Rankings / Weight Loss — Other
DNP (2,4-dinitrophenol)
Weight loss · Mitochondrial uncoupler
Tier B-
What this is
Do NOT use. Regular deaths reported every year from DNP, often in young bodybuilders. Death can occur from heat stroke within hours. Listed here because it exists in biohacker discussions — included for completeness and warning only.
Mechanism
Dissipates the mitochondrial proton gradient — uncouples oxidative phosphorylation from ATP production; burned calories as heat; extremely potent thermogenic
Dose & route
Illicitly used at 200-600 mg/day — narrow therapeutic window
Citations
- https://pubmed.ncbi.nlm.nih.gov/22005472/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC3550200/
- https://www.fsai.ie/faq/dnp.html
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.