Alpha-GPC (alpha-glycerophosphocholine)
Cognitive · Choline precursor
Tier B+
Bottom line
Read Off Label grades Alpha-GPC (alpha-glycerophosphocholine) as B+ (7.1/10) based on moderate evidence, med benefit magnitude, and a low-risk safety profile.
Most bioavailable choline source per mg.
Typical use: 300-1200 mg/day PO divided — OTC (US); Rx in some EU countries.
What this is
Most bioavailable choline source per mg. De Jesus Moreno 2003 in mild-to-moderate AD showed MMSE benefit over 180 days. Bellar 2015 showed acute power output increase pre-exercise. Some observational data link supplemental choline to elevated stroke risk via TMAO — controversial.
Mechanism
Bioavailable choline source crossing BBB efficiently; rapidly cleaved to choline (ACh precursor) and glycerophosphate (membrane phospholipid substrate)
Dose & route
300-1200 mg/day PO divided
Citations
- https://pubmed.ncbi.nlm.nih.gov/12637119/
- https://pubmed.ncbi.nlm.nih.gov/26179488/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC10098768/
Links go to the source. If a link is dead or you want something re-checked, let me know.
Common questions
- Does Alpha-GPC (alpha-glycerophosphocholine) work?
- Read Off Label rates the evidence for Alpha-GPC (alpha-glycerophosphocholine) as Moderate and the benefit magnitude as med, producing an overall grade of B+ (7.1/10). Most bioavailable choline source per mg.
- Is Alpha-GPC (alpha-glycerophosphocholine) safe?
- Alpha-GPC (alpha-glycerophosphocholine) has a low risk profile in published human data. Legal status: OTC (US); Rx in some EU countries. This is not medical advice — see the disclaimer.
- What is the typical dose for Alpha-GPC (alpha-glycerophosphocholine)?
- 300-1200 mg/day PO divided
- How does Alpha-GPC (alpha-glycerophosphocholine) work?
- Bioavailable choline source crossing BBB efficiently; rapidly cleaved to choline (ACh precursor) and glycerophosphate (membrane phospholipid substrate)
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.