Rankings / Cardiovascular & Lipids
Aspirin (low-dose)
CV/Lipid · Irreversible COX-1 inhibitor
Tier B+
What this is
USPSTF 2022 updated: aspirin for primary prevention in ages 40-59 with ≥10% 10-yr ASCVD risk is a Grade C (individualized decision); against for ≥60. Still a cornerstone in secondary prevention. The biohacker default of 'take it just in case' is no longer supported in most healthy people.
Mechanism
Irreversible acetylation of platelet COX-1 for lifetime of platelet; prevents thromboxane A2 synthesis → reduced platelet aggregation
Dose & route
75-100 mg/day PO (81 mg standard in US)
Citations
- https://pubmed.ncbi.nlm.nih.gov/36335050/
- https://pubmed.ncbi.nlm.nih.gov/30221597/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC9459364/
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.