Does Masteron (drostanolone) work?

Read Off Label rates the evidence for Masteron (drostanolone) as Moderate and the benefit magnitude as med-high, producing an overall grade of C (5.1/10). Originally developed as breast cancer treatment (Masteril).

Is Masteron (drostanolone) safe?

Masteron (drostanolone) has a med-high risk profile in published human data. Legal status: Schedule III US; banned sport. This is not medical advice — see the disclaimer.

Rankings / Muscle & Strength

Masteron (drostanolone)

Muscle & Strength · Injectable DHT-derivative

Tier C

Reviewed by Read Off Label · Last reviewed Jun 8, 2026 · How we grade

bannedcontrolled-substance

5.1 / 10

Tier C

Ev 6 Bn 6.5 Sf 3.5

Bottom line

Read Off Label grades Masteron (drostanolone) as C (5.1/10) based on moderate evidence, med-high benefit magnitude, and a med-high-risk safety profile.

Originally developed as breast cancer treatment (Masteril).

Typical use: Propionate 100 mg EOD or enanthate 200-400 mg/week — Schedule III US; banned sport.

What this is

Originally developed as breast cancer treatment (Masteril). Bodybuilding use focused on pre-contest 'hardening' and anti-estrogenic synergy with other AAS. Strong androgenic effects disproportionate to anabolic — accelerates androgenetic alopecia.

Mechanism

DHT derivative; non-aromatizing; mild anti-estrogen activity (structural similarity to AI exemestane); primarily used for 'hardening' in lean cutting phases

Dose & route

Propionate 100 mg EOD or enanthate 200-400 mg/week

Citations

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Common questions

Does Masteron (drostanolone) work?: Read Off Label rates the evidence for Masteron (drostanolone) as Moderate and the benefit magnitude as med-high, producing an overall grade of C (5.1/10). Originally developed as breast cancer treatment (Masteril).
Is Masteron (drostanolone) safe?: Masteron (drostanolone) has a med-high risk profile in published human data. Legal status: Schedule III US; banned sport. This is not medical advice — see the disclaimer.
What is the typical dose for Masteron (drostanolone)?: Propionate 100 mg EOD or enanthate 200-400 mg/week
How does Masteron (drostanolone) work?: DHT derivative; non-aromatizing; mild anti-estrogen activity (structural similarity to AI exemestane); primarily used for 'hardening' in lean cutting phases

This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.