GHRP-2 / GHRP-6
Muscle Building · Ghrelin receptor agonists (earlier generation)
Tier C-
What this is
Largely superseded by ipamorelin due to cortisol/prolactin rise. GHRP-6 famous for voracious hunger — sometimes intentionally used to aid bulking. Development-stage drugs abandoned by Kaken and Wyeth respectively.
Mechanism
Hexapeptides binding GHS-R1a; stimulate pituitary GH release; GHRP-6 notably induces hunger via central ghrelin signaling; GHRP-2 more potent but also raises cortisol and prolactin more than ipamorelin
Dose & route
GHRP-2: 100-300 mcg subQ 2-3x/day; GHRP-6: 100-150 mcg subQ 2-3x/day
Citations
- https://pubmed.ncbi.nlm.nih.gov/8895233/
- https://pubmed.ncbi.nlm.nih.gov/12477932/
- https://pubmed.ncbi.nlm.nih.gov/17666911/
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