BPC-157 (Body Protection Compound-157)
Recovery · Pentadecapeptide
Tier D+
What this is
The canonical 'biohacker healing peptide.' Extensive Sikiric preclinical work on tendon, ligament, GI healing. Zero published human RCTs. FDA Jan 2025 final guidance ended legal US compounding access (previously a gray-zone). Ongoing litigation (Evexias/Farmakeio) challenging the FDA process. Widely anecdotally reported to accelerate tendon/joint recovery; evidence base remains preclinical.
Mechanism
Synthetic fragment of a gastric 'body protection' protein; proposed pro-angiogenic via VEGFR2 pathway; nitric oxide pathway modulation; reported tendon/ligament/GI healing in rodent models
Dose & route
250-500 mcg subQ 1-2x daily (anecdotal); also oral capsule forms
Citations
- https://pubmed.ncbi.nlm.nih.gov/33799484/
- https://pubmed.ncbi.nlm.nih.gov/30915550/
- https://www.fda.gov/media/174456/download
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