Rankings / Cardiovascular & Lipids
Nattokinase
CV/Lipid · Fibrinolytic enzyme
Tier C+
What this is
Popularity surged post-COVID in 'microclot' protocols, though mechanism-to-clinical-benefit chain remains speculative there. Some quality products have modest BP-lowering data. Avoid around surgery or with anticoagulants.
Mechanism
Serine protease from Bacillus subtilis natto fermentation; degrades fibrin and may activate plasminogen; anecdotally reduces BP, improves blood rheology
Dose & route
100-200 mg (2000-4000 FU) daily on empty stomach
Citations
- https://pubmed.ncbi.nlm.nih.gov/19060427/
- https://pubmed.ncbi.nlm.nih.gov/28659867/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC5358769/
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.