Read Off Label rates the evidence for YK-11 as Very Weak and the benefit magnitude as unclear, producing an overall grade of D (2.9/10). Despite frequent 'best SARM' marketing in forums, human data is functionally zero — all evidence from in vitro myoblast studies by Kanno.

YK-11 has a unknown-high risk profile in published human data. Legal status: NOT FDA-approved; gray market; banned sport. This is not medical advice — see the disclaimer.

YK-11

Muscle & Strength · Myostatin inhibitor / SARM-like

Tier D

Reviewed by Read Off Label · Last reviewed Jun 8, 2026 · How we grade

anabolicbannedresearch-only

2.9 / 10

Tier D

Ev 2 Bn 5 Sf 3

Bottom line

Read Off Label grades YK-11 as D (2.9/10) based on very weak evidence, unclear benefit magnitude, and a unknown-high-risk safety profile.

Despite frequent 'best SARM' marketing in forums, human data is functionally zero — all evidence from in vitro myoblast studies by Kanno.

Typical use: Typical illicit: 5-10 mg/day PO — NOT FDA-approved; gray market; banned sport.

What this is

Despite frequent 'best SARM' marketing in forums, human data is functionally zero — all evidence from in vitro myoblast studies by Kanno. Steroidal backbone means it's more an oral AAS than a SARM. Avoid.

Mechanism

Structurally a steroidal SARM derivative (methylated DHT backbone); proposed dual action — partial AR agonism plus inhibition of myostatin via follistatin upregulation; in vitro data only

Dose & route

Typical illicit: 5-10 mg/day PO

Citations

Links go to the source. If a link is dead or you want something re-checked, let me know.

Common questions

Does YK-11 work?: Read Off Label rates the evidence for YK-11 as Very Weak and the benefit magnitude as unclear, producing an overall grade of D (2.9/10). Despite frequent 'best SARM' marketing in forums, human data is functionally zero — all evidence from in vitro myoblast studies by Kanno.
Is YK-11 safe?: YK-11 has a unknown-high risk profile in published human data. Legal status: NOT FDA-approved; gray market; banned sport. This is not medical advice — see the disclaimer.
What is the typical dose for YK-11?: Typical illicit: 5-10 mg/day PO
How does YK-11 work?: Structurally a steroidal SARM derivative (methylated DHT backbone); proposed dual action — partial AR agonism plus inhibition of myostatin via follistatin upregulation; in vitro data only

This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.