What this site is, and isn't.

Individual applicability

The database does not determine whether an intervention is appropriate for a particular person. Health history, medications, labs, goals, formulation, dose, and monitoring can change both benefits and harms. A licensed healthcare professional can help interpret those factors for an individual.

Off-label use carries real risk

Much of what is covered here is off-label — used outside the specific indications for which a drug is approved. Off-label use may be supported by evidence, but the evidence base and the regulatory or prescribing guardrails can differ from those for an approved indication. Each entry presents the reported use, evidence, safety, and legal context without deciding use for the reader.

The scores are opinions

Evidence, Effectiveness, and Risk scores reflect the author's reading of the published literature at the time of scoring. Reasonable experts can and do disagree. Scores move as new research arrives or as errors are pointed out. See the archive for every change.

Legality varies by jurisdiction

Some compounds discussed here are prescription-only, controlled, or illegal in certain countries, states, or sports-testing contexts. The status shown is contextual and may change or differ by jurisdiction. Nothing on this site should be taken as encouragement to obtain any substance outside of legal channels.

Affiliate disclosure

Some links on this site are affiliate links: if you buy through them, the author may earn a commission at no extra cost to you. Commissions never influence scores, rankings, or coverage — products are scored from the published literature before any purchase link is attached, and no brand can pay for placement or a better grade. Every score change is logged publicly in the archive. Sponsored newsletter placements, when they occur, are always clearly labeled as such.

Liability

You use this site at your own risk. The author disclaims all liability, to the maximum extent permitted by law, for any outcome — injury, illness, financial loss, or otherwise — arising from any use or misuse of the information presented. By using this site you agree that your health decisions remain your own responsibility; the site does not make them on your behalf.