Rankings / Sleep & Recovery
Sleep & Recovery
Sleep aids and exercise/tissue-recovery compounds — melatonin, GABAergic agents, peptides, antioxidants, collagen, omega-3 in the recovery framing.
| # | Compound | Ev | Bn | Sf | Grade · Score |
|---|---|---|---|---|---|
| 1 | Suzetrigine (Journavx / VX-548) Selective Nav1.8 sodium channel inhibitor | 8 | 6.5 | 9 | A+ 8.2 |
| 2 | Melatonin Pineal hormone | 8 | 3.5 | 9 | A- 7.7 |
| 3 | Cognitive behavioral therapy for insomnia (CBT-I) Behavioral sleep | 8 | 8 | 7 | A- 7.6 |
| 4 | DORAs (suvorexant / lemborexant / daridorexant) Orexin receptor antagonists | 8 | 8 | 7 | A- 7.6 |
| 5 | Sunlight / circadian light exposure Light | 8 | 8 | 7 | A- 7.6 |
| 6 | HMB (β-hydroxy β-methylbutyrate) Leucine metabolite | 6 | 3.5 | 10 | B+ 7.2 |
| 7 | Boswellia serrata (AKBA) Boswellic acid / 5-LOX inhibitor | 6 | 5 | 9 | B+ 7.1 |
| 8 | Circadian-aligned eating Fasting | 6 | 5 | 9 | B+ 7.1 |
| 9 | Doxepin (low-dose) H1 antagonist (low dose) | 6 | 5 | 9 | B+ 7.1 |
| 10 | HRV-guided training / biofeedback Other | 6 | 5 | 9 | B+ 7.1 |
| 11 | Lysine (L-lysine) Essential amino acid | 6 | 5 | 9 | B+ 7.1 |
| 12 | PEA (palmitoylethanolamide) Endogenous fatty acid amide | 6 | 5 | 9 | B+ 7.1 |
| 13 | Tart cherry (Prunus cerasus) Anthocyanin-rich fruit extract | 6 | 2 | 10 | B+ 7 |
| 14 | Hyaluronic acid (oral + intra-articular) Glycosaminoglycan | 6 | 3.5 | 9 | B 6.8 |
| 15 | Mobility work / flexibility training Movement | 6 | 3.5 | 9 | B 6.8 |
| 16 | PEMF therapy (pulsed electromagnetic field) Other | 6 | 3.5 | 9 | B 6.8 |
| 17 | Glutamine Amino acid | 6 | 2 | 9 | B 6.6 |
| 18 | Contrast therapy (hot/cold) Thermal | 6 | 5 | 7 | B- 6.3 |
| 19 | Trazodone 5-HT2A antagonist / SARI | 6 | 5 | 7 | B- 6.3 |
| 20 | Glucosamine + chondroitin Joint matrix substrate | 4 | 3.5 | 10 | B- 6.3 |
| 21 | Z-drugs (zolpidem / eszopiclone / zaleplon) GABA-A alpha-1 positive modulators | 8 | 8 | 3.5 | B- High-risk profile 6.2 |
| 22 | Glycine Amino acid / NMDA co-agonist | 4.5 | 3.5 | 9 | B- 6.2 |
| 23 | Valerian (Valeriana officinalis) Herbal sedative | 4.5 | 3.5 | 9 | B- 6.2 |
| 24 | Thymosin alpha-1 Immunomodulatory peptide | 3 | 5 | 9 | C+ 5.7 |
| 25 | Cold plunge / cold water immersion Thermal | 6 | 5 | 5 | C+ 5.5 |
| 26 | Curcumin (turmeric) Polyphenol | 6 | 5 | 5 | C+ 5.5 |
| 27 | Hyperbaric oxygen therapy (HBOT) Oxygen/Pressure | 6 | 5 | 5 | C+ 5.5 |
| 28 | Apigenin Flavonoid / GABA-A modulator | 3 | 3.5 | 9 | C+ 5.5 |
| 29 | CBD (cannabidiol) Non-psychoactive cannabinoid | 4.5 | 3.5 | 7 | C+ 5.4 |
| 30 | SPMs (specialized pro-resolving mediators) Lipid signaling molecules | 2 | 3.5 | 9 | C 5 |
| 31 | Pentosan polysulfate (Elmiron) Semisynthetic heparinoid | 4.5 | 5 | 5 | C 4.8 |
| 32 | THC / cannabis products Cannabinoid / THC agonist | 3.5 | 3.5 | 5 | C- 4.1 |
| 33 | High-volume IV hydration / infusion clinics IV infusion protocol | 3 | 3.5 | 5 | D+ 3.9 |
| 34 | KPV (Lys-Pro-Val) Tripeptide (alpha-MSH fragment) | 2 | 5 | 4 | D 3.3 |
| 35 | LL-37 (cathelicidin) Antimicrobial peptide | 2 | 5 | 4 | D 3.3 |
| 36 | Tramadol / prescription opioid analgesics Opioid analgesic / pain masking | 3 | 5 | 2 | D High-risk profile 2.9 |
| 37 | BPC-157 (Body Protection Compound-157) Pentadecapeptide | 2 | 5 | 3 | D High-risk profile 2.9 |
| 38 | TB-500 (Thymosin beta-4 fragment) Synthetic peptide | 2 | 5 | 3 | D High-risk profile 2.9 |
This category covers two overlapping outcomes: falling and staying asleep, and recovering from training and stress. Behavioural sleep interventions have broad evidence, while most sleep-supplement trials report comparatively small effects. The rankings show that difference in evidence depth and effect size.
