Allulose
Metabolic Health · Rare sugar / sweetener
Tier B
Bottom line
Read Off Label grades Allulose as B (6.8/10) based on moderate evidence, low-med benefit magnitude, and a low-risk safety profile.
Small trials report attenuated postprandial glucose when allulose is co-ingested with carbohydrate rather than only replacing sugar.
Studied, labeled, or reported-use context: 5-15 g per meal; up to ~0. — OTC; not individualized guidance.
What the evidence says
Small trials report attenuated postprandial glucose when allulose is co-ingested with carbohydrate rather than only replacing sugar. Long-term outcome data are limited. Retail cost is often about ten times that of sucrose. Commercial keto products commonly blend it with monk fruit or erythritol.
Mechanism
D-psicose, a C-3 epimer of fructose; ~70% sweetness of sucrose with ~0.4 kcal/g; absorbed but not metabolized by humans, excreted unchanged in urine; small-intestine inhibition of alpha-glucosidase blunts postprandial glucose when co-ingested with sucrose/starch
Studied, labeled, or reported dose & route
5-15 g per meal; up to ~0.4 g/kg single dose without GI symptoms
This records doses and routes described in studies, approved labeling, clinical practice, or documented use. It is not individualized guidance and does not establish safety; context changes with indication, formulation, health history, monitoring, and other medicines.
Citations
A link means the source informed this entry; it does not mean every claim on the page comes from that source. If a citation looks wrong or you want a claim re-checked, send a correction.
Common questions
- What does the evidence show about Allulose's effects?
- Read Off Label rates the evidence for Allulose as Moderate and the benefit magnitude as low-med, producing an overall grade of B (6.8/10). Small trials report attenuated postprandial glucose when allulose is co-ingested with carbohydrate rather than only replacing sugar.
- What safety findings are reported for Allulose?
- Allulose has a low risk profile in the database. Low (GI upset and osmotic diarrhea at >0.5 g/kg single dose; well-tolerated below that; GRAS in US since 2012; FDA exempted from 'added sugars' label 2019) Legal status: OTC.
- What doses or routes are reported for Allulose?
- 5-15 g per meal; up to ~0.4 g/kg single dose without GI symptoms This is context from studies, approved labeling, clinical practice, or documented use; it is not individualized guidance and does not establish safety.
- How does Allulose work?
- D-psicose, a C-3 epimer of fructose; ~70% sweetness of sucrose with ~0.4 kcal/g; absorbed but not metabolized by humans, excreted unchanged in urine; small-intestine inhibition of alpha-glucosidase blunts postprandial glucose when co-ingested with sucrose/starch
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.