Sermorelin
Muscle Building · GHRH(1-29) analog
Tier B-
What this is
Considered the most 'physiological' GH-axis intervention because it preserves the pituitary's own regulatory feedback. Geref withdrawn 2008 despite efficacy — commercial decision. Currently only available from compounding pharmacies in US; FDA has restricted some peptide compounding since 2023.
Mechanism
N-terminal 29-amino-acid fragment of endogenous GHRH; natural receptor agonist; very short half-life (~10 min); preserves physiological GH pulsatility and feedback
Dose & route
Typical anti-aging: 200-500 mcg subQ at bedtime
Citations
- https://pubmed.ncbi.nlm.nih.gov/7902352/
- https://pubmed.ncbi.nlm.nih.gov/2646342/
- https://pubmed.ncbi.nlm.nih.gov/24170034/
Links go to the source. If a link is dead or you want something re-checked, let me know.
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.