HIF stabilizers / prolyl-hydroxylase inhibitors (roxadustat / daprodustat / vadadustat)
Muscle & Strength · HIF activating agent
Tier C
What this is
WADA coverage: cobalt, daprodustat/GSK1278863, IOX2, molidustat/BAY 85-3934, roxadustat/FG-4592, vadadustat/AKB-6548, xenon and K-11706. Cobalt and xenon are included here because WADA classifies them as HIF-activating oxygen-delivery agents.
Mechanism
HIF-prolyl hydroxylase inhibition raises endogenous erythropoietin signaling and iron-mobilization pathways, making anemia drugs attractive but risky endurance-doping candidates.
Dose & route
Clinical anemia dosing varies by agent and kidney-disease context; no performance dose
Citations
- https://www.ncbi.nlm.nih.gov/books/NBK305894/
- https://www.wada-ama.org/en/resources/2026-prohibited-list
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.