Rankings / Weight Loss — Other
Tesofensine
Weight loss · Triple monoamine reuptake inhibitor
Tier B-
What this is
TIPO-1: ~10.6% weight loss at 0.5 mg over 24 weeks — roughly double the weight loss of first-gen weight loss drugs like sibutramine/rimonabant. Phase 3 trials ongoing. Cardiovascular safety requires monitoring.
Mechanism
Inhibits presynaptic reuptake of noradrenaline, dopamine, and serotonin; appetite suppression via hypothalamic pathways; also increases resting energy expenditure
Dose & route
0.25-0.5 mg PO daily
Citations
- https://pubmed.ncbi.nlm.nih.gov/18950853/
- https://www.sciencedirect.com/science/article/abs/pii/S0140673608615251
- https://en.wikipedia.org/wiki/Tesofensine
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.