Saffron (Crocus sativus — eye indication)
Eye · Crocin-rich extract
Tier B
What this is
Listed separately from cognitive use due to different indication and dosing. Italian Bisti group has produced a series of positive small trials showing macular function improvement via ERG in early AMD. Expensive supplement — only buy tested products due to adulteration.
Mechanism
Active crocin and safranal; antioxidant, anti-apoptotic; Italian group (Bisti, Falsini) has specifically studied saffron 20-30 mg/day in AMD and Stargardt with functional endpoints
Dose & route
20-30 mg/day standardized saffron extract
Citations
- https://pubmed.ncbi.nlm.nih.gov/20688572/
- https://pubmed.ncbi.nlm.nih.gov/23076991/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC7146455/
Links go to the source. If a link is dead or you want something re-checked, let me know.
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.