Rankings / Protocols — Fasting
Extended fasting (24-72h+)
Protocols · Fasting
Tier C
What this is
Cheng/Longo work shows hematopoietic stem cell regeneration with 3-day fasts in mice (human data less mature). Risk rises rapidly past 72 hours without supervision. Water-only vs bone broth protocols differ.
Mechanism
Deep ketosis; extensive autophagy; stem cell mobilization (Longo); growth hormone elevation; complete insulin suppression; hematopoietic regeneration signals
Dose & route
24-72h periodic; electrolytes (Na/K/Mg) essential; break gently; quarterly to annually
Citations
- https://www.cell.com/cell-stem-cell/fulltext/S1934-5909(14)00151-9
- https://pubmed.ncbi.nlm.nih.gov/31173147/
- https://www.nature.com/articles/s41467-021-21336-8
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