Deca-Durabolin (nandrolone decanoate)
Muscle & Strength · Injectable 19-nor steroid
Tier C+
High-risk evidence profile
Bottom line
Read Off Label grades Deca-Durabolin (nandrolone decanoate) as C+ (5.6/10) based on strong evidence, high benefit magnitude, and a high-risk safety profile.
Its high-risk evidence profile reflects a Safety score of 2/10; reported benefits and harms can differ by indication, dose, route, duration, and population.
Famously 'joint-friendly' — many anecdotes of subjective joint relief.
Studied, labeled, or reported-use context: Clinical: 50-100 mg IM every 2-4 weeks; illicit: 200-600 mg/week — Schedule III US; Rx for anemia/wasting in some countries; banned sport; not individualized guidance.
What the evidence says
Famously 'joint-friendly' — many anecdotes of subjective joint relief. Very slow release (half-life ~6-15 days). Long detection window in sport testing. Recovery of HPG axis can take 6-18 months post-cycle.
Mechanism
Nandrolone (19-nortestosterone) with long decanoate ester; AR agonist with reduced DHT conversion; progestogenic activity; joint/collagen synthesis benefits
Studied, labeled, or reported dose & route
Clinical: 50-100 mg IM every 2-4 weeks; illicit: 200-600 mg/week
This records doses and routes described in studies, approved labeling, clinical practice, or documented use. It is not individualized guidance and does not establish safety; context changes with indication, formulation, health history, monitoring, and other medicines.
Citations
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Common questions
- What does the evidence show about Deca-Durabolin (nandrolone decanoate)'s effects?
- Read Off Label rates the evidence for Deca-Durabolin (nandrolone decanoate) as Strong and the benefit magnitude as high, producing an overall grade of C+ (5.6/10). Famously 'joint-friendly' — many anecdotes of subjective joint relief.
- What safety findings are reported for Deca-Durabolin (nandrolone decanoate)?
- Deca-Durabolin (nandrolone decanoate) has a high risk profile in the database. High ('deca dick' — long-lasting HPG suppression and ED; progesterone-driven gyno; prolactin elevation; 19-nor metabolites detectable for up to 18 months) Legal status: Schedule III US; Rx for anemia/wasting in some countries; banned sport.
- What does the low Safety score for Deca-Durabolin (nandrolone decanoate) represent?
- The Safety score is 2/10. It records the substantial harms described for one or more use contexts; the Benefit score, indication, dose, route, duration, population, and legal status remain separate parts of the evidence profile.
- What doses or routes are reported for Deca-Durabolin (nandrolone decanoate)?
- Clinical: 50-100 mg IM every 2-4 weeks; illicit: 200-600 mg/week This is context from studies, approved labeling, clinical practice, or documented use; it is not individualized guidance and does not establish safety.
- How does Deca-Durabolin (nandrolone decanoate) work?
- Nandrolone (19-nortestosterone) with long decanoate ester; AR agonist with reduced DHT conversion; progestogenic activity; joint/collagen synthesis benefits
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.