GHRP-2 / GHRP-6
Muscle & Strength · Ghrelin receptor agonists (earlier generation)
Tier C-
Bottom line
Read Off Label grades GHRP-2 / GHRP-6 as C- (4.1/10) based on weak evidence, med benefit magnitude, and a med-risk safety profile.
Largely superseded by ipamorelin due to cortisol/prolactin rise.
Studied, labeled, or reported-use context: GHRP-2: 100-300 mcg subQ 2-3x/day; GHRP-6: 100-150 mcg subQ 2-3x/day — Research peptide; banned sport; not individualized guidance.
What the evidence says
Largely superseded by ipamorelin due to cortisol/prolactin rise. GHRP-6 famous for voracious hunger — sometimes intentionally used to aid bulking. Development-stage drugs abandoned by Kaken and Wyeth respectively.
Mechanism
Hexapeptides binding GHS-R1a; stimulate pituitary GH release; GHRP-6 notably induces hunger via central ghrelin signaling; GHRP-2 more potent but also raises cortisol and prolactin more than ipamorelin
Studied, labeled, or reported dose & route
GHRP-2: 100-300 mcg subQ 2-3x/day; GHRP-6: 100-150 mcg subQ 2-3x/day
This records doses and routes described in studies, approved labeling, clinical practice, or documented use. It is not individualized guidance and does not establish safety; context changes with indication, formulation, health history, monitoring, and other medicines.
Citations
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Common questions
- What does the evidence show about GHRP-2 / GHRP-6's effects?
- Read Off Label rates the evidence for GHRP-2 / GHRP-6 as Weak and the benefit magnitude as med, producing an overall grade of C- (4.1/10). Largely superseded by ipamorelin due to cortisol/prolactin rise.
- What safety findings are reported for GHRP-2 / GHRP-6?
- GHRP-2 / GHRP-6 has a med risk profile in the database. Med (hunger spikes, water retention, cortisol/prolactin elevation; older/cruder than ipamorelin) Legal status: Research peptide; banned sport.
- What doses or routes are reported for GHRP-2 / GHRP-6?
- GHRP-2: 100-300 mcg subQ 2-3x/day; GHRP-6: 100-150 mcg subQ 2-3x/day This is context from studies, approved labeling, clinical practice, or documented use; it is not individualized guidance and does not establish safety.
- How does GHRP-2 / GHRP-6 work?
- Hexapeptides binding GHS-R1a; stimulate pituitary GH release; GHRP-6 notably induces hunger via central ghrelin signaling; GHRP-2 more potent but also raises cortisol and prolactin more than ipamorelin
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.