Bupropion (Wellbutrin)
Mental Health · NDRI
Tier B+
What this is
Favored when sexual side effects or weight gain limit SSRI tolerability. Component of Contrave (naltrexone+bupropion) for weight loss. Seizure risk historically cited is mainly with IR formulation or doses >450 mg/day. Often augments stimulants in refractory depression with executive dysfunction.
Mechanism
Norepinephrine-dopamine reuptake inhibitor; weak nicotinic acetylcholine receptor antagonist; unique among antidepressants for lack of sexual dysfunction or sedation; weight-neutral to weight-loss
Dose & route
150-450 mg/day XL; 100-300 mg/day SR divided
Citations
- https://pubmed.ncbi.nlm.nih.gov/14744460/
- https://pubmed.ncbi.nlm.nih.gov/29477251/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC5442424/
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