Armodafinil
Cognitive · Wakefulness-promoting
Also known as: Nuvigil
Tier B+
Bottom line
Read Off Label grades Armodafinil as B+ (7.4/10) based on strong evidence, med-high benefit magnitude, and a low-med-risk safety profile.
Approved 2007.
Typical use: 150-250 mg PO once daily morning — Rx.
What this is
Approved 2007. Often preferred over modafinil for steadier afternoon wakefulness. Generics available. Same serious-rash and psychiatric warnings as modafinil.
Mechanism
R-enantiomer of modafinil; same mechanism but longer plasma half-life and more sustained PM plasma levels; marketed as Nuvigil
Dose & route
150-250 mg PO once daily morning
Citations
- https://pubmed.ncbi.nlm.nih.gov/20085382/
- https://pubmed.ncbi.nlm.nih.gov/19954264/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC3183109/
- https://doi.org/10.1093/sleep/zsag091.0702
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Common questions
- Does Armodafinil work?
- Read Off Label rates the evidence for Armodafinil as Strong and the benefit magnitude as med-high, producing an overall grade of B+ (7.4/10). Approved 2007.
- Is Armodafinil safe?
- Armodafinil has a low-med risk profile in published human data. Legal status: Rx (Schedule IV US). This is not medical advice — see the disclaimer.
- What is the typical dose for Armodafinil?
- 150-250 mg PO once daily morning
- How does Armodafinil work?
- R-enantiomer of modafinil; same mechanism but longer plasma half-life and more sustained PM plasma levels; marketed as Nuvigil
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.