Tesofensine
Metabolic Health · Triple monoamine reuptake inhibitor
Tier D+
Bottom line
Read Off Label grades Tesofensine as D+ (3.7/10) based on weak evidence, med-high benefit magnitude, and a med-high-risk safety profile.
Saniona now developing for hypothalamic obesity (rare disease orphan indication).
Typical use: 0. — Investigational in multiple jurisdictions; not approved.
What this is
Saniona now developing for hypothalamic obesity (rare disease orphan indication). Substantial weight loss in obesity trials. Cognitive trials disappointed. Research chem availability exists; caution with CV effects.
Mechanism
Inhibits DAT, NET, SERT; originally developed by NeuroSearch for Alzheimer's/Parkinson's (failed primary endpoints); repurposed for obesity with striking weight loss effects
Dose & route
0.25-1 mg/day PO in obesity trials
Citations
- https://pubmed.ncbi.nlm.nih.gov/18206399/
- https://pubmed.ncbi.nlm.nih.gov/18842805/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC9269579/
- https://pubmed.ncbi.nlm.nih.gov/40843857/
- https://doi.org/10.4274/jcrpe.galenos.2025.2025-12-12
- https://pubmed.ncbi.nlm.nih.gov/18950853/
- https://www.sciencedirect.com/science/article/abs/pii/S0140673608615251
- https://en.wikipedia.org/wiki/Tesofensine
Links go to the source. If a link is dead or you want something re-checked, let me know.
Common questions
- Does Tesofensine work?
- Read Off Label rates the evidence for Tesofensine as Weak and the benefit magnitude as med-high, producing an overall grade of D+ (3.7/10). Saniona now developing for hypothalamic obesity (rare disease orphan indication).
- Is Tesofensine safe?
- Tesofensine has a med-high risk profile in published human data. Legal status: Investigational in multiple jurisdictions; not approved. This is not medical advice — see the disclaimer.
- What is the typical dose for Tesofensine?
- 0.25-1 mg/day PO in obesity trials
- How does Tesofensine work?
- Inhibits DAT, NET, SERT; originally developed by NeuroSearch for Alzheimer's/Parkinson's (failed primary endpoints); repurposed for obesity with striking weight loss effects
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.