Apigenin
Sleep · Flavonoid / GABA-A modulator
Tier C+
What this is
Huberman-driven popularization (magnesium threonate + apigenin + theanine). Chamomile tea is the traditional dietary source. Mechanism plausible; dedicated trials in humans minimal. Reasonable component of a sleep stack but not a replacement for sleep hygiene.
Mechanism
Flavonoid from chamomile, parsley, celery; GABA-A receptor binding (benzodiazepine site partial agonist); mild anxiolytic/sedative; aromatase inhibition (modest estradiol reduction)
Dose & route
50 mg before bed (popularized dose from Huberman sleep stack)
Citations
- https://pubmed.ncbi.nlm.nih.gov/7617761/
- https://pubmed.ncbi.nlm.nih.gov/22191794/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC7967604/
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.