Newsletter Frontier science. No hype.
Evidence-first dispatches
from the frontier
of science.
Every week: evidence updates on longevity, performance, cognition, biohacking, and more.
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What's inside
Not another supplement listicle.
Protocol deep-dives
A systematic review of evidence, presented in an easy to digest format.
Evidence grading
Every compound tiered S–F across evidence, benefit, and safety — never just one number.
Frontier signals
Preprint radar: early findings, clearly labeled before peer review.
Stack updates
How new data changes the case for an intervention — including when evidence gets weaker.
Protocol database
Every compound. Graded.
Our living index of longevity compounds, nootropics, and protocols — scored by evidence quality and updated with each issue.
Longevity
| Compound | Class | Ev | Bn | Sf | Grade |
|---|---|---|---|---|---|
| Resistance training | Protocol | 10 | 8 | 9 | S 9.3 |
| VO2 max / HIIT | Protocol | 10 | 8 | 7 | S 8.5 |
| CoQ10 (ubiquinone/ubiquinol) | Supplement | 8 | 6.5 | 9 | A+ 8.2 |
| Lutein + Zeaxanthin | Herbal | 8 | 6.5 | 9 | A+ 8.2 |
| Meditation / mindfulness | Protocol | 8 | 6.5 | 9 | A+ 8.2 |
| Tretinoin (all-trans retinoic acid) | Prescription | 10 | 10 | 5 | A 8 |
Two other ways in
The grade is not the only question.
The database sorts by how well established something is. Two questions it cannot answer: how much would this matter if it worked, and when will we know? Each has its own page.
If it worked, how much would it matter? Frontier 39 interventions ranked by potential rather than evidence, each with what
the ceiling rests on and why it may not translate. A watch list, not a try list —
7 of the 10 assessed for it have no outcome a person
could measure at all.
See the frontier → When will we know? Upcoming 7 compounds with a trial or regulatory readout due in roughly six months,
and 6 just entering human testing. This is where the rankings are most
likely to move next.
See what's due →