Evidence you can inspect.

What this project does

The database applies one published rubric to lifestyle interventions, supplements, prescription drugs, experimental compounds, and environmental or behavioral exposures. Each entry separates evidence quality, likely benefit, and safety, then links to the sources used. The score is a compact index—not a verdict for every person, diagnosis, dose, or outcome.

Read Off Label presents evidence of benefits, harms, uncertainty, studied or reported use contexts, and legal status. It does not decide whether an intervention is appropriate for an individual.

The weekly newsletter is the change feed: important new evidence, score movements, corrections, and frontier findings that are clearly labeled as early.

Why it exists

Health information is difficult to evaluate because strong clinical evidence, biological plausibility, marketing, and personal anecdotes are often presented as if they were equivalent. Read Off Label makes those differences visible so readers can ask better questions and make informed decisions with qualified professionals.

How entries are reviewed

• Human outcomes and high-quality syntheses take priority over mechanisms and animal data.
• The population, indication, comparator, outcome, dose, and duration matter; a result is not assumed to generalize beyond them.
• Safety is shown separately because one composite cannot resolve a benefit–harm trade-off for an individual.
• Conference abstracts, preprints, and company toplines are labeled provisional and should not be treated like peer-reviewed trials.
• Material changes and corrections are recorded in the public archive.

The complete rubric and its limitations are on the methodology page.

Who is responsible

The editor is not a doctor, pharmacist, or any kind of medical professional, and nothing on this site is medical advice. It is not a medical review, a diagnosis, or treatment guidance, and no clinician has reviewed it. Read Off Label is independently produced and has no institutional affiliation.

That limitation is the reason the project is built the way it is. Instead of asking readers to trust a grade, it shows the work: the rubric is published in full, every entry links to the sources behind it, and every material change is dated in the public archive. The scores are an index over published evidence, not a clinical opinion — check the sources, and take decisions about your own health to someone qualified to make them with you.

Funding and conflicts

Scores are not sold and sponsors do not receive editorial control. The project may earn revenue from clearly disclosed affiliate links or sponsorships. A commercial relationship must never change a score, suppress a correction, or determine which evidence is included. See the full disclosure.

Corrections

If a citation is unrelated, a claim overreaches the study, or a safety detail is missing, please send the intervention name, the disputed sentence, and the best primary source you have. Substantive corrections are dated publicly.

admin@readofflabel.com