Behavioural and environmental evidence
For chronic insomnia, both the American Academy of Sleep Medicine and American College of Physicians guidelines identify cognitive behavioural therapy for insomnia (CBT-I) as first-line treatment. Head-to-head trials report more durable effects than sleeping pills without medication-dependence risk. Consistent wake times, morning light, and a cool, dark room also have evidence relevant to sleep timing and continuity.
Supplements: modest but real
Melatonin has its strongest evidence for circadian problems — jet lag, shift work, and delayed sleep phase — where it shifts the body clock. As a general sedative its effect is small: meta-analyses put the reduction in time-to-fall-asleep at roughly 7 minutes. Trials of low, physiologic doses (0.5–1 mg) report similar effects to larger 5–10 mg doses, which produce greater exposure and can increase next-day grogginess. Magnesium evidence is weak-to-moderate and concentrated in older adults and people with low status; glycine, L-theanine, and apigenin remain small or preliminary evidence bases.
Prescription sleep: comparative safety
The dual orexin receptor antagonists (DORAs) — suvorexant, lemborexant, daridorexant — promote sleep by blocking wakefulness signalling and generally carry less next-day impairment and dependence than older Z-drugs. Z-drugs such as zolpidem have efficacy evidence alongside dependence and complex-sleep-behaviour risk, resulting in lower Safety scores. Both classes are prescription-only and studied in clinical treatment contexts.
Recovery
On the recovery side, long-running Finnish cohort studies associate frequent sauna use with lower cardiovascular and all-cause mortality, although confounding remains possible. Cold-water immersion may reduce acute soreness and affect mood, but recovery findings are mixed. Studies also report attenuated hypertrophy adaptation when cold immersion immediately follows resistance training.
Frequently asked
Which sleep interventions have the strongest evidence?
For chronic insomnia, CBT-I has a strong and durable evidence base and is identified as first-line by sleep-medicine guidelines. Consistent schedules, morning light, and a cool, dark room address sleep timing and environment. Supplement effects are generally smaller and more context-dependent.
Does melatonin actually work?
For circadian problems such as jet lag, shift work, and delayed sleep phase, trials report modest effects that depend on timing. As a general sedative, meta-analyses report roughly 7 minutes faster sleep onset. Low-dose studies around 0.5–1 mg report effects similar to those of larger doses.
Are cold plunges good for recovery?
The evidence is mixed. Cold-water immersion can reduce acute soreness and affect mood, while studies of use immediately after resistance training report attenuation of some hypertrophy adaptations. Timing and the outcome being measured therefore change the evidence profile.
Z-drugs or the newer orexin-blocker sleep drugs?
The dual orexin receptor antagonists (daridorexant, lemborexant, suvorexant) generally have lower dependence and next-day-impairment findings than zolpidem-class Z-drugs, producing higher Safety scores. Both are prescription classes studied in clinical treatment contexts.
Scores reflect the published evidence, not a recommendation to use any compound or protocol. Nothing here is medical advice. How we score →