Berberine

Longevity · AMPK activator

Tier B

mtor-inhibitionampkmicrobiomeanti-inflammatorybiguanideotc

6.4 / 10

Tier B

Ev 6.0 Bn 5.0 Sf 7.0 Ax 10.0

What this is

Often called 'nature's metformin' — comparable glycemic effects in T2D trials. Meta-analyses show modest reduction in LDL, BP, A1C. Poor absorption; dihydroberberine and berberine phytosome improve bioavailability.

Mechanism

Activates AMPK; mild mTOR inhibition; glucose and lipid lowering similar mechanisms to metformin; anti-inflammatory; alters gut microbiome (may be primary mechanism)

Dose & route

500 mg TID with meals (1500 mg/day total)

Citations

https://pubmed.ncbi.nlm.nih.gov/22614827/
https://pmc.ncbi.nlm.nih.gov/articles/PMC4684835/
https://pubmed.ncbi.nlm.nih.gov/25655519/

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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.