Original analysis

What one rubric applied to 440 entries shows.

Every entry in this database is scored with the same published rubric — 45% Evidence, 15% Benefit, 40% Safety. Scoring a deliberately mixed set that way makes some patterns visible that no single review does. These are descriptive statistics about the database, updated whenever the data is.

Last entry review: Jul 27, 2026 · 400 graded interventions · 40 exposure entries

34%

of the 400 graded interventions covered here rest on Strong or Very Strong human evidence (136 of 400).

19.5%

carry a high-risk evidence profile — a Safety score of 3.5 or below (78 of 400).

39%

involve a prescription form in at least one jurisdiction or route (156 of 400).

6/10

is the median Evidence score. Median Safety is 7/10 and the median composite is 6.2/10.

How grades are distributed

The rubric is not curved. Grades fall where the evidence, benefit, and safety inputs put them, which is why the distribution clusters in the B and C bands rather than spreading evenly.

GradeEntriesShare
S 8 2%
A+ 15 3.8%
A 13 3.3%
A- 14 3.5%
B+ 59 14.8%
B 66 16.5%
B- 49 12.3%
C+ 69 17.3%
C 37 9.3%
C- 15 3.8%
D+ 14 3.5%
D 34 8.5%
D- 3 0.8%
F 4 1%

Median score by class

Grouping by what a thing is shows a wide spread. Groups smaller than eight entries are left out because a median over a handful of rows is not worth reporting.

ClassEntries Median compositeMedian evidenceMedian safety
Vitamin 11 7.5 8 9
Protocol 23 7.1 6 7
Supplement 90 6.5 6 9
Hormone 15 6.4 8 5
Mineral 10 6.3 8 6
Prescription 133 6.3 8 5
Herbal 32 6.2 4.5 9
Peptide 20 5.3 2.8 9
Anabolic 33 4.9 6 3.5
Research chemical 28 4.5 3 4

Median score by category

Entries are cross-listed, so a compound studied for two goals counts in both columns. Totals across categories therefore exceed 400.

CategoryEntries Median compositeMedian evidenceMedian safety
Essentials 37 7.1 8 9
Mitochondria & Cellular Energy 28 7.1 6 9
Immune & Inflammation 53 6.8 6 9
Mood, Anxiety & Stress 52 6.5 6 6
Metabolic Health 88 6.4 6 5
Sleep & Recovery 69 6.3 6 9
Longevity 59 6.3 6 9
Hormones & Endocrine 51 6.2 6 5
Cognitive 77 5.7 6 7
Muscle & Strength 58 5.4 6 4.5
Detox 16 5.4 3 9

How current the data is

400 of 400 graded entries (100%) were reviewed within twelve months of the most recent review in the dataset. Review dates run from Jun 7, 2026 to Jul 27, 2026. Every material change is dated in the public archive.

What these numbers are not

These describe the entries covered in this database, not health interventions in general. The entry list is curated toward what readers of a longevity and health-optimisation publication ask about, which deliberately oversamples frontier and experimental topics relative to routine clinical practice. A figure like the Strong-evidence share is therefore a fact about this database's coverage; reading it as an estimate of the wider literature would misuse a convenience sample.

Scores summarise published evidence in studied populations. They do not predict an individual's response, and a grade does not establish that an intervention is appropriate, effective, or safe for any particular person. The full rubric, its weights, and its limitations are on the methodology page.

Citing this analysis

These figures are free to quote with attribution to Read Off Label and a link to this page. Please carry the denominator with the number — "34% of the 400 graded interventions in the Read Off Label database" rather than "34% of supplements". The whole dataset is available as a plain-text index, and every entry has a Markdown representation at /compound/<slug>.md.