RAD-140 (testolone)
Muscle & Strength · SARM
Tier D+
High-risk evidence profile
Bottom line
Read Off Label grades RAD-140 (testolone) as D+ (3.7/10) based on weak evidence, med-high benefit magnitude, and a med-high-risk safety profile.
Its high-risk evidence profile reflects a Safety score of 3.5/10; reported benefits and harms can differ by indication, dose, route, duration, and population.
Regarded by users as the most 'wet' and strongest SARM — closer to traditional AAS effect profile.
Studied, labeled, or reported-use context: Typical illicit: 10-20 mg/day PO — NOT FDA-approved; gray market; banned sport; not individualized guidance.
Frontier potential — editorial judgment, not evidence
This is a separate axis from the grade above. It asks a different question: if this worked in humans, how much would it matter? It is our judgment, it is not part of the composite score, and it cannot raise a grade. A high number here is a statement about the idea, not about whether it works or whether anyone should take it.
What the ceiling rests on
Strong anabolic and neuroprotective signals in animal models and a high anabolic-to-androgenic ratio in preclinical work, which is the property the entire SARM class is premised on.
Why it may not get there
Clinical development was discontinued, and the FDA has issued warnings citing drug-induced liver injury reports associated with RAD-140 products. There is no published human efficacy trial. A compound whose sponsor stopped developing it and whose regulator has issued a safety communication has a materially lower ceiling than one merely awaiting data.
What would change this None pending — development discontinued.
If you were testing this on yourself
Two properties decide whether an n-of-1 experiment is readable and recoverable. These describe the experiment — they are not a judgment about whether to run it, and nothing here is a recommendation.
Can you undo it?
Potentially permanent
Endogenous suppression as with other SARMs, plus FDA warnings citing reports of drug-induced liver injury — which is not reliably reversible and is not detectable by feel before it is advanced.
Can you tell if it worked?
Readable — Weeks
Lean mass and lifts; liver enzymes and a hormone panel on a blood test.
What would fool you Development was discontinued, so there is no human efficacy trial to compare an individual result against. As with all SARMs sold online, what is in the bottle is unverified.
What the evidence says
Regarded by users as the most 'wet' and strongest SARM — closer to traditional AAS effect profile. Multiple published case reports of drug-induced liver injury. Radius Health halted clinical development. Aggressive marketing as 'legal steroid' despite clear illicit status.
Mechanism
Strong non-steroidal SARM; high anabolic activity in muscle with reduced prostate effects in preclinical; originally developed by Radius Health for breast cancer and now abandoned
Studied, labeled, or reported dose & route
Typical illicit: 10-20 mg/day PO
This records doses and routes described in studies, approved labeling, clinical practice, or documented use. It is not individualized guidance and does not establish safety; context changes with indication, formulation, health history, monitoring, and other medicines.
Citations
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Common questions
- What does the evidence show about RAD-140 (testolone)'s effects?
- Read Off Label rates the evidence for RAD-140 (testolone) as Weak and the benefit magnitude as med-high, producing an overall grade of D+ (3.7/10). Regarded by users as the most 'wet' and strongest SARM — closer to traditional AAS effect profile.
- What safety findings are reported for RAD-140 (testolone)?
- RAD-140 (testolone) has a med-high risk profile in the database. Med-High (notable HPG suppression; hepatotoxicity case reports; aggression reports; potential neurotoxicity in animal models at high doses) Legal status: NOT FDA-approved; gray market; banned sport (WADA).
- What does the low Safety score for RAD-140 (testolone) represent?
- The Safety score is 3.5/10. It records the substantial harms described for one or more use contexts; the Benefit score, indication, dose, route, duration, population, and legal status remain separate parts of the evidence profile.
- What doses or routes are reported for RAD-140 (testolone)?
- Typical illicit: 10-20 mg/day PO This is context from studies, approved labeling, clinical practice, or documented use; it is not individualized guidance and does not establish safety.
- How does RAD-140 (testolone) work?
- Strong non-steroidal SARM; high anabolic activity in muscle with reduced prostate effects in preclinical; originally developed by Radius Health for breast cancer and now abandoned
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.