Garlic extract (aged / allicin)
Metabolic Health · Organosulfur polyphenol
Tier B
Bottom line
Read Off Label grades Garlic extract (aged / allicin) as B (6.8/10) based on moderate evidence, low-med benefit magnitude, and a low-risk safety profile.
Ried 2008 and subsequent meta-analyses consistent for modest BP reduction.
Studied, labeled, or reported-use context: 600-1200 mg/day aged garlic extract; 180-600 mg/day allicin-standardized — OTC; not individualized guidance.
What the evidence says
Ried 2008 and subsequent meta-analyses consistent for modest BP reduction. Budoff EBT trials in Kyolic showed slowed coronary calcium progression. Trials generally studied garlic as an adjunct and report modest blood-pressure changes; gastrointestinal effects, odor, and additive bleeding risk remain part of the profile.
Mechanism
Aged garlic extract (AGE, Kyolic) provides S-allyl cysteine; allicin from crushed raw garlic; multiple proposed mechanisms — ACE inhibition, endothelial NO, mild antiplatelet, cholesterol biosynthesis
Studied, labeled, or reported dose & route
600-1200 mg/day aged garlic extract; 180-600 mg/day allicin-standardized
This records doses and routes described in studies, approved labeling, clinical practice, or documented use. It is not individualized guidance and does not establish safety; context changes with indication, formulation, health history, monitoring, and other medicines.
Citations
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Common questions
- What does the evidence show about Garlic extract (aged / allicin)'s effects?
- Read Off Label rates the evidence for Garlic extract (aged / allicin) as Moderate and the benefit magnitude as low-med, producing an overall grade of B (6.8/10). Ried 2008 and subsequent meta-analyses consistent for modest BP reduction.
- What safety findings are reported for Garlic extract (aged / allicin)?
- Garlic extract (aged / allicin) has a low risk profile in the database. Low (garlic breath/body odor; mild GI; bleeding additive with anticoagulants) Legal status: OTC.
- What doses or routes are reported for Garlic extract (aged / allicin)?
- 600-1200 mg/day aged garlic extract; 180-600 mg/day allicin-standardized This is context from studies, approved labeling, clinical practice, or documented use; it is not individualized guidance and does not establish safety.
- How does Garlic extract (aged / allicin) work?
- Aged garlic extract (AGE, Kyolic) provides S-allyl cysteine; allicin from crushed raw garlic; multiple proposed mechanisms — ACE inhibition, endothelial NO, mild antiplatelet, cholesterol biosynthesis
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.