Anadrol (oxymetholone)
Muscle & Strength · Oral anabolic steroid
Tier C
High-risk evidence profile
Bottom line
Read Off Label grades Anadrol (oxymetholone) as C (5.1/10) based on strong evidence, very high benefit magnitude, and a very high-risk safety profile.
Its high-risk evidence profile reflects a Safety score of 0/10; reported benefits and harms can differ by indication, dose, route, duration, and population.
The most dramatic 'size' oral — 5-10 kg in first 2-3 weeks common, but much is water.
Studied, labeled, or reported-use context: Clinical: 1-5 mg/kg/day in anemia; illicit 50-150 mg/day PO — Schedule III US; Rx (anaemia) as Anadrol-50; banned sport; not individualized guidance.
Citation correction in progress
1 PubMed link was found to be unrelated to this entry and removed from public output. The remaining sources are shown below, but this row's claims and score still need a full source-by-source revalidation.
What the evidence says
The most dramatic 'size' oral — 5-10 kg in first 2-3 weeks common, but much is water. Most hepatotoxic common AAS. Paradoxical gyno mechanism debated — possibly direct estrogen receptor interaction. Used clinically in aplastic anemia and HIV wasting historically. Very high Benefit reflects mass/strength effects; very low Safety reflects nonmedical high-dose oral AAS use.
Mechanism
Potent C17-aa DHT derivative; not aromatized but displays estrogenic side effects via unclear mechanism; massive water/glycogen retention; used historically for anemia
Studied, labeled, or reported dose & route
Clinical: 1-5 mg/kg/day in anemia; illicit 50-150 mg/day PO
This records doses and routes described in studies, approved labeling, clinical practice, or documented use. It is not individualized guidance and does not establish safety; context changes with indication, formulation, health history, monitoring, and other medicines.
Citations
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Common questions
- What does the evidence show about Anadrol (oxymetholone)'s effects?
- Read Off Label rates the evidence for Anadrol (oxymetholone) as Strong and the benefit magnitude as very high, producing an overall grade of C (5.1/10). The most dramatic 'size' oral — 5-10 kg in first 2-3 weeks common, but much is water.
- What safety findings are reported for Anadrol (oxymetholone)?
- Anadrol (oxymetholone) has a very high risk profile in the database. Very High (most hepatotoxic of common AAS; HDL crash; severe water retention and BP; paradoxical 'estrogenic' effects — gyno despite no aromatization; headaches common) Legal status: Schedule III US; Rx (anaemia) as Anadrol-50; banned sport.
- What does the low Safety score for Anadrol (oxymetholone) represent?
- The Safety score is 0/10. It records the substantial harms described for one or more use contexts; the Benefit score, indication, dose, route, duration, population, and legal status remain separate parts of the evidence profile.
- What doses or routes are reported for Anadrol (oxymetholone)?
- Clinical: 1-5 mg/kg/day in anemia; illicit 50-150 mg/day PO This is context from studies, approved labeling, clinical practice, or documented use; it is not individualized guidance and does not establish safety.
- How does Anadrol (oxymetholone) work?
- Potent C17-aa DHT derivative; not aromatized but displays estrogenic side effects via unclear mechanism; massive water/glycogen retention; used historically for anemia
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.