Rankings / Cognitive — Nootropics
Alpha-GPC (alpha-glycerophosphocholine)
Cognitive · Choline precursor
Tier B
What this is
Most bioavailable choline source per mg. De Jesus Moreno 2003 in mild-to-moderate AD showed MMSE benefit over 180 days. Bellar 2015 showed acute power output increase pre-exercise. Some observational data link supplemental choline to elevated stroke risk via TMAO — controversial.
Mechanism
Bioavailable choline source crossing BBB efficiently; rapidly cleaved to choline (ACh precursor) and glycerophosphate (membrane phospholipid substrate)
Dose & route
300-1200 mg/day PO divided
Citations
- https://pubmed.ncbi.nlm.nih.gov/12637119/
- https://pubmed.ncbi.nlm.nih.gov/26179488/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC10098768/
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This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.