Rankings / Weight Loss — Incretins & Amylin
Maridebart cafraglutide (MariTide)
Weight loss · GLP-1 agonist + GIP antagonist
Tier B
What this is
Amgen. Phase 2 (Jastreboff NEJM 2025, n=592, NCT05669599): obesity cohort -12.3% to -16.2% body weight at 52 weeks vs -2.5% placebo; T2D cohort -8.4% to -12.3% with HbA1c -1.2 to -1.6 percentage points. Once-monthly dosing is the differentiator vs weekly GLP-1s. Counterintuitive that BOTH GIP agonism (tirzepatide) AND antagonism (MariTide) produce additive weight loss with GLP-1 — pharmacology not fully resolved.
Mechanism
Long-acting peptide-antibody conjugate combining GLP-1 receptor agonism with GIP receptor antagonism (the inverse of tirzepatide's GIP agonism); enables once-monthly dosing
Dose & route
140-420 mg SC every 4-8 weeks; titration schedules vary
Citations
- https://doi.org/10.1056/NEJMoa2504214
- https://doi.org/10.3390/jcm14113812
- https://doi.org/10.1056/NEJMc2514331
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