DGL (deglycyrrhizinated licorice)
Gut · Mucosal protectant
Tier C+
What this is
Chewable form important — the contact time with oral and upper GI mucosa may be relevant. Older European clinical tradition with relatively thin modern data. Consumer confusion common between DGL (safe) and whole licorice root (hyperaldosteronism risk at chronic use).
Mechanism
Licorice root extract with glycyrrhizin removed (glycyrrhizin causes mineralocorticoid effects — hypokalemia, hypertension); remaining flavonoids support gastric mucosa; promotes mucus and bicarbonate secretion
Dose & route
380-760 mg chewed before meals, 3x/day
Citations
- https://pubmed.ncbi.nlm.nih.gov/3311295/
- https://pubmed.ncbi.nlm.nih.gov/23439798/
- https://pmc.ncbi.nlm.nih.gov/articles/PMC7571078/
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