Pentosan polysulfate (Elmiron)
Recovery · Semisynthetic heparinoid
Tier C
What this is
Elmiron received a 2020 FDA label update for pigmentary maculopathy risk — major class-action litigation followed. 'PPS injections' are a fringe human biohacker use of the veterinary formulation for joints, outside of any approved indication.
Mechanism
Semisynthetic sulfated xylan polysaccharide; weak anticoagulant; reported DMOAD-like (disease-modifying) effects on osteoarthritis via cartilage matrix support and reduced proteolytic damage
Dose & route
100 mg PO 3x/day (Elmiron); 3 mg/kg IM weekly x4 (veterinary adaptation)
Citations
- https://pubmed.ncbi.nlm.nih.gov/31676033/
- https://www.fda.gov/drugs/drug-safety-and-availability/fda-approves-label-changes-elmiron-pentosan-polysulfate-sodium-reflect-risk-pigmentary-maculopathy
- https://pubmed.ncbi.nlm.nih.gov/31404769/
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.