Rankings / Immune & Inflammation
FMT (fecal microbiota transplantation)
Immune & Inflammation · Microbiome transplant
Tier A-
Bottom line
Read Off Label grades FMT (fecal microbiota transplantation) as A- (7.7/10) based on very strong evidence, strong benefit magnitude, and a med-risk safety profile.
FDA approved Rebyota (Nov 2022) and Vowst (Apr 2023) as first standardized microbiota products for recurrent CDI.
Typical use: Rebyota 150 mL enema once; Vowst 4 capsules daily x3 days — Rx only (OpenBiome closed 2024; now via Rebyota or Vowst); DIY FMT illegal and dangerous.
What this is
FDA approved Rebyota (Nov 2022) and Vowst (Apr 2023) as first standardized microbiota products for recurrent CDI. DIY FMT has caused deaths from pathogen transmission. Non-CDI indications remain investigational despite hype. Stool banks closing has limited research FMT access.
Mechanism
Infusion of processed donor stool to restore diversity and specific taxa; lyophilized oral capsules (SER-109/Vowst FDA-approved 2023 for CDI) or traditional colonoscopic/enema delivery; mechanism goes beyond any single strain
Dose & route
Rebyota 150 mL enema once; Vowst 4 capsules daily x3 days
Citations
- https://pubmed.ncbi.nlm.nih.gov/36757260/
- https://www.fda.gov/vaccines-blood-biologics/vaccines/rebyota
- https://pmc.ncbi.nlm.nih.gov/articles/PMC10311226/
Links go to the source. If a link is dead or you want something re-checked, let me know.
Common questions
- Does FMT (fecal microbiota transplantation) work?
- Read Off Label rates the evidence for FMT (fecal microbiota transplantation) as Very Strong and the benefit magnitude as strong, producing an overall grade of A- (7.7/10). FDA approved Rebyota (Nov 2022) and Vowst (Apr 2023) as first standardized microbiota products for recurrent CDI.
- Is FMT (fecal microbiota transplantation) safe?
- FMT (fecal microbiota transplantation) has a med risk profile in published human data. Legal status: Rx only (OpenBiome closed 2024; now via Rebyota or Vowst); DIY FMT illegal and dangerous. This is not medical advice — see the disclaimer.
- What is the typical dose for FMT (fecal microbiota transplantation)?
- Rebyota 150 mL enema once; Vowst 4 capsules daily x3 days
- How does FMT (fecal microbiota transplantation) work?
- Infusion of processed donor stool to restore diversity and specific taxa; lyophilized oral capsules (SER-109/Vowst FDA-approved 2023 for CDI) or traditional colonoscopic/enema delivery; mechanism goes beyond any single strain
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.