Garlic extract (aged / allicin)
Metabolic Health · Organosulfur polyphenol
Tier B
Bottom line
Read Off Label grades Garlic extract (aged / allicin) as B (6.8/10) based on moderate evidence, low-med benefit magnitude, and a low-risk safety profile.
Ried 2008 and subsequent meta-analyses consistent for modest BP reduction.
Typical use: 600-1200 mg/day aged garlic extract; 180-600 mg/day allicin-standardized — OTC.
What this is
Ried 2008 and subsequent meta-analyses consistent for modest BP reduction. Budoff EBT trials in Kyolic showed slowed coronary calcium progression. Cheap, safe adjunct for patients with mild hypertension who want non-pharma options.
Mechanism
Aged garlic extract (AGE, Kyolic) provides S-allyl cysteine; allicin from crushed raw garlic; multiple proposed mechanisms — ACE inhibition, endothelial NO, mild antiplatelet, cholesterol biosynthesis
Dose & route
600-1200 mg/day aged garlic extract; 180-600 mg/day allicin-standardized
Citations
- https://pubmed.ncbi.nlm.nih.gov/18554422/
- https://pubmed.ncbi.nlm.nih.gov/19138431/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC5651468/
Links go to the source. If a link is dead or you want something re-checked, let me know.
Common questions
- Does Garlic extract (aged / allicin) work?
- Read Off Label rates the evidence for Garlic extract (aged / allicin) as Moderate and the benefit magnitude as low-med, producing an overall grade of B (6.8/10). Ried 2008 and subsequent meta-analyses consistent for modest BP reduction.
- Is Garlic extract (aged / allicin) safe?
- Garlic extract (aged / allicin) has a low risk profile in published human data. Legal status: OTC. This is not medical advice — see the disclaimer.
- What is the typical dose for Garlic extract (aged / allicin)?
- 600-1200 mg/day aged garlic extract; 180-600 mg/day allicin-standardized
- How does Garlic extract (aged / allicin) work?
- Aged garlic extract (AGE, Kyolic) provides S-allyl cysteine; allicin from crushed raw garlic; multiple proposed mechanisms — ACE inhibition, endothelial NO, mild antiplatelet, cholesterol biosynthesis
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.