Citrus bergamot
Metabolic Health · Polyphenol extract
Tier B+
Bottom line
Read Off Label grades Citrus bergamot as B+ (7.1/10) based on moderate evidence, moderate benefit magnitude, and a low-risk safety profile.
Italian research tradition produced most trials.
Typical use: 500-1000 mg/day standardized extract (BPF — Bergamot Polyphenolic Fraction) — OTC.
What this is
Italian research tradition produced most trials. Mollace 2011 and follow-ups consistent for moderate lipid effects. Reasonable adjunct for patients declining statin at low risk or borderline. Quality highly variable — look for standardized BPF with ≥38% polyphenols.
Mechanism
Standardized flavonoid extract (naringin, neohesperidin, melitidin, brutieridin); proposed HMG-CoA reductase modulation and AMPK activation; moderate lipid-lowering
Dose & route
500-1000 mg/day standardized extract (BPF — Bergamot Polyphenolic Fraction)
Citations
- https://pubmed.ncbi.nlm.nih.gov/21600741/
- https://pubmed.ncbi.nlm.nih.gov/31035866/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC6472044/
- https://pubmed.ncbi.nlm.nih.gov/40672421/
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Common questions
- Does Citrus bergamot work?
- Read Off Label rates the evidence for Citrus bergamot as Moderate and the benefit magnitude as moderate, producing an overall grade of B+ (7.1/10). Italian research tradition produced most trials.
- Is Citrus bergamot safe?
- Citrus bergamot has a low risk profile in published human data. Legal status: OTC. This is not medical advice — see the disclaimer.
- What is the typical dose for Citrus bergamot?
- 500-1000 mg/day standardized extract (BPF — Bergamot Polyphenolic Fraction)
- How does Citrus bergamot work?
- Standardized flavonoid extract (naringin, neohesperidin, melitidin, brutieridin); proposed HMG-CoA reductase modulation and AMPK activation; moderate lipid-lowering
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.