Saccharomyces boulardii
Gut · Probiotic yeast
Tier A-
What this is
Unique advantage of being a yeast — unaffected by concurrent antibiotics. One of the most evidence-backed probiotics for specific GI indications. Goldenberg 2017 Cochrane review supports AAD and CDI prevention. Avoid in immunocompromised or patients with indwelling central venous catheters.
Mechanism
Non-pathogenic yeast (actually a strain of S. cerevisiae); intrinsically antibiotic-resistant (unlike bacterial probiotics); binds C. difficile toxins A and B; secretes 54 kDa protease that neutralizes toxin A
Dose & route
250-500 mg 2x/day during and 2 weeks after antibiotic course
Citations
- https://pubmed.ncbi.nlm.nih.gov/29257353/
- https://pubmed.ncbi.nlm.nih.gov/20171404/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC4006982/
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.