Pramlintide
Metabolic Health · Amylin analog (short-acting)
Tier B-
Bottom line
Read Off Label grades Pramlintide as B- (6.1/10) based on strong evidence, low-med benefit magnitude, and a med-risk safety profile.
FDA-approved for T1D and T2D as insulin adjunct.
Studied, labeled, or reported-use context: Symlin: 60-120 mcg SC before meals — Rx; not individualized guidance.
Citation correction in progress
1 PubMed link was found to be unrelated to this entry and removed from public output. The remaining sources are shown below, but this row's claims and score still need a full source-by-source revalidation.
What the evidence says
FDA-approved for T1D and T2D as insulin adjunct. Modest weight loss (~1-2 kg) as pure weight-loss agent. Now largely superseded by long-acting cagrilintide and GLP-1s. Requires pre-meal injections.
Mechanism
Synthetic amylin analog; delays gastric emptying; suppresses glucagon and increases satiety; amylin co-secreted with insulin normally
Studied, labeled, or reported dose & route
Symlin: 60-120 mcg SC before meals
This records doses and routes described in studies, approved labeling, clinical practice, or documented use. It is not individualized guidance and does not establish safety; context changes with indication, formulation, health history, monitoring, and other medicines.
Citations
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Common questions
- What does the evidence show about Pramlintide's effects?
- Read Off Label rates the evidence for Pramlintide as Strong and the benefit magnitude as low-med, producing an overall grade of B- (6.1/10). FDA-approved for T1D and T2D as insulin adjunct.
- What safety findings are reported for Pramlintide?
- Pramlintide has a med risk profile in the database. Med (nausea very common; severe hypoglycemia if used with insulin) Legal status: Rx.
- What doses or routes are reported for Pramlintide?
- Symlin: 60-120 mcg SC before meals This is context from studies, approved labeling, clinical practice, or documented use; it is not individualized guidance and does not establish safety.
- How does Pramlintide work?
- Synthetic amylin analog; delays gastric emptying; suppresses glucagon and increases satiety; amylin co-secreted with insulin normally
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.