Boswellia serrata (AKBA)
Recovery · Boswellic acid / 5-LOX inhibitor
Tier B
What this is
Distinct mechanism from NSAIDs allows combination. 5-Loxin (high-AKBA) trials most impressive for knee OA. Less GI bleeding risk than NSAIDs. Often combined with curcumin for synergy.
Mechanism
Acetyl-11-keto-β-boswellic acid (AKBA) is the principal active; selective non-redox 5-lipoxygenase inhibitor; reduces leukotriene production; anti-inflammatory with distinct mechanism from NSAIDs
Dose & route
100-500 mg/day standardized extract (30-65% boswellic acids; AKBA 10-30%)
Citations
- https://pubmed.ncbi.nlm.nih.gov/18667054/
- https://pubmed.ncbi.nlm.nih.gov/29657381/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC7711410/
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.