AREDS2 formula
Eye · Multi-nutrient combination
Tier A
What this is
The single most evidence-backed eye supplement protocol. AREDS2 (2013) replaced beta-carotene with lutein/zeaxanthin due to lung cancer signal in smokers from original AREDS. Intended for intermediate or advanced AMD — no evidence for prevention in healthy eyes. Ophthalmologist should guide use based on AMD staging.
Mechanism
Vitamin C 500 mg, vitamin E 400 IU, zinc 80 mg (or 25 mg), copper 2 mg, lutein 10 mg, zeaxanthin 2 mg — the modified formula after AREDS2 showed beta-carotene increased lung cancer in smokers
Dose & route
1 tablet 2x/day with food
Citations
- https://pubmed.ncbi.nlm.nih.gov/23644932/
- https://pubmed.ncbi.nlm.nih.gov/11594942/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC4122621/
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.