Ipamorelin
Muscle Building · Selective ghrelin receptor agonist
Tier C-
What this is
The 'cleanest' of the GHRPs — minimal effect on cortisol and prolactin. Classic stack: CJC-1295 (no DAC) + Ipamorelin to produce a synchronized GH pulse. Ph2 studies for postoperative ileus in Helsinn development program; no approval.
Mechanism
Selective GHS-R1a agonist; releases GH from pituitary with minimal impact on cortisol, prolactin, ACTH (unlike GHRP-2/6); short plasma half-life (~2 hr)
Dose & route
200-300 mcg subQ 2-3x/day (commonly stacked with CJC-1295)
Citations
- https://pubmed.ncbi.nlm.nih.gov/9747020/
- https://pubmed.ncbi.nlm.nih.gov/18443304/
- https://pubmed.ncbi.nlm.nih.gov/24170034/
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.