First time here
Three doors in.
Read Off Label is a database of every compound, drug, and protocol claimed to make you healthier — graded on evidence × benefit × safety, transparently. 378 entries. If you don't know where to start, pick a door.
Door 1 · Best-supported
What we'd actually tell a friend to do.
The Tier-A entries — composite score of 7.6 or higher. Boring at the top (sleep, resistance training, omega-3) is a feature, not a bug. The highest-evidence interventions are the most-evidenced for a reason.
- A+ Rosuvastatin / atorvastatin (statins) 8.9
- A+ Tadalafil (Cialis) 8.9
- A Creatine monohydrate 8.7
- A PCSK9 inhibitors (evolocumab / alirocumab / inclisiran) 8.6
- A Psyllium husk 8.5
- A Vitamin D (cholecalciferol / D3) 8.5
- A Minoxidil (topical + oral low-dose) 8.5
- A Azelaic acid 8.5
- A Milk thistle (silymarin / silibinin) 8.5
- A AREDS2 formula 8.5
- A Sleep 8.4
- A Balanced diet (Mediterranean) 8.4
Door 2 · Most overhyped
Names you've heard 100 times. The data is thinner.
Compounds with podcast / supplement-aisle reach far exceeding their human-evidence base. Most are not bad — they're just not what their marketing claims. The composite score reflects the gap.
Door 3 · Highest-risk / clinician-only
We rank these for completeness. Don't self-experiment.
Hormones, peptides, SARMs, controlled substances, off-label longevity drugs, and compounds with fatal-dose proximity. Every one of these pages carries a clinician-supervised banner — read it before reading anything else.
- A- Lp(a)-lowering therapies (olpasiran / pelacarsen / lepodisiran / zerlasiran / muvalaplin) 7.9
- A- Glutathione (liposomal / IV / S-acetyl) 7.7
- B+ Retatrutide 7.4
- B+ Obicetrapib 7.4
- B+ DORAs (suvorexant / lemborexant / daridorexant) 7.4
- B+ GHK-Cu (copper peptide) 7.3
- B+ Progesterone (micronized / oral / vaginal) 7.3
- B+ Melatonin 7.3
- B+ Modafinil 7.2
- B+ Armodafinil 7.2
- B+ Romosozumab (Evenity) 7.2
- B+ Iron 7.1