Aspirin (low-dose)
Metabolic Health · Irreversible COX-1 inhibitor
Tier B
Bottom line
Read Off Label grades Aspirin (low-dose) as B (6.8/10) based on strong evidence, strong benefit magnitude, and a med-risk safety profile.
USPSTF 2022 updated: aspirin for primary prevention in ages 40-59 with ≥10% 10-yr ASCVD risk is a Grade C (individualized decision); against for ≥60.
Typical use: 75-100 mg/day PO (81 mg standard in US) — OTC.
What this is
USPSTF 2022 updated: aspirin for primary prevention in ages 40-59 with ≥10% 10-yr ASCVD risk is a Grade C (individualized decision); against for ≥60. Still a cornerstone in secondary prevention. The biohacker default of 'take it just in case' is no longer supported in most healthy people.
Mechanism
Irreversible acetylation of platelet COX-1 for lifetime of platelet; prevents thromboxane A2 synthesis → reduced platelet aggregation
Dose & route
75-100 mg/day PO (81 mg standard in US)
Citations
- https://pubmed.ncbi.nlm.nih.gov/36335050/
- https://pubmed.ncbi.nlm.nih.gov/30221597/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC9459364/
- https://pubmed.ncbi.nlm.nih.gov/40904659/
Links go to the source. If a link is dead or you want something re-checked, let me know.
Common questions
- Does Aspirin (low-dose) work?
- Read Off Label rates the evidence for Aspirin (low-dose) as Strong and the benefit magnitude as strong, producing an overall grade of B (6.8/10). USPSTF 2022 updated: aspirin for primary prevention in ages 40-59 with ≥10% 10-yr ASCVD risk is a Grade C (individualized decision); against for ≥60.
- Is Aspirin (low-dose) safe?
- Aspirin (low-dose) has a med risk profile in published human data. Legal status: OTC. This is not medical advice — see the disclaimer.
- What is the typical dose for Aspirin (low-dose)?
- 75-100 mg/day PO (81 mg standard in US)
- How does Aspirin (low-dose) work?
- Irreversible acetylation of platelet COX-1 for lifetime of platelet; prevents thromboxane A2 synthesis → reduced platelet aggregation
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.