Pramlintide
Metabolic Health · Amylin analog (short-acting)
Tier B-
Bottom line
Read Off Label grades Pramlintide as B- (6.1/10) based on strong evidence, low-med benefit magnitude, and a med-risk safety profile.
FDA-approved for T1D and T2D as insulin adjunct.
Typical use: Symlin: 60-120 mcg SC before meals — Rx.
What this is
FDA-approved for T1D and T2D as insulin adjunct. Modest weight loss (~1-2 kg) as pure weight-loss agent. Now largely superseded by long-acting cagrilintide and GLP-1s. Requires pre-meal injections.
Mechanism
Synthetic amylin analog; delays gastric emptying; suppresses glucagon and increases satiety; amylin co-secreted with insulin normally
Dose & route
Symlin: 60-120 mcg SC before meals
Citations
- https://pubmed.ncbi.nlm.nih.gov/16373909/
- https://www.ncbi.nlm.nih.gov/books/NBK470294/
- https://pubmed.ncbi.nlm.nih.gov/21775554/
- https://clinicaltrials.gov/study/NCT00392925
Links go to the source. If a link is dead or you want something re-checked, let me know.
Common questions
- Does Pramlintide work?
- Read Off Label rates the evidence for Pramlintide as Strong and the benefit magnitude as low-med, producing an overall grade of B- (6.1/10). FDA-approved for T1D and T2D as insulin adjunct.
- Is Pramlintide safe?
- Pramlintide has a med risk profile in published human data. Legal status: Rx. This is not medical advice — see the disclaimer.
- What is the typical dose for Pramlintide?
- Symlin: 60-120 mcg SC before meals
- How does Pramlintide work?
- Synthetic amylin analog; delays gastric emptying; suppresses glucagon and increases satiety; amylin co-secreted with insulin normally
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.