Rankings / Sleep
Sleep
Pharmacological and supplemental sleep aids — melatonin, magnesium, orexin antagonists, z-drugs, trazodone. Ranked on effect size vs. next-day cognitive cost.
Compounds ranked
10
Scoring
| # | Compound | Ev | Bn | Sf | Grade · Score |
|---|---|---|---|---|---|
| 1 | DORAs (suvorexant / lemborexant / daridorexant) Orexin receptor antagonists | 8.0 | 8.0 | 7.0 | B+ 7.4 |
| 2 | Melatonin Pineal hormone | 8.0 | 3.5 | 9.0 | B+ 7.3 |
| 3 | Magnesium (glycinate / threonate / malate) Mineral cofactor | 6.0 | 5.0 | 9.0 | B 6.9 |
| 4 | Z-drugs (zolpidem / eszopiclone / zaleplon) GABA-A alpha-1 positive modulators | 8.0 | 8.0 | 3.5 | B 6.7 |
| 5 | CBD (cannabidiol) Non-psychoactive cannabinoid | 8.0 | 3.5 | 7.0 | B 6.4 |
| 6 | Doxepin (low-dose) H1 antagonist (low dose) | 6.0 | 5.0 | 9.0 | B- 6.3 |
| 7 | Trazodone 5-HT2A antagonist / SARI | 6.0 | 5.0 | 7.0 | B- 6.0 |
| 8 | Glycine Amino acid / NMDA co-agonist | 4.5 | 3.5 | 9.0 | B- 5.9 |
| 9 | Valerian (Valeriana officinalis) Herbal sedative | 4.5 | 3.5 | 9.0 | B- 5.9 |
| 10 | Apigenin Flavonoid / GABA-A modulator | 3.0 | 3.5 | 9.0 | C+ 5.3 |