What does the evidence show about Fasting-mimicking diet (FMD / ProLon)'s effects?

Read Off Label rates the evidence for Fasting-mimicking diet (FMD / ProLon) as Moderate and the benefit magnitude as med, producing an overall grade of B- (6.3/10). Longo/Wei 2017 trial: 3 monthly cycles reduced biological age markers, BMI, blood pressure, IGF-1 in humans.

What safety findings are reported for Fasting-mimicking diet (FMD / ProLon)?

Fasting-mimicking diet (FMD / ProLon) has a low-med risk profile in the database. Low-Med Legal status: Commercial (ProLon) or DIY.

What doses or routes are reported for Fasting-mimicking diet (FMD / ProLon)?

5 days monthly; ~1100 kcal day 1, ~750 kcal days 2-5; very low protein/carb This is context from studies, approved labeling, clinical practice, or documented use; it is not individualized guidance and does not establish safety.

Rankings / Metabolic Health

Fasting-mimicking diet (FMD / ProLon)

Metabolic Health · Fasting

Tier B-

Reviewed by Read Off Label · Last reviewed Jun 8, 2026 · How we grade

autophagyfastingigf-1

6.3 / 10

Tier B-

Ev 6 Bn 5 Sf 7

Bottom line

Read Off Label grades Fasting-mimicking diet (FMD / ProLon) as B- (6.3/10) based on moderate evidence, med benefit magnitude, and a low-med-risk safety profile.

Longo/Wei 2017 trial: 3 monthly cycles reduced biological age markers, BMI, blood pressure, IGF-1 in humans.

Studied, labeled, or reported-use context: 5 days monthly; ~1100 kcal day 1, ~750 kcal days 2-5; very low protein/carb — Commercial (ProLon) or DIY; not individualized guidance.

What the evidence says

Longo/Wei 2017 trial: 3 monthly cycles reduced biological age markers, BMI, blood pressure, IGF-1 in humans. Brandhorst 2024 showed 2.5-year reduction in biological age after 3 cycles.

Mechanism

Low-calorie, low-protein, low-carb 5-day cycles designed to trigger fasting physiology (ketosis, IGF-1 reduction, autophagy) while allowing some food; monthly cycling

Studied, labeled, or reported dose & route

5 days monthly; ~1100 kcal day 1, ~750 kcal days 2-5; very low protein/carb

This records doses and routes described in studies, approved labeling, clinical practice, or documented use. It is not individualized guidance and does not establish safety; context changes with indication, formulation, health history, monitoring, and other medicines.

Citations

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Common questions

What does the evidence show about Fasting-mimicking diet (FMD / ProLon)'s effects?: Read Off Label rates the evidence for Fasting-mimicking diet (FMD / ProLon) as Moderate and the benefit magnitude as med, producing an overall grade of B- (6.3/10). Longo/Wei 2017 trial: 3 monthly cycles reduced biological age markers, BMI, blood pressure, IGF-1 in humans.
What safety findings are reported for Fasting-mimicking diet (FMD / ProLon)?: Fasting-mimicking diet (FMD / ProLon) has a low-med risk profile in the database. Low-Med Legal status: Commercial (ProLon) or DIY.
What doses or routes are reported for Fasting-mimicking diet (FMD / ProLon)?: 5 days monthly; ~1100 kcal day 1, ~750 kcal days 2-5; very low protein/carb This is context from studies, approved labeling, clinical practice, or documented use; it is not individualized guidance and does not establish safety.
How does Fasting-mimicking diet (FMD / ProLon) work?: Low-calorie, low-protein, low-carb 5-day cycles designed to trigger fasting physiology (ketosis, IGF-1 reduction, autophagy) while allowing some food; monthly cycling

This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.