Anadrol (oxymetholone)
Muscle & Strength · Oral anabolic steroid
Tier C
Bottom line
Read Off Label grades Anadrol (oxymetholone) as C (5.1/10) based on strong evidence, very high benefit magnitude, and a very high-risk safety profile.
The most dramatic 'size' oral — 5-10 kg in first 2-3 weeks common, but much is water.
Typical use: Clinical: 1-5 mg/kg/day in anemia; illicit 50-150 mg/day PO — Schedule III US; Rx (anaemia) as Anadrol-50; banned sport.
What this is
The most dramatic 'size' oral — 5-10 kg in first 2-3 weeks common, but much is water. Most hepatotoxic common AAS. Paradoxical gyno mechanism debated — possibly direct estrogen receptor interaction. Used clinically in aplastic anemia and HIV wasting historically. Very high Benefit reflects mass/strength effects; very low Safety reflects nonmedical high-dose oral AAS use.
Mechanism
Potent C17-aa DHT derivative; not aromatized but displays estrogenic side effects via unclear mechanism; massive water/glycogen retention; used historically for anemia
Dose & route
Clinical: 1-5 mg/kg/day in anemia; illicit 50-150 mg/day PO
Citations
- https://pubmed.ncbi.nlm.nih.gov/14744777/
- https://pubmed.ncbi.nlm.nih.gov/16084815/
- https://pubmed.ncbi.nlm.nih.gov/15705014/
- https://www.ncbi.nlm.nih.gov/books/NBK482418/
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Common questions
- Does Anadrol (oxymetholone) work?
- Read Off Label rates the evidence for Anadrol (oxymetholone) as Strong and the benefit magnitude as very high, producing an overall grade of C (5.1/10). The most dramatic 'size' oral — 5-10 kg in first 2-3 weeks common, but much is water.
- Is Anadrol (oxymetholone) safe?
- Anadrol (oxymetholone) has a very high risk profile in published human data. Legal status: Schedule III US; Rx (anaemia) as Anadrol-50; banned sport. This is not medical advice — see the disclaimer.
- What is the typical dose for Anadrol (oxymetholone)?
- Clinical: 1-5 mg/kg/day in anemia; illicit 50-150 mg/day PO
- How does Anadrol (oxymetholone) work?
- Potent C17-aa DHT derivative; not aromatized but displays estrogenic side effects via unclear mechanism; massive water/glycogen retention; used historically for anemia
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.