Armodafinil
Cognitive · Wakefulness-promoting
Also known as: Nuvigil
Tier B+
Bottom line
Read Off Label grades Armodafinil as B+ (7.4/10) based on strong evidence, med-high benefit magnitude, and a low-med-risk safety profile.
Approved 2007.
Studied, labeled, or reported-use context: 150-250 mg PO once daily morning — Rx; not individualized guidance.
What the evidence says
Approved 2007. Its longer half-life produces steadier afternoon exposure than modafinil in some patients. Generics available. Same serious-rash and psychiatric warnings as modafinil.
Mechanism
R-enantiomer of modafinil; same mechanism but longer plasma half-life and more sustained PM plasma levels; marketed as Nuvigil
Studied, labeled, or reported dose & route
150-250 mg PO once daily morning
This records doses and routes described in studies, approved labeling, clinical practice, or documented use. It is not individualized guidance and does not establish safety; context changes with indication, formulation, health history, monitoring, and other medicines.
Citations
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Common questions
- What does the evidence show about Armodafinil's effects?
- Read Off Label rates the evidence for Armodafinil as Strong and the benefit magnitude as med-high, producing an overall grade of B+ (7.4/10). Approved 2007.
- What safety findings are reported for Armodafinil?
- Armodafinil has a low-med risk profile in the database. Low-Med (similar profile to modafinil) Legal status: Rx (Schedule IV US).
- What doses or routes are reported for Armodafinil?
- 150-250 mg PO once daily morning This is context from studies, approved labeling, clinical practice, or documented use; it is not individualized guidance and does not establish safety.
- How does Armodafinil work?
- R-enantiomer of modafinil; same mechanism but longer plasma half-life and more sustained PM plasma levels; marketed as Nuvigil
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.