Rankings / Mental Health
Mental Health
Antidepressants, anxiolytics, mood stabilisers, and adaptogenic compounds. Narrower than cognitive — focused on the affective axis, prescription and natural.
| # | Compound | Ev | Bn | Sf | Grade · Score |
|---|---|---|---|---|---|
| 1 | TMS (transcranial magnetic stimulation) Non-invasive neuromodulation | 8.0 | 8.0 | 9.0 | A- 7.8 |
| 2 | Bupropion (Wellbutrin) NDRI | 8.0 | 8.0 | 5.0 | B+ 7.1 |
| 3 | Dextromethorphan-bupropion (Auvelity / AXS-05) NMDA antagonist + sigma-1 agonist + NDRI | 8.0 | 8.0 | 5.0 | B+ 7.1 |
| 4 | SNRIs (venlafaxine / duloxetine) Dual SERT/NET reuptake inhibitor | 8.0 | 8.0 | 5.0 | B+ 7.1 |
| 5 | Xanomeline-trospium (KarXT / Cobenfy) M1/M4 muscarinic agonist + peripheral antagonist | 8.0 | 8.0 | 5.0 | B+ 7.1 |
| 6 | Zuranolone (Zurzuvae) GABA-A neurosteroid (positive allosteric modulator) | 8.0 | 8.0 | 5.0 | B+ 7.1 |
| 7 | Inositol (myo-inositol / D-chiro-inositol) Sugar alcohol / second messenger | 6.0 | 5.0 | 9.0 | B 6.9 |
| 8 | SSRIs (sertraline / escitalopram / fluoxetine) Selective serotonin reuptake inhibitor | 8.0 | 6.5 | 5.0 | B 6.7 |
| 9 | St. John's wort (Hypericum perforatum) Natural SSRI-SNRI-like | 8.0 | 5.0 | 5.0 | B 6.7 |
| 10 | Buspirone 5-HT1A partial agonist | 6.0 | 5.0 | 9.0 | B 6.5 |
| 11 | Lithium (microdose vs therapeutic) Mood stabilizer / geroprotector | 10.0 | 5.0 | 2.0 | B 6.4 |
| 12 | Ashwagandha (Withania somnifera) Adaptogen | 6.0 | 5.0 | 7.0 | B 6.4 |
| 13 | Gabapentin / pregabalin alpha-2-delta voltage-gated Ca channel modulator | 8.0 | 5.0 | 5.0 | B- 6.3 |
| 14 | SAM-e (S-adenosylmethionine) Methyl donor | 6.0 | 5.0 | 7.0 | C+ 5.6 |
| 15 | Kava (Piper methysticum) GABA-A modulator / TRPV1 | 6.0 | 5.0 | 5.0 | C+ 5.4 |
| 16 | 5-HTP (5-hydroxytryptophan) Serotonin precursor | 3.0 | 3.5 | 5.0 | C- 4.3 |