Rankings / Base — Vitamins & Minerals
B vitamins (B-complex)
Base · Vitamin
Tier A-
What this is
Lowers homocysteine reliably, but B-vitamin supplementation in replete populations has not reduced cardiovascular events or mortality in large RCTs. Stroke signal in some meta-analyses.
Mechanism
Cofactors for energy metabolism, methylation (B9/B12), neurotransmitter synthesis (B6), homocysteine metabolism
Dose & route
B-complex daily; methylated forms (methylfolate, methyl-B12) preferred for MTHFR variants
Citations
- https://pubmed.ncbi.nlm.nih.gov/22652362/
- https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0107060
- https://www.neurology.org/doi/10.1212/WNL.0b013e3182a823cc
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.