Rankings / Weight Loss — Incretins & Amylin
Pramlintide
Weight loss · Amylin analog (short-acting)
Tier B-
What this is
FDA-approved for T1D and T2D as insulin adjunct. Modest weight loss (~1-2 kg) as pure weight-loss agent. Now largely superseded by long-acting cagrilintide and GLP-1s. Requires pre-meal injections.
Mechanism
Synthetic amylin analog; delays gastric emptying; suppresses glucagon and increases satiety; amylin co-secreted with insulin normally
Dose & route
Symlin: 60-120 mcg SC before meals
Citations
- https://pubmed.ncbi.nlm.nih.gov/16373909/
- https://www.ncbi.nlm.nih.gov/books/NBK470294/
- https://pubmed.ncbi.nlm.nih.gov/21775554/
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.