CJC-1295 (with/without DAC)
Muscle & Strength · GHRH analog
Tier C-
Bottom line
Read Off Label grades CJC-1295 (with/without DAC) as C- (4.1/10) based on weak evidence, med benefit magnitude, and a med-risk safety profile.
Originating company ConjuChem discontinued clinical development.
Studied, labeled, or reported-use context: CJC-1295 with DAC: 1-2 mg/week subQ; without DAC: 100-300 mcg 1-3x daily — Research peptide; not FDA-approved; banned sport; not individualized guidance.
Frontier potential — editorial judgment, not evidence
This is a separate axis from the grade above. It asks a different question: if this worked in humans, how much would it matter? It is our judgment, it is not part of the composite score, and it cannot raise a grade. A high number here is a statement about the idea, not about whether it works or whether anyone should take it.
What the ceiling rests on
A GHRH analogue that reliably raises endogenous GH and IGF-1 pulses in humans — the pharmacology is real and measurable, not hypothetical, and the DAC version extends half-life enough for infrequent dosing.
Why it may not get there
Raising GH is not the same as benefiting from it. Human data stop at the hormone level; no trial has shown a body-composition, functional, or healthspan outcome in healthy adults. GH excess causes insulin resistance, oedema, carpal tunnel, and is epidemiologically associated with worse rather than better longevity — the long-lived human and animal phenotypes tend to have *lower* GH/IGF-1 signalling.
What would change this A controlled trial with a functional endpoint in healthy adults.
What the evidence says
Originating company ConjuChem discontinued clinical development. Popular in peptide stacks combined with GHRP-6, GHRP-2, or Ipamorelin. 'With DAC' vs 'without DAC' distinction important — DAC flattens physiological GH pulsatility which may be disadvantageous.
Mechanism
Tetra-substituted GHRH(1-29) analog; DAC (drug affinity complex) version binds albumin for multi-day half-life; stimulates pituitary GH release in pulsatile (non-DAC) or tonic (DAC) manner
Studied, labeled, or reported dose & route
CJC-1295 with DAC: 1-2 mg/week subQ; without DAC: 100-300 mcg 1-3x daily
This records doses and routes described in studies, approved labeling, clinical practice, or documented use. It is not individualized guidance and does not establish safety; context changes with indication, formulation, health history, monitoring, and other medicines.
Citations
A link means the source informed this entry; it does not mean every claim on the page comes from that source. If a citation looks wrong or you want a claim re-checked, send a correction.
Common questions
- What does the evidence show about CJC-1295 (with/without DAC)'s effects?
- Read Off Label rates the evidence for CJC-1295 (with/without DAC) as Weak and the benefit magnitude as med, producing an overall grade of C- (4.1/10). Originating company ConjuChem discontinued clinical development.
- What safety findings are reported for CJC-1295 (with/without DAC)?
- CJC-1295 (with/without DAC) has a med risk profile in the database. Med (injection site reactions, flushing, HR increase, headache; DAC form chronically elevates GH rather than preserving physiological pulse) Legal status: Research peptide; not FDA-approved; banned sport.
- What doses or routes are reported for CJC-1295 (with/without DAC)?
- CJC-1295 with DAC: 1-2 mg/week subQ; without DAC: 100-300 mcg 1-3x daily This is context from studies, approved labeling, clinical practice, or documented use; it is not individualized guidance and does not establish safety.
- How does CJC-1295 (with/without DAC) work?
- Tetra-substituted GHRH(1-29) analog; DAC (drug affinity complex) version binds albumin for multi-day half-life; stimulates pituitary GH release in pulsatile (non-DAC) or tonic (DAC) manner
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.