal_status=WHO 2021 guideline ≤5 μg/m³ annual; US EPA 2024 standard 9 μg/m³ | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/pm2-5-fine-particulate-matter.md | html=https://readofflabel.com/compound/pm2-5-fine-particulate-matter/ - Lead | concern=CRITICAL (9.4/10) | evidence=10/10 | harm_magnitude=10/10 | exposure_prevalence=2/10 | category=Toxins | class=Heavy metal | legal_status=CDC blood lead reference value lowered to 3.5 μg/dL in 2021; no safe level | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/lead.md | html=https://readofflabel.com/compound/lead/ - PFAS (PFOA / PFOS / GenX) | concern=CRITICAL (8.8/10) | evidence=8/10 | harm_magnitude=10/10 | exposure_prevalence=2/10 | category=Toxins | class=Endocrine disruptor | legal_status=EPA April 2024 MCL 4 ppt for PFOA/PFOS in drinking water — first binding federal limits | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/pfas-pfoa-pfos-genx.md | html=https://readofflabel.com/compound/pfas-pfoa-pfos-genx/ - Benzene | concern=CRITICAL (8.6/10) | evidence=10/10 | harm_magnitude=8/10 | exposure_prevalence=2/10 | category=Toxins | class=Air pollutant | legal_status=OSHA PEL 1 ppm 8-hr; EPA MCL drinking water 5 μg/L | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/benzene.md | html=https://readofflabel.com/compound/benzene/ - Yellow oleander-adulterated weight-loss supplements | concern=CRITICAL (8.6/10) | evidence=8/10 | harm_magnitude=8/10 | exposure_prevalence=0/10 | category=Toxins | class=Supplement adulterant | legal_status=Adulterant in products marketed as tejocote root, Brazil seed, Mexican hawthorn, or weight-loss botanicals; FDA safety alert ongoing | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/yellow-oleander-adulterated-weight-loss-supplements.md | html=https://readofflabel.com/compound/yellow-oleander-adulterated-weight-loss-supplements/ - Nitrite poppers (amyl/isobutyl nitrite products) | concern=CRITICAL (8.6/10) | evidence=8/10 | harm_magnitude=8/10 | exposure_prevalence=0/10 | category=Toxins | class=Recreational inhalant | legal_status=Unapproved products; often sold as cleaners/incense/solvents rather than approved inhaled drugs | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/nitrite-poppers-amyl-isobutyl-nitrite-products.md | html=https://readofflabel.com/compound/nitrite-poppers-amyl-isobutyl-nitrite-products/ - Chronic psychological stress | concern=CRITICAL (8.6/10) | evidence=8/10 | harm_magnitude=8/10 | exposure_prevalence=0/10 | category=Toxins | class=Lifestyle exposure | legal_status=No regulation (lifestyle) | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/chronic-psychological-stress.md | html=https://readofflabel.com/compound/chronic-psychological-stress/ - Radon | concern=CRITICAL (8.5/10) | evidence=10/10 | harm_magnitude=10/10 | exposure_prevalence=5/10 | category=Toxins | class=Air pollutant | legal_status=US EPA action level 4 pCi/L; WHO 2.7 pCi/L | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/radon.md | html=https://readofflabel.com/compound/radon/ - Alcohol (ethanol) | concern=CRITICAL (8.5/10) | evidence=10/10 | harm_magnitude=10/10 | exposure_prevalence=5/10 | category=Toxins | class=Lifestyle exposure | legal_status=WHO 2023: no safe level. Canada 2023 CCSA lowered guidance to 1-2 drinks/week | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/alcohol-ethanol.md | html=https://readofflabel.com/compound/alcohol-ethanol/ - Formaldehyde | concern=HIGH (8.0/10) | evidence=8/10 | harm_magnitude=8/10 | exposure_prevalence=2/10 | category=Toxins | class=Air pollutant | legal_status=ACGIH TLV 0.1 ppm ceiling; WHO 0.1 mg/m³ 30-min | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/formaldehyde.md | html=https://readofflabel.com/compound/formaldehyde/ - TCE (trichloroethylene) | concern=HIGH (8.0/10) | evidence=8/10 | harm_magnitude=8/10 | exposure_prevalence=2/10 | category=Toxins | class=Air pollutant | legal_status=EPA banned most uses Dec 2024; MCL drinking water 5 μg/L | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/tce-trichloroethylene.md | html=https://readofflabel.com/compound/tce-trichloroethylene/ - DMAA / DMHA stimulant adulterants | concern=HIGH (8.0/10) | evidence=8/10 | harm_magnitude=8/10 | exposure_prevalence=2/10 | category=Toxins | class=Supplement adulterant | legal_status=Unlawful dietary-supplement ingredients in the US; products subject to FDA warning/recall actions | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/dmaa-dmha-stimulant-adulterants.md | html=https://readofflabel.com/compound/dmaa-dmha-stimulant-adulterants/ - Organophosphate pesticides (chlorpyrifos / malathion) | concern=HIGH (8.0/10) | evidence=8/10 | harm_magnitude=8/10 | exposure_prevalence=2/10 | category=Toxins | class=Pesticide | legal_status=EPA 2021 chlorpyrifos food-use ban; vacated and partially reinstated in 2023-2024 legal actions | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/organophosphate-pesticides-chlorpyrifos-malathion.md | html=https://readofflabel.com/compound/organophosphate-pesticides-chlorpyrifos-malathion/ - Nitrous oxide (recreational inhalation) | concern=HIGH (8.0/10) | evidence=8/10 | harm_magnitude=8/10 | exposure_prevalence=2/10 | category=Toxins | class=Recreational inhalant | legal_status=Food-processing propellant is legal for culinary use; recreational inhalation/misuse is unsafe and not an approved use | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/nitrous-oxide-recreational-inhalation.md | html=https://readofflabel.com/compound/nitrous-oxide-recreational-inhalation/ - NO2 (nitrogen dioxide) | concern=HIGH (7.6/10) | evidence=8/10 | harm_magnitude=8/10 | exposure_prevalence=3.5/10 | category=Toxins | class=Air pollutant | legal_status=WHO 2021 annual guideline 10 μg/m³ | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/no2-nitrogen-dioxide.md | html=https://readofflabel.com/compound/no2-nitrogen-dioxide/ - Ozone (tropospheric) | concern=HIGH (7.6/10) | evidence=8/10 | harm_magnitude=8/10 | exposure_prevalence=3.5/10 | category=Toxins | class=Air pollutant | legal_status=US EPA NAAQS 70 ppb 8-hr; WHO 100 μg/m³ 8-hr | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/ozone-tropospheric.md | html=https://readofflabel.com/compound/ozone-tropospheric/ - Aflatoxins | concern=HIGH (7.3/10) | evidence=10/10 | harm_magnitude=10/10 | exposure_prevalence=9/10 | category=Toxins | class=Mycotoxin | legal_status=FDA action level 20 ppb for food; 0.5 ppb for milk | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/aflatoxins.md | html=https://readofflabel.com/compound/aflatoxins/ - Arsenic | concern=HIGH (7.1/10) | evidence=8/10 | harm_magnitude=8/10 | exposure_prevalence=5/10 | category=Toxins | class=Heavy metal | legal_status=EPA MCL drinking water 10 μg/L (debate over lower); FDA action levels for rice in infant cereals | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/arsenic.md | html=https://readofflabel.com/compound/arsenic/ - Phthalates (DEHP / DBP / BBP / DEP) | concern=MODERATE (6.2/10) | evidence=7/10 | harm_magnitude=6.5/10 | exposure_prevalence=5/10 | category=Toxins | class=Endocrine disruptor | legal_status=California banned 5 phthalates in personal care 2021; EU restricts; US regulation fragmented | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/phthalates-dehp-dbp-bbp-dep.md | html=https://readofflabel.com/compound/phthalates-dehp-dbp-bbp-dep/ - Mercury (methylmercury) | concern=MODERATE (5.9/10) | evidence=8/10 | harm_magnitude=5/10 | exposure_prevalence=5/10 | category=Toxins | class=Heavy metal | legal_status=EPA reference dose 0.1 μg/kg/day; FDA/EPA 2021 seafood advisory | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/mercury-methylmercury.md | html=https://readofflabel.com/compound/mercury-methylmercury/ - Fluoride (high-dose) | concern=MODERATE (5.9/10) | evidence=8/10 | harm_magnitude=8/10 | exposure_prevalence=9/10 | category=Toxins | class=Water contaminant | legal_status=WHO 1.5 mg/L guideline; EPA MCL 4 mg/L (widely considered too high); US EPA 2024 federal court ruling requires TSCA risk evaluation | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/fluoride-high-dose.md | html=https://readofflabel.com/compound/fluoride-high-dose/ - Cadmium | concern=MODERATE (5.3/10) | evidence=8/10 | harm_magnitude=5/10 | exposure_prevalence=7/10 | category=Toxins | class=Heavy metal | legal_status=JECFA tolerable weekly intake 2.5 μg/kg; no safe threshold for kidney | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/cadmium.md | html=https://readofflabel.com/compound/cadmium/ - PBDEs (polybrominated diphenyl ethers) | concern=MODERATE (5.3/10) | evidence=8/10 | harm_magnitude=5/10 | exposure_prevalence=7/10 | category=Toxins | class=Endocrine disruptor | legal_status=Phased out 2004-2013; replacements (Firemaster 550, chlorinated TBBPA) have similar concerns | last_reviewed=2026-07-11 | md=https://readofflabel.com/compound/pbdes-polybrominated-diphenyl-ethers.md | html=https://readofflabel.com/compound/pbdes-polybrominated-diphenyl-ethers/ - PAHs (polycyclic aromatic hydrocarbons — grilled meats, air) | concern=MODERATE (5.3/10) | evidence=8/10 | harm_magnitude=5/10 | exposure_prevalence=7/10 | category=Toxins | class=Cooking byproduct | legal_status=California Prop 65 warnings; AMA/ACS recommendations for cooking method | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/pahs-polycyclic-aromatic-hydrocarbons-grilled-meats-air.md | html=https://readofflabel.com/compound/pahs-polycyclic-aromatic-hydrocarbons-grilled-meats-air/ - Blue light (evening artificial light at night) | concern=MODERATE (5.3/10) | evidence=8/10 | harm_magnitude=5/10 | exposure_prevalence=7/10 | category=Toxins | class=Lifestyle exposure | legal_status=Best-practice lighting guidance (not regulation); many OSes/apps offer night mode | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/blue-light-evening-artificial-light-at-night.md | html=https://readofflabel.com/compound/blue-light-evening-artificial-light-at-night/ - BPA / BPS / BPF (bisphenols) | concern=MODERATE (4.7/10) | evidence=6/10 | harm_magnitude=5/10 | exposure_prevalence=7/10 | category=Toxins | class=Endocrine disruptor | legal_status=EFSA 2023 dramatically lowered TDI to 0.2 ng/kg/day from 4 μg/kg/day; FDA has not followed | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/bpa-bps-bpf-bisphenols.md | html=https://readofflabel.com/compound/bpa-bps-bpf-bisphenols/ - Acrylamide (high-heat cooking) | concern=MODERATE (4.7/10) | evidence=6/10 | harm_magnitude=3.5/10 | exposure_prevalence=5/10 | category=Toxins | class=Cooking byproduct | legal_status=California Prop 65 listing drove coffee warnings (reversed 2018); FDA guidance but no federal limit | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/acrylamide-high-heat-cooking.md | html=https://readofflabel.com/compound/acrylamide-high-heat-cooking/ - Neonicotinoids (imidacloprid / clothianidin) | concern=MODERATE (4.7/10) | evidence=8/10 | harm_magnitude=5/10 | exposure_prevalence=9/10 | category=Toxins | class=Pesticide | legal_status=EU banned outdoor use of 3 major neonics 2018; US allows most uses | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/neonicotinoids-imidacloprid-clothianidin.md | html=https://readofflabel.com/compound/neonicotinoids-imidacloprid-clothianidin/ - Triclosan / triclocarban | concern=MODERATE (4.1/10) | evidence=6/10 | harm_magnitude=3.5/10 | exposure_prevalence=7/10 | category=Toxins | class=Endocrine disruptor | legal_status=FDA 2016 banned from consumer antibacterial soaps; Colgate reformulated Total without triclosan in 2019 | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/triclosan-triclocarban.md | html=https://readofflabel.com/compound/triclosan-triclocarban/ - Ochratoxin A | concern=MODERATE (4.1/10) | evidence=6/10 | harm_magnitude=3.5/10 | exposure_prevalence=7/10 | category=Toxins | class=Mycotoxin | legal_status=EFSA TDI 17 ng/kg/day; varies by country | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/ochratoxin-a.md | html=https://readofflabel.com/compound/ochratoxin-a/ - DBPs (disinfection byproducts — trihalomethanes, haloacetic acids) | concern=MODERATE (4.1/10) | evidence=6/10 | harm_magnitude=3.5/10 | exposure_prevalence=7/10 | category=Toxins | class=Endocrine disruptor | legal_status=EPA MCL THMs 80 μg/L, HAAs 60 μg/L | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/dbps-disinfection-byproducts-trihalomethanes-haloacetic-acids.md | html=https://readofflabel.com/compound/dbps-disinfection-byproducts-trihalomethanes-haloacetic-acids/ - EMF / RF exposure (cell phones, Wi-Fi) | concern=LOW (3.9/10) | evidence=4.5/10 | harm_magnitude=4/10 | exposure_prevalence=7/10 | category=Toxins | class=Lifestyle exposure | legal_status=FCC SAR limits; WHO/IARC review pending update; 2024 NTP rat studies showed cardiac schwannoma in male rats at high exposures | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/emf-rf-exposure-cell-phones-wi-fi.md | html=https://readofflabel.com/compound/emf-rf-exposure-cell-phones-wi-fi/ - Glyphosate (Roundup) | concern=LOW (3.8/10) | evidence=3/10 | harm_magnitude=5/10 | exposure_prevalence=7/10 | category=Toxins | class=Pesticide | legal_status=EPA interim registration decision 2020 (litigation ongoing); banned/restricted in many countries; Bayer $10B+ in Roundup litigation settlements | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/glyphosate-roundup.md | html=https://readofflabel.com/compound/glyphosate-roundup/ - Parabens (methyl / propyl / butyl) | concern=LOW (3.7/10) | evidence=4.5/10 | harm_magnitude=3.5/10 | exposure_prevalence=7/10 | category=Toxins | class=Endocrine disruptor | legal_status=EU restricts propyl/butyl in children's products; Darbre 2004 breast tumor tissue detection controversial | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/parabens-methyl-propyl-butyl.md | html=https://readofflabel.com/compound/parabens-methyl-propyl-butyl/ - Microplastics / nanoplastics | concern=LOW (3.4/10) | evidence=3/10 | harm_magnitude=4/10 | exposure_prevalence=7/10 | category=Toxins | class=Water contaminant | legal_status=No regulation yet; EU single-use plastics directive addresses sources | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/microplastics-nanoplastics.md | html=https://readofflabel.com/compound/microplastics-nanoplastics/ - Aluminum | concern=LOW (3.1/10) | evidence=4.5/10 | harm_magnitude=3.5/10 | exposure_prevalence=9/10 | category=Toxins | class=Heavy metal | legal_status=ATSDR MRL 1 mg/kg/day oral | last_reviewed=2026-06-08 | md=https://readofflabel.com/compound/aluminum.md | html=https://readofflabel.com/compound/aluminum/