Trenbolone
Muscle & Strength · Injectable 19-nor steroid (~5x androgen activity)
Tier C
High-risk evidence profile
Bottom line
Read Off Label grades Trenbolone as C (5.1/10) based on strong evidence, very high benefit magnitude, and a very high-risk safety profile.
Its high-risk evidence profile reflects a Safety score of 0/10; reported benefits and harms can differ by indication, dose, route, duration, and population.
Not approved for human use anywhere.
Studied, labeled, or reported-use context: Illicit: acetate 50-100 mg EOD; enanthate 200-400 mg/week — Schedule III US (when diverted for human use); banned sport; not individualized guidance.
What the evidence says
Not approved for human use anywhere. Consistently rated by bodybuilders as the harshest AAS for side effects despite strong results. Distinct cardiovascular and renal toxicity beyond what's seen with other AAS. Home-brewed from cattle implants in older illicit markets. Very high Benefit reflects striking anabolic/body-composition effects; very low Safety reflects severe harm potential.
Mechanism
19-nor derivative; ~5x AR binding affinity vs testosterone; does not aromatize; progestogenic; increases IGF-1 locally; veterinary compound (Finaplix cattle pellets)
Studied, labeled, or reported dose & route
Illicit: acetate 50-100 mg EOD; enanthate 200-400 mg/week
This records doses and routes described in studies, approved labeling, clinical practice, or documented use. It is not individualized guidance and does not establish safety; context changes with indication, formulation, health history, monitoring, and other medicines.
Citations
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Common questions
- What does the evidence show about Trenbolone's effects?
- Read Off Label rates the evidence for Trenbolone as Strong and the benefit magnitude as very high, producing an overall grade of C (5.1/10). Not approved for human use anywhere.
- What safety findings are reported for Trenbolone?
- Trenbolone has a very high risk profile in the database. Very High (severe night sweats, insomnia, aggression, anxiety; cardiotoxicity — unique renal toxicity signature; prolactin issues; no aromatization but gyno still possible; 'tren cough') Legal status: Schedule III US (when diverted for human use); banned sport.
- What does the low Safety score for Trenbolone represent?
- The Safety score is 0/10. It records the substantial harms described for one or more use contexts; the Benefit score, indication, dose, route, duration, population, and legal status remain separate parts of the evidence profile.
- What doses or routes are reported for Trenbolone?
- Illicit: acetate 50-100 mg EOD; enanthate 200-400 mg/week This is context from studies, approved labeling, clinical practice, or documented use; it is not individualized guidance and does not establish safety.
- How does Trenbolone work?
- 19-nor derivative; ~5x AR binding affinity vs testosterone; does not aromatize; progestogenic; increases IGF-1 locally; veterinary compound (Finaplix cattle pellets)
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.