SLU-PP-332
Metabolic Health · ERR (estrogen-related receptor) agonist / exercise mimetic
Tier D
Bottom line
Read Off Label grades SLU-PP-332 as D (3.3/10) based on preclinical evidence, unknown in humans benefit magnitude, and a unclear-risk safety profile.
The 'exercise in a pill' compound from the Burris lab (Saint Louis University).
Typical use: No established human dose; illicit injectable/oral use circulating — Not approved; research chemical / gray-market peptide-vendor sales; not for human use.
What this is
The 'exercise in a pill' compound from the Burris lab (Saint Louis University). SLU-PP-332 and its successors activate ERR to mimic endurance-exercise adaptations; in mice they raised running capacity ~50%, cut fat mass and improved metabolic syndrome. As of 2026 there are NO human trials — all data is mouse/cell, and improved analogs are still being optimized toward the clinic (Pelagos Pharmaceuticals). Despite that, it is already sold by gray-market peptide vendors and used by biohackers. There is zero human safety or efficacy evidence; this row exists to set that record straight, not to recommend it.
Mechanism
Pan-ERR (alpha/beta/gamma) agonist that switches on the transcriptional program normally triggered by endurance exercise — boosting mitochondrial biogenesis, fat oxidation and aerobic capacity in mice
Dose & route
No established human dose; illicit injectable/oral use circulating
Citations
- https://www.acs.org/pressroom/presspacs/2024/march/mimicking-exercise-with-a-pill.html
- https://pmc.ncbi.nlm.nih.gov/articles/PMC11584170/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC10801787/
Links go to the source. If a link is dead or you want something re-checked, let me know.
Common questions
- Does SLU-PP-332 work?
- Read Off Label rates the evidence for SLU-PP-332 as Preclinical and the benefit magnitude as unknown in humans, producing an overall grade of D (3.3/10). The 'exercise in a pill' compound from the Burris lab (Saint Louis University).
- Is SLU-PP-332 safe?
- SLU-PP-332 has a unclear risk profile in published human data. Legal status: Not approved; research chemical / gray-market peptide-vendor sales; not for human use. This is not medical advice — see the disclaimer.
- What is the typical dose for SLU-PP-332?
- No established human dose; illicit injectable/oral use circulating
- How does SLU-PP-332 work?
- Pan-ERR (alpha/beta/gamma) agonist that switches on the transcriptional program normally triggered by endurance exercise — boosting mitochondrial biogenesis, fat oxidation and aerobic capacity in mice
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.