Rankings / Longevity — Pharma (Off-Label)
Acarbose
Longevity · Alpha-glucosidase inhibitor
Tier B-
What this is
ITP: extended male mouse lifespan by 22%, female by 5% — one of the most robust ITP findings. Human longevity data is extrapolated from diabetes trials and Japanese cohort data. Cheap and well-tolerated if GI side effects are acceptable.
Mechanism
Inhibits intestinal alpha-glucosidases; slows carbohydrate digestion; blunts postprandial glucose spike; produces more favorable microbiome (SCFA production)
Dose & route
25-100 mg TID with first bite of meals
Citations
- https://pmc.ncbi.nlm.nih.gov/articles/PMC6413665/
- https://www.nia.nih.gov/news/diabetes-drug-increases-lifespan-male-mice-shows-smaller-effect-females
- https://onlinelibrary.wiley.com/doi/10.1111/acel.13088
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.