Newsletter Frontier science. No hype.
Evidence-first dispatches
from the frontier
of science.
Every week: evidence updates on longevity, performance, cognition, biohacking, and more.
New Get your optimized stack in 5 minutes →What's inside
Not another supplement listicle.
Protocol deep-dives
A systematic review of evidence, presented in an easy to digest format.
Evidence grading
Every compound tiered S–F across evidence, benefit, and safety — never just one number.
Frontier signals
Pre-print radar: notable papers before they hit mainstream science journalism.
Stack updates
How new data changes practical stacks — what to add, adjust, or drop.
Protocol database
Every compound. Graded.
Our living index of longevity compounds, nootropics, and protocols — scored by evidence quality and updated with each issue.
Longevity
| Compound | Class | Ev | Bn | Sf | Grade |
|---|---|---|---|---|---|
| Resistance training | Protocol | 10 | 8 | 9 | S 9.3 |
| VO2 max / HIIT | Protocol | 10 | 8 | 7 | S 8.5 |
| CoQ10 (ubiquinone/ubiquinol) | Supplement | 8 | 6.5 | 9 | A+ 8.2 |
| Lutein + Zeaxanthin | Herbal | 8 | 6.5 | 9 | A+ 8.2 |
| Meditation / mindfulness | Protocol | 8 | 6.5 | 9 | A+ 8.2 |
| Tretinoin (all-trans retinoic acid) | Prescription | 10 | 10 | 5 | A 8 |