FMT (fecal microbiota transplantation)
Gut · Microbiome transplant
Tier A-
What this is
FDA approved Rebyota (Nov 2022) and Vowst (Apr 2023) as first standardized microbiota products for recurrent CDI. DIY FMT has caused deaths from pathogen transmission. Non-CDI indications remain investigational despite hype. Stool banks closing has limited research FMT access.
Mechanism
Infusion of processed donor stool to restore diversity and specific taxa; lyophilized oral capsules (SER-109/Vowst FDA-approved 2023 for CDI) or traditional colonoscopic/enema delivery; mechanism goes beyond any single strain
Dose & route
Rebyota 150 mL enema once; Vowst 4 capsules daily x3 days
Citations
- https://pubmed.ncbi.nlm.nih.gov/36757260/
- https://www.fda.gov/vaccines-blood-biologics/vaccines/rebyota
- https://pmc.ncbi.nlm.nih.gov/articles/PMC10311226/
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