Dulaglutide
Metabolic Health · GLP-1 agonist
Also known as: Trulicity
Tier B
Bottom line
Read Off Label grades Dulaglutide as B (6.4/10) based on strong evidence, med benefit magnitude, and a med-risk safety profile.
Primarily a diabetes drug — weight loss effect less than semaglutide/tirzepatide (~3-5%).
Typical use: Trulicity: 0. — Rx.
What this is
Primarily a diabetes drug — weight loss effect less than semaglutide/tirzepatide (~3-5%). REWIND trial: 12% MACE reduction in broad T2D population. Primary place is T2D management not obesity pharmacotherapy.
Mechanism
Weekly GLP-1 receptor agonist; same mechanism as semaglutide; approved primarily for T2D
Dose & route
Trulicity: 0.75-4.5 mg SC weekly
Citations
- https://www.thelancet.com/journals/lancet/article/PIIS0140-6736(19)31149-3/fulltext
- https://pubmed.ncbi.nlm.nih.gov/31189511/
- https://www.nejm.org/doi/full/10.1056/NEJMoa2107519
- https://pubmed.ncbi.nlm.nih.gov/38892417/
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Common questions
- Does Dulaglutide work?
- Read Off Label rates the evidence for Dulaglutide as Strong and the benefit magnitude as med, producing an overall grade of B (6.4/10). Primarily a diabetes drug — weight loss effect less than semaglutide/tirzepatide (~3-5%).
- Is Dulaglutide safe?
- Dulaglutide has a med risk profile in published human data. Legal status: Rx. This is not medical advice — see the disclaimer.
- What is the typical dose for Dulaglutide?
- Trulicity: 0.75-4.5 mg SC weekly
- How does Dulaglutide work?
- Weekly GLP-1 receptor agonist; same mechanism as semaglutide; approved primarily for T2D
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.