Rankings / Immune & Inflammation
Colostrum (bovine)
Immune & Inflammation · Immunoglobulin-rich milk
Tier B-
Bottom line
Read Off Label grades Colostrum (bovine) as B- (6.2/10) based on weak-moderate evidence, low-med benefit magnitude, and a low-risk safety profile.
First 24-hour colostrum has highest IgG concentration.
Studied, labeled, or reported-use context: 10-20 g/day PO — OTC; not individualized guidance.
What the evidence says
First 24-hour colostrum has highest IgG concentration. Pasteurization reduces activity modestly. Commercial quality varies enormously. Popular in athlete recovery protocols and gut permeability/'leaky gut' interventions with moderate evidence.
Mechanism
First-milk from cows containing IgG, IgA, IgM, lactoferrin, growth factors (IGF-1, TGF-β), and bioactive peptides; oral IgG transfers immune memory locally in gut
Studied, labeled, or reported dose & route
10-20 g/day PO
This records doses and routes described in studies, approved labeling, clinical practice, or documented use. It is not individualized guidance and does not establish safety; context changes with indication, formulation, health history, monitoring, and other medicines.
Citations
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Common questions
- What does the evidence show about Colostrum (bovine)'s effects?
- Read Off Label rates the evidence for Colostrum (bovine) as Weak-Moderate and the benefit magnitude as low-med, producing an overall grade of B- (6.2/10). First 24-hour colostrum has highest IgG concentration.
- What safety findings are reported for Colostrum (bovine)?
- Colostrum (bovine) has a low risk profile in the database. Low (milk protein allergy; theoretical concerns with unpasteurized products) Legal status: OTC.
- What doses or routes are reported for Colostrum (bovine)?
- 10-20 g/day PO This is context from studies, approved labeling, clinical practice, or documented use; it is not individualized guidance and does not establish safety.
- How does Colostrum (bovine) work?
- First-milk from cows containing IgG, IgA, IgM, lactoferrin, growth factors (IGF-1, TGF-β), and bioactive peptides; oral IgG transfers immune memory locally in gut
This is an independent synthesis of published research by a non-clinician. Scores are opinions supported by citations, not prescriptions. See the full disclaimer and methodology for how this score was produced and what it does and doesn't mean.